Cargando…
Donepezil Regulates LPS and Aβ-Stimulated Neuroinflammation through MAPK/NLRP3 Inflammasome/STAT3 Signaling
The acetylcholinesterase inhibitors donepezil and rivastigmine have been used as therapeutic drugs for Alzheimer’s disease (AD), but their effects on LPS- and Aβ-induced neuroinflammatory responses and the underlying molecular pathways have not been studied in detail in vitro and in vivo. In the pre...
Autores principales: | Kim, Jieun, Lee, Hyun-ju, Park, Seon Kyeong, Park, Jin-Hee, Jeong, Ha-Ram, Lee, Soojung, Lee, Heeyong, Seol, Eunyoung, Hoe, Hyang-Sook |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8508964/ https://www.ncbi.nlm.nih.gov/pubmed/34638977 http://dx.doi.org/10.3390/ijms221910637 |
Ejemplares similares
-
Donepezil ameliorates Aβ pathology but not tau pathology in 5xFAD mice
por: Choi, Hee-Jeong, et al.
Publicado: (2022) -
Idebenone Regulates Aβ and LPS-Induced Neurogliosis and Cognitive Function Through Inhibition of NLRP3 Inflammasome/IL-1β Axis Activation
por: Lee, Hyun-ju, et al.
Publicado: (2022) -
Lomerizine inhibits LPS-mediated neuroinflammation and tau hyperphosphorylation by modulating NLRP3, DYRK1A, and GSK3α/β
por: Park, Jin-Hee, et al.
Publicado: (2023) -
Neuroprotective Effects of Savinin on LPS-Induced Neuroinflammation In Vivo via Regulating MAPK/NF-κB Pathway and NLRP3 Inflammasome Activation
por: Tang, Siqi, et al.
Publicado: (2023) -
The Anti-diabetic Drug Gliquidone Modulates Lipopolysaccharide-Mediated Microglial Neuroinflammatory Responses by Inhibiting the NLRP3 Inflammasome
por: Kim, Jieun, et al.
Publicado: (2021)