Mebendazole Mediates Proteasomal Degradation of GLI Transcription Factors in Acute Myeloid Leukemia

The prognosis of elderly AML patients is still poor due to chemotherapy resistance. The Hedgehog (HH) pathway is important for leukemic transformation because of aberrant activation of GLI transcription factors. MBZ is a well-tolerated anthelmintic that exhibits strong antitumor effects. Herein, we...

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Detalles Bibliográficos
Autores principales: Freisleben, Fabian, Modemann, Franziska, Muschhammer, Jana, Stamm, Hauke, Brauneck, Franziska, Krispien, Alexander, Bokemeyer, Carsten, Kirschner, Karl N., Wellbrock, Jasmin, Fiedler, Walter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8508953/
https://www.ncbi.nlm.nih.gov/pubmed/34639011
http://dx.doi.org/10.3390/ijms221910670

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8508953/
https://www.ncbi.nlm.nih.gov/pubmed/34639011
http://dx.doi.org/10.3390/ijms221910670

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