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Harnessing Metabolic Reprogramming to Improve Cancer Immunotherapy

Immune escape is one of the hallmarks of cancer. While metabolic reprogramming provides survival advantage to tumor cancer cells, accumulating data also suggest such metabolic rewiring directly affects the activation, differentiation and function of immune cells, particularly in the tumor microenvir...

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Detalles Bibliográficos
Autores principales: Yan, Liang, Tan, Yanlian, Chen, Guo, Fan, Jun, Zhang, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8508898/
https://www.ncbi.nlm.nih.gov/pubmed/34638609
http://dx.doi.org/10.3390/ijms221910268
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author Yan, Liang
Tan, Yanlian
Chen, Guo
Fan, Jun
Zhang, Jun
author_facet Yan, Liang
Tan, Yanlian
Chen, Guo
Fan, Jun
Zhang, Jun
author_sort Yan, Liang
collection PubMed
description Immune escape is one of the hallmarks of cancer. While metabolic reprogramming provides survival advantage to tumor cancer cells, accumulating data also suggest such metabolic rewiring directly affects the activation, differentiation and function of immune cells, particularly in the tumor microenvironment. Understanding how metabolic reprogramming affects both tumor and immune cells, as well as their interplay, is therefore critical to better modulate tumor immune microenvironment in the era of cancer immunotherapy. In this review, we discuss alterations in several essential metabolic pathways in both tumor and key immune cells, provide evidence on their dynamic interaction, and propose innovative strategies to improve cancer immunotherapy via the modulation of metabolic pathways.
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spelling pubmed-85088982021-10-13 Harnessing Metabolic Reprogramming to Improve Cancer Immunotherapy Yan, Liang Tan, Yanlian Chen, Guo Fan, Jun Zhang, Jun Int J Mol Sci Review Immune escape is one of the hallmarks of cancer. While metabolic reprogramming provides survival advantage to tumor cancer cells, accumulating data also suggest such metabolic rewiring directly affects the activation, differentiation and function of immune cells, particularly in the tumor microenvironment. Understanding how metabolic reprogramming affects both tumor and immune cells, as well as their interplay, is therefore critical to better modulate tumor immune microenvironment in the era of cancer immunotherapy. In this review, we discuss alterations in several essential metabolic pathways in both tumor and key immune cells, provide evidence on their dynamic interaction, and propose innovative strategies to improve cancer immunotherapy via the modulation of metabolic pathways. MDPI 2021-09-24 /pmc/articles/PMC8508898/ /pubmed/34638609 http://dx.doi.org/10.3390/ijms221910268 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Yan, Liang
Tan, Yanlian
Chen, Guo
Fan, Jun
Zhang, Jun
Harnessing Metabolic Reprogramming to Improve Cancer Immunotherapy
title Harnessing Metabolic Reprogramming to Improve Cancer Immunotherapy
title_full Harnessing Metabolic Reprogramming to Improve Cancer Immunotherapy
title_fullStr Harnessing Metabolic Reprogramming to Improve Cancer Immunotherapy
title_full_unstemmed Harnessing Metabolic Reprogramming to Improve Cancer Immunotherapy
title_short Harnessing Metabolic Reprogramming to Improve Cancer Immunotherapy
title_sort harnessing metabolic reprogramming to improve cancer immunotherapy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8508898/
https://www.ncbi.nlm.nih.gov/pubmed/34638609
http://dx.doi.org/10.3390/ijms221910268
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