Cargando…

Universal Properties and Specificities of the β(2)-Adrenergic Receptor-G(s) Protein Complex Activation Mechanism Revealed by All-Atom Molecular Dynamics Simulations

G protein-coupled receptors (GPCRs) are transmembrane proteins of high pharmacological relevance. It has been proposed that their activity is linked to structurally distinct, dynamically interconverting functional states and the process of activation relies on an interconnecting network of conformat...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mitra, Argha, Sarkar, Arijit, Borics, Attila
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8508748/ https://www.ncbi.nlm.nih.gov/pubmed/34638767 http://dx.doi.org/10.3390/ijms221910423

Ejemplares similares

All-Atom Molecular Dynamics Simulations Indicated the Involvement of a Conserved Polar Signaling Channel in the Activation Mechanism of the Type I Cannabinoid Receptor
por: Sarkar, Arijit, et al.
Publicado: (2023)

Correlated Motions of Conserved Polar Motifs Lay out a Plausible Mechanism of G Protein-Coupled Receptor Activation
por: Mitra, Argha, et al.
Publicado: (2021)

Predicting Novel Binding Modes of Agonists to β Adrenergic Receptors Using All-Atom Molecular Dynamics Simulations
por: Vanni, Stefano, et al.
Publicado: (2011)

Optodynamic simulation of β-adrenergic receptor signalling
por: Siuda, Edward R., et al.
Publicado: (2015)

Evaluation of all-atom force fields in viral capsid simulations and properties
por: Teo, Ruijie D., et al.
Publicado: (2021)

Design, Synthesis and Functional Analysis of Cyclic Opioid Peptides with Dmt-Tic Pharmacophore
por: Sarkar, Arijit, et al.
Publicado: (2020)

Gi-protein-coupled β (1)-adrenergic receptor: re-understanding the selectivity of β (1)-adrenergic receptor to G protein : Gi-protein-coupled β (1)-adrenergic receptor
por: Chen, Hao, et al.
Publicado: (2022)

KRAS(G12C)–AMG 510 interaction dynamics revealed by all-atom molecular dynamics simulations
por: Pantsar, Tatu
Publicado: (2020)

Investigating allosteric effects on the functional dynamics of β2-adrenergic ternary complexes with enhanced-sampling simulations
por: Saleh, Noureldin, et al.
Publicado: (2017)

All-atom simulation of the HET-s prion replication
por: Terruzzi, Luca, et al.
Publicado: (2020)

Physical properties of the HIV-1 capsid from all-atom molecular dynamics simulations
por: Perilla, Juan R., et al.
Publicado: (2017)

G(s) protein peptidomimetics as allosteric modulators of the β(2)-adrenergic receptor
por: Boyhus, Lotte-Emilie, et al.
Publicado: (2018)

Elastic properties of dynein motor domain obtained from all-atom molecular dynamics simulations
por: Kamiya, Narutoshi, et al.
Publicado: (2016)

Simulations of Biased Agonists in the β(2) Adrenergic Receptor with Accelerated Molecular Dynamics
por: Tikhonova, Irina G., et al.
Publicado: (2013)

All-Atom MD Simulations of the HBV Capsid Complexed with AT130 Reveal Secondary and Tertiary Structural Changes and Mechanisms of Allostery
por: Pérez-Segura, Carolina, et al.
Publicado: (2021)

Crystal Structure of the β(2)Adrenergic Receptor-Gs protein complex
por: Rasmussen, Søren G.F., et al.
Publicado: (2011)

Probing the Effect of Glucose on the Activity and Stability of β-Glucosidase: An All-Atom Molecular Dynamics Simulation Investigation
por: Konar, Sukanya, et al.
Publicado: (2019)

Structural Properties of Human IAPP Dimer in Membrane Environment Studied by All-Atom Molecular Dynamics Simulations
por: Liu, Na, et al.
Publicado: (2017)

Beyond Modeling: All-Atom Olfactory Receptor Model Simulations
por: Lai, Peter C., et al.
Publicado: (2012)

A Review on Brittle Fracture Nanomechanics by All-Atom Simulations
por: Patil, Sandeep P., et al.
Publicado: (2019)

Molecular dynamic simulations reveal suboptimal binding of salbutamol in T164I variant of β2 adrenergic receptor
por: Bandaru, Srinivas, et al.
Publicado: (2017)

DHHC5 Mediates β-Adrenergic Signaling in Cardiomyocytes by Targeting Gα Proteins
por: Chen, Jessica J., et al.
Publicado: (2020)

Universal atom interferometer simulation of elastic scattering processes
por: Fitzek, Florian, et al.
Publicado: (2020)

Structures of β(1)-adrenergic receptor in complex with Gs and ligands of different efficacies
por: Su, Minfei, et al.
Publicado: (2022)

A universe of atoms, an atom in the universe
por: Silverman, Mark P
Publicado: (2002)

Gα(i) is required for carvedilol-induced β(1) adrenergic receptor β-arrestin biased signaling
por: Wang, Jialu, et al.
Publicado: (2017)

β‐Adrenergic signaling in skin cancer
por: Batalla‐Covello, Jennifer, et al.
Publicado: (2022)

Exploring the deactivation mechanism of human β (2) adrenergic receptor by accelerated molecular dynamic simulations
por: Chen, Jianzhong, et al.
Publicado: (2022)

Lipids and Phosphorylation Conjointly Modulate Complex Formation of β(2)-Adrenergic Receptor and β-arrestin2
por: Pluhackova, Kristyna, et al.
Publicado: (2021)

Local membrane charge regulates β(2) adrenergic receptor coupling to G(i3)
por: Strohman, M. J., et al.
Publicado: (2019)

IgG stimulated β2 adrenergic receptor activation is attenuated in patients with ME/CFS
por: Hartwig, Jelka, et al.
Publicado: (2020)

β(1) Adrenergic Receptor Autoantibodies and IgG Subclasses: Current Status and Unsolved Issues
por: Kawai, Akane, et al.
Publicado: (2023)

The in vivo specificity of synaptic Gβ and Gγ subunits to the α(2a) adrenergic receptor at CNS synapses
por: Yim, Yun Young, et al.
Publicado: (2019)

Binding of BRACO19 to a Telomeric G-Quadruplex DNA Probed by All-Atom Molecular Dynamics Simulations with Explicit Solvent
por: Machireddy, Babitha, et al.
Publicado: (2019)

The IgG3 subclass of β1-adrenergic receptor autoantibodies is an endogenous biaser of β1AR signaling
por: Mohan, Maradumane L., et al.
Publicado: (2021)

Metal Complexes of Singly, Doubly and Triply Linked Porphyrins and Corroles: An Insight into the Physicochemical Properties
por: Hazari, Arijit Singha, et al.
Publicado: (2022)

β-adrenergic modulation of oddball responses in humans
por: Strange, Bryan A, et al.
Publicado: (2007)

Internalization Dissociates β(2)-Adrenergic Receptors
por: Lan, Tien-Hung, et al.
Publicado: (2011)

β-Adrenergic Receptor Signaling in Prostate Cancer
por: Braadland, Peder Rustøen, et al.
Publicado: (2015)

β-Adrenergic Receptor and Insulin Resistance in the Heart
por: Mangmool, Supachoke, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_c1cntsq23l9t211h0m3dvdboj1