Targeting of Telomeric Repeat-Containing RNA G-Quadruplexes: From Screening to Biophysical and Biological Characterization of a New Hit Compound

DNA G-quadruplex (G4) structures, either within gene promoter sequences or at telomeres, have been extensively investigated as potential small-molecule therapeutic targets. However, although G4s forming at the telomeric DNA have been extensively investigated as anticancer targets, few studies focus...

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Detalles Bibliográficos
Autores principales: Marzano, Simona, Pagano, Bruno, Iaccarino, Nunzia, Di Porzio, Anna, De Tito, Stefano, Vertecchi, Eleonora, Salvati, Erica, Randazzo, Antonio, Amato, Jussara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8508872/
https://www.ncbi.nlm.nih.gov/pubmed/34638655
http://dx.doi.org/10.3390/ijms221910315

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8508872/
https://www.ncbi.nlm.nih.gov/pubmed/34638655
http://dx.doi.org/10.3390/ijms221910315

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