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Therapeutic Effects of Inhibition of Sphingosine-1-Phosphate Signaling in HIF-2α Inhibitor-Resistant Clear Cell Renal Cell Carcinoma

SIMPLE SUMMARY: Clear cell renal cell carcinoma is a common malignancy that represents 80% of all kidney tumors. Most tumors harbor an inactivation of the VHL gene, leading to the accumulation of HIF-1α and HIF-2α. Promising clinical results of specific HIF-2α inhibitors will soon lead to new treatm...

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Detalles Bibliográficos
Autores principales:	Hoefflin, Rouven, Harlander, Sabine, Abhari, Behnaz A., Peighambari, Asin, Adlesic, Mojca, Seidel, Philipp, Zodel, Kyra, Haug, Stefan, Göcmen, Burulca, Li, Yong, Lahrmann, Bernd, Grabe, Niels, Heide, Danijela, Boerries, Melanie, Köttgen, Anna, Heikenwalder, Mathias, Frew, Ian J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8508537/ https://www.ncbi.nlm.nih.gov/pubmed/34638286 http://dx.doi.org/10.3390/cancers13194801

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