Selective Extracellular Signal-Regulated Kinase 1/2 (ERK1/2) Inhibition by the SCH772984 Compound Attenuates In Vitro and In Vivo Inflammatory Responses and Prolongs Survival in Murine Sepsis Models

Sepsis is the leading cause of death in intensive care units worldwide. Current treatments of sepsis are largely supportive and clinical trials using specific pharmacotherapy for sepsis have failed to improve outcomes. Here, we used the lipopolysaccharide (LPS)-stimulated mouse RAW264.7 cell line an...

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Detalles Bibliográficos
Autores principales: Kopczynski, Michal, Rumienczyk, Izabela, Kulecka, Maria, Statkiewicz, Małgorzata, Pysniak, Kazimiera, Sandowska-Markiewicz, Zuzanna, Wojcik-Trechcinska, Urszula, Goryca, Krzysztof, Pyziak, Karolina, Majewska, Eliza, Masiejczyk, Magdalena, Wojcik-Jaszczynska, Katarzyna, Rzymski, Tomasz, Bomsztyk, Karol, Ostrowski, Jerzy, Mikula, Michal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8508766/
https://www.ncbi.nlm.nih.gov/pubmed/34638546
http://dx.doi.org/10.3390/ijms221910204

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