Adenylate Kinase 4—A Key Regulator of Proliferation and Metabolic Shift in Human Pulmonary Arterial Smooth Muscle Cells via Akt and HIF-1α Signaling Pathways

Increased proliferation of pulmonary arterial smooth muscle cells (PASMCs) in response to chronic hypoxia contributes to pulmonary vascular remodeling in pulmonary hypertension (PH). PH shares numerous similarities with cancer, including a metabolic shift towards glycolysis. In lung cancer, adenylat...

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Detalles Bibliográficos
Autores principales: Wujak, Magdalena, Veith, Christine, Wu, Cheng-Yu, Wilke, Tessa, Kanbagli, Zeki Ilker, Novoyatleva, Tatyana, Guenther, Andreas, Seeger, Werner, Grimminger, Friedrich, Sommer, Natascha, Schermuly, Ralph Theo, Weissmann, Norbert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8508902/
https://www.ncbi.nlm.nih.gov/pubmed/34638712
http://dx.doi.org/10.3390/ijms221910371

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8508902/
https://www.ncbi.nlm.nih.gov/pubmed/34638712
http://dx.doi.org/10.3390/ijms221910371

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