Year-long COVID-19 infection reveals within-host evolution of SARS-CoV-2 in a patient with B cell depletion

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BACKGROUND: B-cell depleting therapies may lead to protracted disease and prolonged viral shedding in individuals infected with SARS-CoV-2. Viral persistence in the setting of immunosuppression raises concern for viral evolution. METHODS: Amplification of sub-genomic transcripts for the E gene (sgE)...

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Detalles Bibliográficos
Autores principales: Nussenblatt, Veronique, Roder, Allison E, Das, Sanchita, de Wit, Emmie, Youn, Jung-Ho, Banakis, Stephanie, Mushegian, Alexandra, Mederos, Christopher, Wang, Wei, Chung, Matthew, Pérez-Pérez, Lizzette, Palmore, Tara, Brudno, Jennifer N., Kochenderfer, James N., Ghedin, Elodie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8509089/
https://www.ncbi.nlm.nih.gov/pubmed/34642697
http://dx.doi.org/10.1101/2021.10.02.21264267
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