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Recent Advances in the Discovery and Function of Antimicrobial Molecules in Platelets

The conventional function described for platelets is maintaining vascular integrity. Nevertheless, increasing evidence reveals that platelets can additionally play a crucial role in responding against microorganisms. Activated platelets release molecules with antimicrobial activity. This ability was...

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Detalles Bibliográficos
Autores principales: Aquino-Domínguez, Alba S., Romero-Tlalolini, María de los A., Torres-Aguilar, Honorio, Aguilar-Ruiz, Sergio R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8508203/
https://www.ncbi.nlm.nih.gov/pubmed/34638568
http://dx.doi.org/10.3390/ijms221910230
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author Aquino-Domínguez, Alba S.
Romero-Tlalolini, María de los A.
Torres-Aguilar, Honorio
Aguilar-Ruiz, Sergio R.
author_facet Aquino-Domínguez, Alba S.
Romero-Tlalolini, María de los A.
Torres-Aguilar, Honorio
Aguilar-Ruiz, Sergio R.
author_sort Aquino-Domínguez, Alba S.
collection PubMed
description The conventional function described for platelets is maintaining vascular integrity. Nevertheless, increasing evidence reveals that platelets can additionally play a crucial role in responding against microorganisms. Activated platelets release molecules with antimicrobial activity. This ability was first demonstrated in rabbit serum after coagulation and later in rabbit platelets stimulated with thrombin. Currently, multiple discoveries have allowed the identification and characterization of PMPs (platelet microbicidal proteins) and opened the way to identify kinocidins and CHDPs (cationic host defense peptides) in human platelets. These molecules are endowed with microbicidal activity through different mechanisms that broaden the platelet participation in normal and pathologic conditions. Therefore, this review aims to integrate the currently described platelet molecules with antimicrobial properties by summarizing the pathways towards their identification, characterization, and functional evaluation that have promoted new avenues for studying platelets based on kinocidins and CHDPs secretion.
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spelling pubmed-85082032021-10-13 Recent Advances in the Discovery and Function of Antimicrobial Molecules in Platelets Aquino-Domínguez, Alba S. Romero-Tlalolini, María de los A. Torres-Aguilar, Honorio Aguilar-Ruiz, Sergio R. Int J Mol Sci Review The conventional function described for platelets is maintaining vascular integrity. Nevertheless, increasing evidence reveals that platelets can additionally play a crucial role in responding against microorganisms. Activated platelets release molecules with antimicrobial activity. This ability was first demonstrated in rabbit serum after coagulation and later in rabbit platelets stimulated with thrombin. Currently, multiple discoveries have allowed the identification and characterization of PMPs (platelet microbicidal proteins) and opened the way to identify kinocidins and CHDPs (cationic host defense peptides) in human platelets. These molecules are endowed with microbicidal activity through different mechanisms that broaden the platelet participation in normal and pathologic conditions. Therefore, this review aims to integrate the currently described platelet molecules with antimicrobial properties by summarizing the pathways towards their identification, characterization, and functional evaluation that have promoted new avenues for studying platelets based on kinocidins and CHDPs secretion. MDPI 2021-09-23 /pmc/articles/PMC8508203/ /pubmed/34638568 http://dx.doi.org/10.3390/ijms221910230 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Aquino-Domínguez, Alba S.
Romero-Tlalolini, María de los A.
Torres-Aguilar, Honorio
Aguilar-Ruiz, Sergio R.
Recent Advances in the Discovery and Function of Antimicrobial Molecules in Platelets
title Recent Advances in the Discovery and Function of Antimicrobial Molecules in Platelets
title_full Recent Advances in the Discovery and Function of Antimicrobial Molecules in Platelets
title_fullStr Recent Advances in the Discovery and Function of Antimicrobial Molecules in Platelets
title_full_unstemmed Recent Advances in the Discovery and Function of Antimicrobial Molecules in Platelets
title_short Recent Advances in the Discovery and Function of Antimicrobial Molecules in Platelets
title_sort recent advances in the discovery and function of antimicrobial molecules in platelets
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8508203/
https://www.ncbi.nlm.nih.gov/pubmed/34638568
http://dx.doi.org/10.3390/ijms221910230
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