Transcription Factor RBPJL Is Able to Repress Notch Target Gene Expression but Is Non-Responsive to Notch Activation

SIMPLE SUMMARY: The transcription factor RBPJ is an integral part of the Notch signaling cascade. RBPJ can function as a coactivator when Notch signaling is activated but acts as a repressor in the absence of a Notch stimulus. Here, we characterized the function of RBPJL, a pancreas-specific paralog...

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Detalles Bibliográficos
Autores principales: Pan, Leiling, Hoffmeister, Philipp, Turkiewicz, Aleksandra, Huynh, N. N. Duyen, Große-Berkenbusch, Andreas, Knippschild, Uwe, Gebhardt, J. Christof M., Baumann, Bernd, Borggrefe, Tilman, Oswald, Franz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8508133/
https://www.ncbi.nlm.nih.gov/pubmed/34638511
http://dx.doi.org/10.3390/cancers13195027

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