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Prognosis Impact of Diabetes in Elderly Women and Men with Non-ST Elevation Acute Coronary Syndrome
Few studies have addressed to date the interaction between sex and diabetes mellitus (DM) in the prognosis of elderly patients with non-ST-segment elevation acute coronary syndrome (NSTEACS). Our aim was to address the role of DM in the prognosis of non-selected elderly patients with NSTEACS accordi...
Autores principales: | , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8509190/ https://www.ncbi.nlm.nih.gov/pubmed/34640420 http://dx.doi.org/10.3390/jcm10194403 |
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author | Díez-Villanueva, Pablo García-Acuña, Jose María Raposeiras-Roubin, Sergio Barrabés, Jose A. Cordero, Alberto Martínez-Sellés, Manuel Bardají, Alfredo Marín, Francisco Ruiz-Nodar, Juan M. Vicente-Ibarra, Nuria Alonso Salinas, Gonzalo L. Cid-Alvárez, Belén Abu Assi, Emad Formiga, Frances Núñez, Julio Núñez, Eduardo Ariza-Solé, Albert Sanchis, Juan |
author_facet | Díez-Villanueva, Pablo García-Acuña, Jose María Raposeiras-Roubin, Sergio Barrabés, Jose A. Cordero, Alberto Martínez-Sellés, Manuel Bardají, Alfredo Marín, Francisco Ruiz-Nodar, Juan M. Vicente-Ibarra, Nuria Alonso Salinas, Gonzalo L. Cid-Alvárez, Belén Abu Assi, Emad Formiga, Frances Núñez, Julio Núñez, Eduardo Ariza-Solé, Albert Sanchis, Juan |
author_sort | Díez-Villanueva, Pablo |
collection | PubMed |
description | Few studies have addressed to date the interaction between sex and diabetes mellitus (DM) in the prognosis of elderly patients with non-ST-segment elevation acute coronary syndrome (NSTEACS). Our aim was to address the role of DM in the prognosis of non-selected elderly patients with NSTEACS according to sex. A retrospective analysis from 11 Spanish NSTEACS registries was conducted, including patients aged ≥70 years. The primary end point was one-year all-cause mortality. A total of 7211 patients were included, 2,770 (38.4%) were women, and 39.9% had DM. Compared with the men, the women were older (79.95 ± 5.75 vs. 78.45 ± 5.43 years, p < 0.001) and more often had a history of hypertension (77% vs. 83.1%, p < 0.01). Anemia and chronic kidney disease were both more common in women. On the other hand, they less frequently had a prior history of arteriosclerotic cardiovascular disease or comorbidities such as peripheral artery disease and chronic pulmonary disease. Women showed a worse clinical profile on admission, though an invasive approach and in-hospital revascularization were both more often performed in men (p < 0.001). At a one-year follow-up, 1090 patients (15%) had died, without a difference between sexes. Male sex was an independent predictor of mortality (HR = 1.15, 95% CI 1.01 to 1.32, p = 0.035), and there was a significant interaction between sex and DM (p = 0.002). DM was strongly associated with mortality in women (HR: 1.45, 95% CI = 1.18–1.78; p < 0.001), but not in men (HR: 0.98, 95% CI = 0.84–1.14; p = 0.787). In conclusion, DM is associated with mortality in older women with NSTEACS, but not in men. |
format | Online Article Text |
id | pubmed-8509190 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-85091902021-10-13 Prognosis Impact of Diabetes in Elderly Women and Men with Non-ST Elevation Acute Coronary Syndrome Díez-Villanueva, Pablo García-Acuña, Jose María Raposeiras-Roubin, Sergio Barrabés, Jose A. Cordero, Alberto Martínez-Sellés, Manuel Bardají, Alfredo Marín, Francisco Ruiz-Nodar, Juan M. Vicente-Ibarra, Nuria Alonso Salinas, Gonzalo L. Cid-Alvárez, Belén Abu Assi, Emad Formiga, Frances Núñez, Julio Núñez, Eduardo Ariza-Solé, Albert Sanchis, Juan J Clin Med Article Few studies have addressed to date the interaction between sex and diabetes mellitus (DM) in the prognosis of elderly patients with non-ST-segment elevation acute coronary syndrome (NSTEACS). Our aim was to address the role of DM in the prognosis of non-selected elderly patients with NSTEACS according to sex. A retrospective analysis from 11 Spanish NSTEACS registries was conducted, including patients aged ≥70 years. The primary end point was one-year all-cause mortality. A total of 7211 patients were included, 2,770 (38.4%) were women, and 39.9% had DM. Compared with the men, the women were older (79.95 ± 5.75 vs. 78.45 ± 5.43 years, p < 0.001) and more often had a history of hypertension (77% vs. 83.1%, p < 0.01). Anemia and chronic kidney disease were both more common in women. On the other hand, they less frequently had a prior history of arteriosclerotic cardiovascular disease or comorbidities such as peripheral artery disease and chronic pulmonary disease. Women showed a worse clinical profile on admission, though an invasive approach and in-hospital revascularization were both more often performed in men (p < 0.001). At a one-year follow-up, 1090 patients (15%) had died, without a difference between sexes. Male sex was an independent predictor of mortality (HR = 1.15, 95% CI 1.01 to 1.32, p = 0.035), and there was a significant interaction between sex and DM (p = 0.002). DM was strongly associated with mortality in women (HR: 1.45, 95% CI = 1.18–1.78; p < 0.001), but not in men (HR: 0.98, 95% CI = 0.84–1.14; p = 0.787). In conclusion, DM is associated with mortality in older women with NSTEACS, but not in men. MDPI 2021-09-26 /pmc/articles/PMC8509190/ /pubmed/34640420 http://dx.doi.org/10.3390/jcm10194403 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Díez-Villanueva, Pablo García-Acuña, Jose María Raposeiras-Roubin, Sergio Barrabés, Jose A. Cordero, Alberto Martínez-Sellés, Manuel Bardají, Alfredo Marín, Francisco Ruiz-Nodar, Juan M. Vicente-Ibarra, Nuria Alonso Salinas, Gonzalo L. Cid-Alvárez, Belén Abu Assi, Emad Formiga, Frances Núñez, Julio Núñez, Eduardo Ariza-Solé, Albert Sanchis, Juan Prognosis Impact of Diabetes in Elderly Women and Men with Non-ST Elevation Acute Coronary Syndrome |
title | Prognosis Impact of Diabetes in Elderly Women and Men with Non-ST Elevation Acute Coronary Syndrome |
title_full | Prognosis Impact of Diabetes in Elderly Women and Men with Non-ST Elevation Acute Coronary Syndrome |
title_fullStr | Prognosis Impact of Diabetes in Elderly Women and Men with Non-ST Elevation Acute Coronary Syndrome |
title_full_unstemmed | Prognosis Impact of Diabetes in Elderly Women and Men with Non-ST Elevation Acute Coronary Syndrome |
title_short | Prognosis Impact of Diabetes in Elderly Women and Men with Non-ST Elevation Acute Coronary Syndrome |
title_sort | prognosis impact of diabetes in elderly women and men with non-st elevation acute coronary syndrome |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8509190/ https://www.ncbi.nlm.nih.gov/pubmed/34640420 http://dx.doi.org/10.3390/jcm10194403 |
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