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Intra-Anal Imiquimod Cream against Human Papillomavirus Infection in Men Who Have Sex with Men Living with HIV: A Single-Arm, Open-Label Pilot Study
Men who have sex with men (MSM) living with HIV have a high prevalence and incidence of anal high-risk human papillomavirus (hrHPV) and anal cancer. We conducted an open-label, single-arm pilot study to examine the tolerability of imiquimod cream among MSM aged ≥18 years, living with HIV, who tested...
Autores principales: | , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8509144/ https://www.ncbi.nlm.nih.gov/pubmed/34640496 http://dx.doi.org/10.3390/jcm10194477 |
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author | Durukan, Duygu Phillips, Tiffany R. Murray, Gerald L. Ong, Jason J. Grulich, Andrew E. Poynten, I. Mary Jin, Fengyi Bradshaw, Catriona S. Aguirre, Ivette Silvers, Julie Kent, Helen Atchison, Steph Balgovind, Prisha Cornall, Alyssa Chen, Marcus Y. Fairley, Christopher K. Chow, Eric P. F. |
author_facet | Durukan, Duygu Phillips, Tiffany R. Murray, Gerald L. Ong, Jason J. Grulich, Andrew E. Poynten, I. Mary Jin, Fengyi Bradshaw, Catriona S. Aguirre, Ivette Silvers, Julie Kent, Helen Atchison, Steph Balgovind, Prisha Cornall, Alyssa Chen, Marcus Y. Fairley, Christopher K. Chow, Eric P. F. |
author_sort | Durukan, Duygu |
collection | PubMed |
description | Men who have sex with men (MSM) living with HIV have a high prevalence and incidence of anal high-risk human papillomavirus (hrHPV) and anal cancer. We conducted an open-label, single-arm pilot study to examine the tolerability of imiquimod cream among MSM aged ≥18 years, living with HIV, who tested positive for anal hrHPV at Melbourne Sexual Health Centre between April 2018 and June 2020. We instructed men to apply 6.25 mg imiquimod intra-anally and peri-anally 3 doses per week for 16 weeks (period 1) and then one dose per week for a further 48 weeks (period 2). Twenty-seven MSM enrolled in period 1 and 24 (86%) applied at least 50% of doses. All men reported adverse events (AEs), including 39.5% grade 1, 39.5% grade 2, and 21% grade 3 AEs on at least one occasion. Eighteen MSM (67%) temporarily stopped using imiquimod during period 1, most commonly due to local AEs (n = 11) such as irritation and itching. Eighteen MSM continued in period 2 and all applied at least 50% of doses with no treatment-limiting AEs reported. Imiquimod 3 doses per week caused local AEs in most men and was not well tolerated. In contrast, once-a-week application was well tolerated over 48-weeks with no treatment-limiting AEs. |
format | Online Article Text |
id | pubmed-8509144 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-85091442021-10-13 Intra-Anal Imiquimod Cream against Human Papillomavirus Infection in Men Who Have Sex with Men Living with HIV: A Single-Arm, Open-Label Pilot Study Durukan, Duygu Phillips, Tiffany R. Murray, Gerald L. Ong, Jason J. Grulich, Andrew E. Poynten, I. Mary Jin, Fengyi Bradshaw, Catriona S. Aguirre, Ivette Silvers, Julie Kent, Helen Atchison, Steph Balgovind, Prisha Cornall, Alyssa Chen, Marcus Y. Fairley, Christopher K. Chow, Eric P. F. J Clin Med Article Men who have sex with men (MSM) living with HIV have a high prevalence and incidence of anal high-risk human papillomavirus (hrHPV) and anal cancer. We conducted an open-label, single-arm pilot study to examine the tolerability of imiquimod cream among MSM aged ≥18 years, living with HIV, who tested positive for anal hrHPV at Melbourne Sexual Health Centre between April 2018 and June 2020. We instructed men to apply 6.25 mg imiquimod intra-anally and peri-anally 3 doses per week for 16 weeks (period 1) and then one dose per week for a further 48 weeks (period 2). Twenty-seven MSM enrolled in period 1 and 24 (86%) applied at least 50% of doses. All men reported adverse events (AEs), including 39.5% grade 1, 39.5% grade 2, and 21% grade 3 AEs on at least one occasion. Eighteen MSM (67%) temporarily stopped using imiquimod during period 1, most commonly due to local AEs (n = 11) such as irritation and itching. Eighteen MSM continued in period 2 and all applied at least 50% of doses with no treatment-limiting AEs reported. Imiquimod 3 doses per week caused local AEs in most men and was not well tolerated. In contrast, once-a-week application was well tolerated over 48-weeks with no treatment-limiting AEs. MDPI 2021-09-28 /pmc/articles/PMC8509144/ /pubmed/34640496 http://dx.doi.org/10.3390/jcm10194477 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Durukan, Duygu Phillips, Tiffany R. Murray, Gerald L. Ong, Jason J. Grulich, Andrew E. Poynten, I. Mary Jin, Fengyi Bradshaw, Catriona S. Aguirre, Ivette Silvers, Julie Kent, Helen Atchison, Steph Balgovind, Prisha Cornall, Alyssa Chen, Marcus Y. Fairley, Christopher K. Chow, Eric P. F. Intra-Anal Imiquimod Cream against Human Papillomavirus Infection in Men Who Have Sex with Men Living with HIV: A Single-Arm, Open-Label Pilot Study |
title | Intra-Anal Imiquimod Cream against Human Papillomavirus Infection in Men Who Have Sex with Men Living with HIV: A Single-Arm, Open-Label Pilot Study |
title_full | Intra-Anal Imiquimod Cream against Human Papillomavirus Infection in Men Who Have Sex with Men Living with HIV: A Single-Arm, Open-Label Pilot Study |
title_fullStr | Intra-Anal Imiquimod Cream against Human Papillomavirus Infection in Men Who Have Sex with Men Living with HIV: A Single-Arm, Open-Label Pilot Study |
title_full_unstemmed | Intra-Anal Imiquimod Cream against Human Papillomavirus Infection in Men Who Have Sex with Men Living with HIV: A Single-Arm, Open-Label Pilot Study |
title_short | Intra-Anal Imiquimod Cream against Human Papillomavirus Infection in Men Who Have Sex with Men Living with HIV: A Single-Arm, Open-Label Pilot Study |
title_sort | intra-anal imiquimod cream against human papillomavirus infection in men who have sex with men living with hiv: a single-arm, open-label pilot study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8509144/ https://www.ncbi.nlm.nih.gov/pubmed/34640496 http://dx.doi.org/10.3390/jcm10194477 |
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