Cargando…

Kahweol Induces Apoptosis in Hepatocellular Carcinoma Cells by Inhibiting the Src/mTOR/STAT3 Signaling Pathway

Kahweol, a coffee-specific diterpene, induces apoptosis in human cancer cells, and some targets of kahweol-mediated apoptosis have been identified. However, the specific apoptotic effects and mechanism of action of kahweol in hepatocellular carcinoma (HCC) cells are unknown. This study was performed...

Descripción completa

Detalles Bibliográficos
Autores principales:	Seo, Hye-Young, Lee, So-Hee, Lee, Ji-Ha, Lee, Jae-Ho, Jang, Byoung Kuk, Kim, Mi Kyung
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8508869/ https://www.ncbi.nlm.nih.gov/pubmed/34638852 http://dx.doi.org/10.3390/ijms221910509

Ejemplares similares

Kahweol Ameliorates the Liver Inflammation through the Inhibition of NF-κB and STAT3 Activation in Primary Kupffer Cells and Primary Hepatocytes
por: Seo, Hye-Young, et al.
Publicado: (2018)

Kahweol activates the Nrf2/HO-1 pathway by decreasing Keap1 expression independently of p62 and autophagy pathways
por: Seo, Hye-Young, et al.
Publicado: (2020)

Kahweol decreases hepatic fibrosis by inhibiting the expression of connective tissue growth factor via the transforming growth factor-beta signaling pathway
por: Seo, Hye-Young, et al.
Publicado: (2017)

Src Inhibition Attenuates Liver Fibrosis by Preventing Hepatic Stellate Cell Activation and Decreasing Connective Tissue Growth Factor
por: Seo, Hye-Young, et al.
Publicado: (2020)

Kahweol Exerts Skin Moisturizing Activities by Upregulating STAT1 Activity
por: Chen, Hongxi, et al.
Publicado: (2021)

Decursin and Doxorubicin Are in Synergy for the Induction of Apoptosis via STAT3 and/or mTOR Pathways in Human Multiple Myeloma Cells
por: Jang, Jinsil, et al.
Publicado: (2013)

The Cytotoxicity of Kahweol in HT-29 Human Colorectal Cancer Cells Is Mediated by Apoptosis and Suppression of Heat Shock Protein 70 Expression
por: Choi, Dong Wook, et al.
Publicado: (2015)

Natural diterpenes from coffee, cafestol and kahweol induce apoptosis through regulation of specificity protein 1 expression in human malignant pleural mesothelioma
por: Lee, Kyung-Ae, et al.
Publicado: (2012)

Targeting mTOR and Src restricts hepatocellular carcinoma growth in a novel murine liver cancer model
por: Walker, Sarah, et al.
Publicado: (2019)

Acute Kahweol Treatment Attenuates Traumatic Brain Injury Neuroinflammation and Functional Deficits
por: Lee, Hung-Fu, et al.
Publicado: (2019)

Increased Levels of Phosphorylated ERK Induce CTGF Expression in Autophagy-Deficient Mouse Hepatocytes
por: Seo, Hye-Young, et al.
Publicado: (2022)

Cafestol and Kahweol: A Review on Their Bioactivities and Pharmacological Properties
por: Ren, Yaqi, et al.
Publicado: (2019)

Recent Updates on the Functional Impact of Kahweol and Cafestol on Cancer
por: Eldesouki, Salma, et al.
Publicado: (2022)

Metformin ameliorates scleroderma via inhibiting Th17 cells and reducing mTOR-STAT3 signaling in skin fibroblasts
por: Moon, Jeonghyeon, et al.
Publicado: (2021)

mTOR Inhibition Leads to Src-Mediated EGFR Internalisation and Degradation in Glioma Cells
por: Colella, Barbara, et al.
Publicado: (2020)

Evogliptin Directly Inhibits Inflammatory and Fibrotic Signaling in Isolated Liver Cells
por: Seo, Hye-Young, et al.
Publicado: (2022)

Kahweol, a Diterpenoid Molecule, Inhibits CTGF-Dependent Synthetic Phenotype Switching and Migration in Vascular Smooth Muscle Cells
por: Lee, Jeong Hee, et al.
Publicado: (2021)

Crocin induces autophagic apoptosis in hepatocellular carcinoma by inhibiting Akt/mTOR activity
por: Yao, Chong, et al.
Publicado: (2018)

Correction to: Metformin ameliorates scleroderma via inhibiting Th17 cells and reducing mTOR-STAT3 signaling in skin fibroblasts
por: Moon, Jeonghyeon, et al.
Publicado: (2021)

The Role of Autophagy in Hepatocellular Carcinoma
por: Lee, Yoo Jin, et al.
Publicado: (2015)

Kahweol from Coffee Induces Apoptosis by Upregulating Activating Transcription Factor 3 in Human Colorectal Cancer Cells
por: Park, Gwang Hun, et al.
Publicado: (2017)

Kahweol inhibits lipid accumulation and induces Glucose-uptake through activation of AMP-activated protein kinase (AMPK)
por: Baek, Jung-Hwan, et al.
Publicado: (2017)

Roles of Src family kinase, Ras, and mTOR signaling in intestinal epithelial homeostasis and tumorigenesis
por: Matozaki, Takashi, et al.
Publicado: (2020)

PS114. Effects of Tianeptine on mTOR Signaling in Rat Hippocampal Neurons
por: Seo, Mi Kyoung, et al.
Publicado: (2016)

mTOR direct crosstalk with STAT5 promotes de novo lipid synthesis and induces hepatocellular carcinoma
por: Li, Ting, et al.
Publicado: (2019)

Anti-Angiogenic and Anti-Inflammatory Properties of Kahweol, a Coffee Diterpene
por: Cárdenas, Casimiro, et al.
Publicado: (2011)

Clusterin Attenuates Hepatic Fibrosis by Inhibiting Hepatic Stellate Cell Activation and Downregulating the Smad3 Signaling Pathway
por: Seo, Hye-Young, et al.
Publicado: (2019)

STAT3 and mTOR: co-operating to drive HIF and angiogenesis
por: Dodd, Kayleigh M., et al.
Publicado: (2015)

Pharmacological inhibition of mTOR attenuates replicative cell senescence and improves cellular function via regulating the STAT3-PIM1 axis in human cardiac progenitor cells
por: Park, Ji Hye, et al.
Publicado: (2020)

Lobeglitazone inhibits LPS-induced NLRP3 inflammasome activation and inflammation in the liver
por: Seo, Hye-Young, et al.
Publicado: (2023)

Activation of mTOR Signaling Pathway in Hepatocellular Carcinoma
por: Ferrín, Gustavo, et al.
Publicado: (2020)

Naa20, the catalytic subunit of NatB complex, contributes to hepatocellular carcinoma by regulating the LKB1–AMPK–mTOR axis
por: Jung, Taek-Yeol, et al.
Publicado: (2020)

C-C motif chemokine ligand 2 promotes myogenesis of myoblasts via the AKT-mTOR pathway
por: Kwak, Mi Kyung, et al.
Publicado: (2022)

Correction: Anti-Angiogenic and Anti-Inflammatory Properties of Kahweol, a Coffee Diterpene
por: Cárdenas, Casimiro, et al.
Publicado: (2011)

Chrysin Induces Apoptosis and Autophagy in Human Melanoma Cells via the mTOR/S6K Pathway
por: Lee, Jae-Han, et al.
Publicado: (2022)

Targeting EGFR/PI3K/AKT/mTOR Signaling in Hepatocellular Carcinoma
por: Bang, Jieun, et al.
Publicado: (2023)

Clinical potential of novel therapeutic targets in breast cancer: CDK4/6, Src, JAK/STAT, PARP, HDAC, and PI3K/AKT/mTOR pathways
por: Hosford, Sarah R, et al.
Publicado: (2014)

mTOR inhibition as a novel gene therapeutic strategy for diabetic retinopathy
por: Lee, Steven Hyun Seung, et al.
Publicado: (2022)

Author Correction: Pharmacological inhibition of mTOR attenuates replicative cell senescence and improves cellular function via regulating the STAT3-PIM1 axis in human cardiac progenitor cells
por: Park, Ji Hye, et al.
Publicado: (2023)

Unraveling Connective Tissue Growth Factor as a Therapeutic Target and Assessing Kahweol as a Potential Drug Candidate in Triple-Negative Breast Cancer Treatment
por: Lee, Jeong Hee, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_connrf85fum7kjnhc0kvdr2ka4