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Harnessing Metabolic Reprogramming to Improve Cancer Immunotherapy
Immune escape is one of the hallmarks of cancer. While metabolic reprogramming provides survival advantage to tumor cancer cells, accumulating data also suggest such metabolic rewiring directly affects the activation, differentiation and function of immune cells, particularly in the tumor microenvir...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8508898/ https://www.ncbi.nlm.nih.gov/pubmed/34638609 http://dx.doi.org/10.3390/ijms221910268 |
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author | Yan, Liang Tan, Yanlian Chen, Guo Fan, Jun Zhang, Jun |
author_facet | Yan, Liang Tan, Yanlian Chen, Guo Fan, Jun Zhang, Jun |
author_sort | Yan, Liang |
collection | PubMed |
description | Immune escape is one of the hallmarks of cancer. While metabolic reprogramming provides survival advantage to tumor cancer cells, accumulating data also suggest such metabolic rewiring directly affects the activation, differentiation and function of immune cells, particularly in the tumor microenvironment. Understanding how metabolic reprogramming affects both tumor and immune cells, as well as their interplay, is therefore critical to better modulate tumor immune microenvironment in the era of cancer immunotherapy. In this review, we discuss alterations in several essential metabolic pathways in both tumor and key immune cells, provide evidence on their dynamic interaction, and propose innovative strategies to improve cancer immunotherapy via the modulation of metabolic pathways. |
format | Online Article Text |
id | pubmed-8508898 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-85088982021-10-13 Harnessing Metabolic Reprogramming to Improve Cancer Immunotherapy Yan, Liang Tan, Yanlian Chen, Guo Fan, Jun Zhang, Jun Int J Mol Sci Review Immune escape is one of the hallmarks of cancer. While metabolic reprogramming provides survival advantage to tumor cancer cells, accumulating data also suggest such metabolic rewiring directly affects the activation, differentiation and function of immune cells, particularly in the tumor microenvironment. Understanding how metabolic reprogramming affects both tumor and immune cells, as well as their interplay, is therefore critical to better modulate tumor immune microenvironment in the era of cancer immunotherapy. In this review, we discuss alterations in several essential metabolic pathways in both tumor and key immune cells, provide evidence on their dynamic interaction, and propose innovative strategies to improve cancer immunotherapy via the modulation of metabolic pathways. MDPI 2021-09-24 /pmc/articles/PMC8508898/ /pubmed/34638609 http://dx.doi.org/10.3390/ijms221910268 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Yan, Liang Tan, Yanlian Chen, Guo Fan, Jun Zhang, Jun Harnessing Metabolic Reprogramming to Improve Cancer Immunotherapy |
title | Harnessing Metabolic Reprogramming to Improve Cancer Immunotherapy |
title_full | Harnessing Metabolic Reprogramming to Improve Cancer Immunotherapy |
title_fullStr | Harnessing Metabolic Reprogramming to Improve Cancer Immunotherapy |
title_full_unstemmed | Harnessing Metabolic Reprogramming to Improve Cancer Immunotherapy |
title_short | Harnessing Metabolic Reprogramming to Improve Cancer Immunotherapy |
title_sort | harnessing metabolic reprogramming to improve cancer immunotherapy |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8508898/ https://www.ncbi.nlm.nih.gov/pubmed/34638609 http://dx.doi.org/10.3390/ijms221910268 |
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