P2X4 Receptors Mediate Ca(2+) Release from Lysosomes in Response to Stimulation of P2X7 and H(1) Histamine Receptors

The P2X4 purinergic receptor is targeted to endolysosomes, where it mediates an inward current dependent on luminal ATP and pH. Activation of P2X4 receptors was previously shown to trigger lysosome fusion, but the regulation of P2X4 receptors and their role in lysosomal Ca(2+) signaling are poorly u...

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Detalles Bibliográficos
Autores principales: Tan, Sin-Lih, Barri, Muruj, Atakpa-Adaji, Peace, Taylor, Colin W., St. John Smith, Ewan, Murrell-Lagnado, Ruth D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8508626/
https://www.ncbi.nlm.nih.gov/pubmed/34638832
http://dx.doi.org/10.3390/ijms221910492

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