Cargando…

Roles of Two Small Leucine-Rich Proteoglycans Decorin and Biglycan in Pregnancy and Pregnancy-Associated Diseases

Two small leucine-rich proteoglycans (SLRP), decorin and biglycan, play important roles in structural–functional integrity of the placenta and fetal membranes, and their alterations can result in several pregnancy-associated diseases. In this review, we briefly discuss normal placental structure and...

Descripción completa

Detalles Bibliográficos
Autores principales: Halari, Chidambra D., Zheng, Michael, Lala, Peeyush K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8509074/
https://www.ncbi.nlm.nih.gov/pubmed/34638928
http://dx.doi.org/10.3390/ijms221910584
_version_ 1784582249406005248
author Halari, Chidambra D.
Zheng, Michael
Lala, Peeyush K.
author_facet Halari, Chidambra D.
Zheng, Michael
Lala, Peeyush K.
author_sort Halari, Chidambra D.
collection PubMed
description Two small leucine-rich proteoglycans (SLRP), decorin and biglycan, play important roles in structural–functional integrity of the placenta and fetal membranes, and their alterations can result in several pregnancy-associated diseases. In this review, we briefly discuss normal placental structure and functions, define and classify SLRPs, and then focus on two SLRPs, decorin (DCN) and biglycan (BGN). We discuss the consequences of deletions/mutations of DCN and BGN. We then summarize DCN and BGN expression in the pregnant uterus, myometrium, decidua, placenta, and fetal membranes. Actions of these SLRPs as ligands are then discussed in the context of multiple binding partners in the extracellular matrix and cell surface (receptors), as well as their alterations in pathological pregnancies, such as preeclampsia, fetal growth restriction, and preterm premature rupture of membranes. Lastly, we raise some unanswered questions as food for thought.
format Online
Article
Text
id pubmed-8509074
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-85090742021-10-13 Roles of Two Small Leucine-Rich Proteoglycans Decorin and Biglycan in Pregnancy and Pregnancy-Associated Diseases Halari, Chidambra D. Zheng, Michael Lala, Peeyush K. Int J Mol Sci Review Two small leucine-rich proteoglycans (SLRP), decorin and biglycan, play important roles in structural–functional integrity of the placenta and fetal membranes, and their alterations can result in several pregnancy-associated diseases. In this review, we briefly discuss normal placental structure and functions, define and classify SLRPs, and then focus on two SLRPs, decorin (DCN) and biglycan (BGN). We discuss the consequences of deletions/mutations of DCN and BGN. We then summarize DCN and BGN expression in the pregnant uterus, myometrium, decidua, placenta, and fetal membranes. Actions of these SLRPs as ligands are then discussed in the context of multiple binding partners in the extracellular matrix and cell surface (receptors), as well as their alterations in pathological pregnancies, such as preeclampsia, fetal growth restriction, and preterm premature rupture of membranes. Lastly, we raise some unanswered questions as food for thought. MDPI 2021-09-30 /pmc/articles/PMC8509074/ /pubmed/34638928 http://dx.doi.org/10.3390/ijms221910584 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Halari, Chidambra D.
Zheng, Michael
Lala, Peeyush K.
Roles of Two Small Leucine-Rich Proteoglycans Decorin and Biglycan in Pregnancy and Pregnancy-Associated Diseases
title Roles of Two Small Leucine-Rich Proteoglycans Decorin and Biglycan in Pregnancy and Pregnancy-Associated Diseases
title_full Roles of Two Small Leucine-Rich Proteoglycans Decorin and Biglycan in Pregnancy and Pregnancy-Associated Diseases
title_fullStr Roles of Two Small Leucine-Rich Proteoglycans Decorin and Biglycan in Pregnancy and Pregnancy-Associated Diseases
title_full_unstemmed Roles of Two Small Leucine-Rich Proteoglycans Decorin and Biglycan in Pregnancy and Pregnancy-Associated Diseases
title_short Roles of Two Small Leucine-Rich Proteoglycans Decorin and Biglycan in Pregnancy and Pregnancy-Associated Diseases
title_sort roles of two small leucine-rich proteoglycans decorin and biglycan in pregnancy and pregnancy-associated diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8509074/
https://www.ncbi.nlm.nih.gov/pubmed/34638928
http://dx.doi.org/10.3390/ijms221910584
work_keys_str_mv AT halarichidambrad rolesoftwosmallleucinerichproteoglycansdecorinandbiglycaninpregnancyandpregnancyassociateddiseases
AT zhengmichael rolesoftwosmallleucinerichproteoglycansdecorinandbiglycaninpregnancyandpregnancyassociateddiseases
AT lalapeeyushk rolesoftwosmallleucinerichproteoglycansdecorinandbiglycaninpregnancyandpregnancyassociateddiseases