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Electroencephalography as a Non-Invasive Biomarker of Alzheimer’s Disease: A Forgotten Candidate to Substitute CSF Molecules?
Biomarkers for disease diagnosis and prognosis are crucial in clinical practice. They should be objective and quantifiable and respond to specific therapeutic interventions. Optimal biomarkers should reflect the underlying process (pathological or not), be reproducible, widely available, and allow m...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8509134/ https://www.ncbi.nlm.nih.gov/pubmed/34639229 http://dx.doi.org/10.3390/ijms221910889 |
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author | Monllor, Paloma Cervera-Ferri, Ana Lloret, Maria-Angeles Esteve, Daniel Lopez, Begoña Leon, Jose-Luis Lloret, Ana |
author_facet | Monllor, Paloma Cervera-Ferri, Ana Lloret, Maria-Angeles Esteve, Daniel Lopez, Begoña Leon, Jose-Luis Lloret, Ana |
author_sort | Monllor, Paloma |
collection | PubMed |
description | Biomarkers for disease diagnosis and prognosis are crucial in clinical practice. They should be objective and quantifiable and respond to specific therapeutic interventions. Optimal biomarkers should reflect the underlying process (pathological or not), be reproducible, widely available, and allow measurements repeatedly over time. Ideally, biomarkers should also be non-invasive and cost-effective. This review aims to focus on the usefulness and limitations of electroencephalography (EEG) in the search for Alzheimer’s disease (AD) biomarkers. The main aim of this article is to review the evolution of the most used biomarkers in AD and the need for new peripheral and, ideally, non-invasive biomarkers. The characteristics of the EEG as a possible source for biomarkers will be revised, highlighting its advantages compared to the molecular markers available so far. |
format | Online Article Text |
id | pubmed-8509134 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-85091342021-10-13 Electroencephalography as a Non-Invasive Biomarker of Alzheimer’s Disease: A Forgotten Candidate to Substitute CSF Molecules? Monllor, Paloma Cervera-Ferri, Ana Lloret, Maria-Angeles Esteve, Daniel Lopez, Begoña Leon, Jose-Luis Lloret, Ana Int J Mol Sci Review Biomarkers for disease diagnosis and prognosis are crucial in clinical practice. They should be objective and quantifiable and respond to specific therapeutic interventions. Optimal biomarkers should reflect the underlying process (pathological or not), be reproducible, widely available, and allow measurements repeatedly over time. Ideally, biomarkers should also be non-invasive and cost-effective. This review aims to focus on the usefulness and limitations of electroencephalography (EEG) in the search for Alzheimer’s disease (AD) biomarkers. The main aim of this article is to review the evolution of the most used biomarkers in AD and the need for new peripheral and, ideally, non-invasive biomarkers. The characteristics of the EEG as a possible source for biomarkers will be revised, highlighting its advantages compared to the molecular markers available so far. MDPI 2021-10-08 /pmc/articles/PMC8509134/ /pubmed/34639229 http://dx.doi.org/10.3390/ijms221910889 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Monllor, Paloma Cervera-Ferri, Ana Lloret, Maria-Angeles Esteve, Daniel Lopez, Begoña Leon, Jose-Luis Lloret, Ana Electroencephalography as a Non-Invasive Biomarker of Alzheimer’s Disease: A Forgotten Candidate to Substitute CSF Molecules? |
title | Electroencephalography as a Non-Invasive Biomarker of Alzheimer’s Disease: A Forgotten Candidate to Substitute CSF Molecules? |
title_full | Electroencephalography as a Non-Invasive Biomarker of Alzheimer’s Disease: A Forgotten Candidate to Substitute CSF Molecules? |
title_fullStr | Electroencephalography as a Non-Invasive Biomarker of Alzheimer’s Disease: A Forgotten Candidate to Substitute CSF Molecules? |
title_full_unstemmed | Electroencephalography as a Non-Invasive Biomarker of Alzheimer’s Disease: A Forgotten Candidate to Substitute CSF Molecules? |
title_short | Electroencephalography as a Non-Invasive Biomarker of Alzheimer’s Disease: A Forgotten Candidate to Substitute CSF Molecules? |
title_sort | electroencephalography as a non-invasive biomarker of alzheimer’s disease: a forgotten candidate to substitute csf molecules? |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8509134/ https://www.ncbi.nlm.nih.gov/pubmed/34639229 http://dx.doi.org/10.3390/ijms221910889 |
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