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Association of genetic liability for psychiatric disorders with accelerometer-assessed physical activity in the UK Biobank
Levels of activity are often affected in psychiatric disorders and can be core symptoms of illness. Advances in technology now allow the accurate assessment of activity levels but it remains unclear whether alterations in activity arise from shared risk factors for developing psychiatric disorders,...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8508577/ https://www.ncbi.nlm.nih.gov/pubmed/33770123 http://dx.doi.org/10.1371/journal.pone.0249189 |
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author | Dennison, Charlotte A. Legge, Sophie E. Bracher-Smith, Matthew Menzies, Georgina Escott-Price, Valentina Smith, Daniel J. Doherty, Aiden R. Owen, Michael J. O’Donovan, Michael C. Walters, James T. R. |
author_facet | Dennison, Charlotte A. Legge, Sophie E. Bracher-Smith, Matthew Menzies, Georgina Escott-Price, Valentina Smith, Daniel J. Doherty, Aiden R. Owen, Michael J. O’Donovan, Michael C. Walters, James T. R. |
author_sort | Dennison, Charlotte A. |
collection | PubMed |
description | Levels of activity are often affected in psychiatric disorders and can be core symptoms of illness. Advances in technology now allow the accurate assessment of activity levels but it remains unclear whether alterations in activity arise from shared risk factors for developing psychiatric disorders, such as genetics, or are better explained as consequences of the disorders and their associated factors. We aimed to examine objectively-measured physical activity in individuals with psychiatric disorders, and assess the role of genetic liability for psychiatric disorders on physical activity. Accelerometer data were available on 95,529 UK Biobank participants, including measures of overall mean activity and minutes per day of moderate activity, walking, sedentary activity, and sleep. Linear regressions measured associations between psychiatric diagnosis and activity levels, and polygenic risk scores (PRS) for psychiatric disorders and activity levels. Genetic correlations were calculated between psychiatric disorders and different types of activity. Having a diagnosis of schizophrenia, bipolar disorder, depression, or autism spectrum disorders (ASD) was associated with reduced overall activity compared to unaffected controls. In individuals without a psychiatric disorder, reduced overall activity levels were associated with PRS for schizophrenia, depression, and ASD. ADHD PRS was associated with increased overall activity. Genetic correlations were consistent with PRS findings. Variation in physical activity is an important feature across psychiatric disorders. Whilst levels of activity are associated with genetic liability to psychiatric disorders to a very limited extent, the substantial differences in activity levels in those with psychiatric disorders most likely arise as a consequences of disorder-related factors. |
format | Online Article Text |
id | pubmed-8508577 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-85085772021-10-13 Association of genetic liability for psychiatric disorders with accelerometer-assessed physical activity in the UK Biobank Dennison, Charlotte A. Legge, Sophie E. Bracher-Smith, Matthew Menzies, Georgina Escott-Price, Valentina Smith, Daniel J. Doherty, Aiden R. Owen, Michael J. O’Donovan, Michael C. Walters, James T. R. PLoS One Research Article Levels of activity are often affected in psychiatric disorders and can be core symptoms of illness. Advances in technology now allow the accurate assessment of activity levels but it remains unclear whether alterations in activity arise from shared risk factors for developing psychiatric disorders, such as genetics, or are better explained as consequences of the disorders and their associated factors. We aimed to examine objectively-measured physical activity in individuals with psychiatric disorders, and assess the role of genetic liability for psychiatric disorders on physical activity. Accelerometer data were available on 95,529 UK Biobank participants, including measures of overall mean activity and minutes per day of moderate activity, walking, sedentary activity, and sleep. Linear regressions measured associations between psychiatric diagnosis and activity levels, and polygenic risk scores (PRS) for psychiatric disorders and activity levels. Genetic correlations were calculated between psychiatric disorders and different types of activity. Having a diagnosis of schizophrenia, bipolar disorder, depression, or autism spectrum disorders (ASD) was associated with reduced overall activity compared to unaffected controls. In individuals without a psychiatric disorder, reduced overall activity levels were associated with PRS for schizophrenia, depression, and ASD. ADHD PRS was associated with increased overall activity. Genetic correlations were consistent with PRS findings. Variation in physical activity is an important feature across psychiatric disorders. Whilst levels of activity are associated with genetic liability to psychiatric disorders to a very limited extent, the substantial differences in activity levels in those with psychiatric disorders most likely arise as a consequences of disorder-related factors. Public Library of Science 2021-03-26 /pmc/articles/PMC8508577/ /pubmed/33770123 http://dx.doi.org/10.1371/journal.pone.0249189 Text en © 2021 Dennison et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Dennison, Charlotte A. Legge, Sophie E. Bracher-Smith, Matthew Menzies, Georgina Escott-Price, Valentina Smith, Daniel J. Doherty, Aiden R. Owen, Michael J. O’Donovan, Michael C. Walters, James T. R. Association of genetic liability for psychiatric disorders with accelerometer-assessed physical activity in the UK Biobank |
title | Association of genetic liability for psychiatric disorders with
accelerometer-assessed physical activity in the UK Biobank |
title_full | Association of genetic liability for psychiatric disorders with
accelerometer-assessed physical activity in the UK Biobank |
title_fullStr | Association of genetic liability for psychiatric disorders with
accelerometer-assessed physical activity in the UK Biobank |
title_full_unstemmed | Association of genetic liability for psychiatric disorders with
accelerometer-assessed physical activity in the UK Biobank |
title_short | Association of genetic liability for psychiatric disorders with
accelerometer-assessed physical activity in the UK Biobank |
title_sort | association of genetic liability for psychiatric disorders with
accelerometer-assessed physical activity in the uk biobank |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8508577/ https://www.ncbi.nlm.nih.gov/pubmed/33770123 http://dx.doi.org/10.1371/journal.pone.0249189 |
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