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The Diverse Applications of Pancreatic Ductal Adenocarcinoma Organoids
SIMPLE SUMMARY: Patients diagnosed with pancreatic cancer have very few treatment options. In order to identify new treatment opportunities, and develop new drugs for clinical use, appropriate model systems that take into account the complexities of a tumor are required. In this review, we summarize...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8508245/ https://www.ncbi.nlm.nih.gov/pubmed/34638463 http://dx.doi.org/10.3390/cancers13194979 |
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author | Low, Ronnie Ren Jie Lim, Wei Wen Nguyen, Paul M. Lee, Belinda Christie, Michael Burgess, Antony W. Gibbs, Peter Grimmond, Sean M. Hollande, Frédéric Putoczki, Tracy L. |
author_facet | Low, Ronnie Ren Jie Lim, Wei Wen Nguyen, Paul M. Lee, Belinda Christie, Michael Burgess, Antony W. Gibbs, Peter Grimmond, Sean M. Hollande, Frédéric Putoczki, Tracy L. |
author_sort | Low, Ronnie Ren Jie |
collection | PubMed |
description | SIMPLE SUMMARY: Patients diagnosed with pancreatic cancer have very few treatment options. In order to identify new treatment opportunities, and develop new drugs for clinical use, appropriate model systems that take into account the complexities of a tumor are required. In this review, we summarize the current and emerging opportunities to accurately model pancreatic cancer using organoid technologies. We highlight the need for continued development of these complex model systems in order to inform personalized treatment. ABSTRACT: Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal solid malignancies. While immortalized cancer cell lines and genetically engineered murine models have increased our understanding of PDAC tumorigenesis, they do not recapitulate inter- and intra-patient heterogeneity. PDAC patient derived organoid (PDO) biobanks have overcome this hurdle, and provide an opportunity for the high throughput screening of potential new therapies. This review provides a summary of the PDAC PDO biobanks established to date, and discusses how they have advanced our understanding of PDAC biology. Looking forward, the development of coculturing techniques for specific immune or stromal cell populations will enable a better understanding of the crosstalk that occurs within the tumor microenvironment, and the impact of this crosstalk on treatment response. |
format | Online Article Text |
id | pubmed-8508245 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-85082452021-10-13 The Diverse Applications of Pancreatic Ductal Adenocarcinoma Organoids Low, Ronnie Ren Jie Lim, Wei Wen Nguyen, Paul M. Lee, Belinda Christie, Michael Burgess, Antony W. Gibbs, Peter Grimmond, Sean M. Hollande, Frédéric Putoczki, Tracy L. Cancers (Basel) Review SIMPLE SUMMARY: Patients diagnosed with pancreatic cancer have very few treatment options. In order to identify new treatment opportunities, and develop new drugs for clinical use, appropriate model systems that take into account the complexities of a tumor are required. In this review, we summarize the current and emerging opportunities to accurately model pancreatic cancer using organoid technologies. We highlight the need for continued development of these complex model systems in order to inform personalized treatment. ABSTRACT: Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal solid malignancies. While immortalized cancer cell lines and genetically engineered murine models have increased our understanding of PDAC tumorigenesis, they do not recapitulate inter- and intra-patient heterogeneity. PDAC patient derived organoid (PDO) biobanks have overcome this hurdle, and provide an opportunity for the high throughput screening of potential new therapies. This review provides a summary of the PDAC PDO biobanks established to date, and discusses how they have advanced our understanding of PDAC biology. Looking forward, the development of coculturing techniques for specific immune or stromal cell populations will enable a better understanding of the crosstalk that occurs within the tumor microenvironment, and the impact of this crosstalk on treatment response. MDPI 2021-10-04 /pmc/articles/PMC8508245/ /pubmed/34638463 http://dx.doi.org/10.3390/cancers13194979 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Low, Ronnie Ren Jie Lim, Wei Wen Nguyen, Paul M. Lee, Belinda Christie, Michael Burgess, Antony W. Gibbs, Peter Grimmond, Sean M. Hollande, Frédéric Putoczki, Tracy L. The Diverse Applications of Pancreatic Ductal Adenocarcinoma Organoids |
title | The Diverse Applications of Pancreatic Ductal Adenocarcinoma Organoids |
title_full | The Diverse Applications of Pancreatic Ductal Adenocarcinoma Organoids |
title_fullStr | The Diverse Applications of Pancreatic Ductal Adenocarcinoma Organoids |
title_full_unstemmed | The Diverse Applications of Pancreatic Ductal Adenocarcinoma Organoids |
title_short | The Diverse Applications of Pancreatic Ductal Adenocarcinoma Organoids |
title_sort | diverse applications of pancreatic ductal adenocarcinoma organoids |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8508245/ https://www.ncbi.nlm.nih.gov/pubmed/34638463 http://dx.doi.org/10.3390/cancers13194979 |
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