Mouse Liver Compensates Loss of Sgpl1 by Secretion of Sphingolipids into Blood and Bile

Sphingosine 1 phosphate (S1P) lyase (Sgpl1) catalyses the irreversible cleavage of S1P and thereby the last step of sphingolipid degradation. Loss of Sgpl1 in humans and mice leads to accumulation of sphingolipids and multiple organ injuries. Here, we addressed the role of hepatocyte Sgpl1 for regul...

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Detalles Bibliográficos
Autores principales: Spohner, Anna Katharina, Jakobi, Katja, Trautmann, Sandra, Thomas, Dominique, Schumacher, Fabian, Kleuser, Burkhard, Lütjohann, Dieter, El-Hindi, Khadija, Grösch, Sabine, Pfeilschifter, Josef, Saba, Julie D., Meyer zu Heringdorf, Dagmar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8508615/
https://www.ncbi.nlm.nih.gov/pubmed/34638955
http://dx.doi.org/10.3390/ijms221910617

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8508615/
https://www.ncbi.nlm.nih.gov/pubmed/34638955
http://dx.doi.org/10.3390/ijms221910617

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