Cargando…

Mindfulness-Based Stress Reduction for Systemic Lupus Erythematosus: A Mixed-Methods Pilot Randomized Controlled Trial of an Adapted Protocol

Background: The psychological effects of systemic lupus erythematosus (SLE) are tremendous. This pilot mixed-methods randomized controlled trial aimed to evaluate the effects of a mindfulness-based stress reduction (MBSR) adapted protocol on psychological distress among SLE patients. Methods: 26 SLE...

Descripción completa

Detalles Bibliográficos
Autores principales: Taub, Renen, Horesh, Danny, Rubin, Noa, Glick, Ittai, Reem, Orit, Shriqui, Gitit, Agmon-Levin, Nancy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8509215/
https://www.ncbi.nlm.nih.gov/pubmed/34640468
http://dx.doi.org/10.3390/jcm10194450
_version_ 1784582283201609728
author Taub, Renen
Horesh, Danny
Rubin, Noa
Glick, Ittai
Reem, Orit
Shriqui, Gitit
Agmon-Levin, Nancy
author_facet Taub, Renen
Horesh, Danny
Rubin, Noa
Glick, Ittai
Reem, Orit
Shriqui, Gitit
Agmon-Levin, Nancy
author_sort Taub, Renen
collection PubMed
description Background: The psychological effects of systemic lupus erythematosus (SLE) are tremendous. This pilot mixed-methods randomized controlled trial aimed to evaluate the effects of a mindfulness-based stress reduction (MBSR) adapted protocol on psychological distress among SLE patients. Methods: 26 SLE patients were randomly assigned to MBSR group therapy (n = 15) or a waitlist (WL) group (n = 11). An adapted MBSR protocol for SLE was employed. Three measurements were conducted: pre-intervention, post-intervention and 6-months follow up. A sub-sample (n = 12) also underwent qualitative interviews to assess their subjective experience of MBSR. Results: Compared to the WL, the MBSR group showed greater improvements in quality of life, psychological inflexibility in pain and SLE-related shame. Analysis among MBSR participants showed additional improvements in SLE symptoms and illness perception. Improvements in psychological inflexibility in pain and SLE-related shame remained stable over six months, and depression levels declined steadily from pre-treatment to follow-up. Qualitative analysis showed improvements in mindfulness components (e.g., less impulsivity, higher acceptance), as well as reduced stress following MBSR. Conclusions: These results reveal the significant therapeutic potential of MBSR for SLE patients. With its emphasis on acceptance of negative physical and emotional states, mindfulness practice is a promising treatment option for SLE, which needs to be further applied and studied.
format Online
Article
Text
id pubmed-8509215
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-85092152021-10-13 Mindfulness-Based Stress Reduction for Systemic Lupus Erythematosus: A Mixed-Methods Pilot Randomized Controlled Trial of an Adapted Protocol Taub, Renen Horesh, Danny Rubin, Noa Glick, Ittai Reem, Orit Shriqui, Gitit Agmon-Levin, Nancy J Clin Med Article Background: The psychological effects of systemic lupus erythematosus (SLE) are tremendous. This pilot mixed-methods randomized controlled trial aimed to evaluate the effects of a mindfulness-based stress reduction (MBSR) adapted protocol on psychological distress among SLE patients. Methods: 26 SLE patients were randomly assigned to MBSR group therapy (n = 15) or a waitlist (WL) group (n = 11). An adapted MBSR protocol for SLE was employed. Three measurements were conducted: pre-intervention, post-intervention and 6-months follow up. A sub-sample (n = 12) also underwent qualitative interviews to assess their subjective experience of MBSR. Results: Compared to the WL, the MBSR group showed greater improvements in quality of life, psychological inflexibility in pain and SLE-related shame. Analysis among MBSR participants showed additional improvements in SLE symptoms and illness perception. Improvements in psychological inflexibility in pain and SLE-related shame remained stable over six months, and depression levels declined steadily from pre-treatment to follow-up. Qualitative analysis showed improvements in mindfulness components (e.g., less impulsivity, higher acceptance), as well as reduced stress following MBSR. Conclusions: These results reveal the significant therapeutic potential of MBSR for SLE patients. With its emphasis on acceptance of negative physical and emotional states, mindfulness practice is a promising treatment option for SLE, which needs to be further applied and studied. MDPI 2021-09-28 /pmc/articles/PMC8509215/ /pubmed/34640468 http://dx.doi.org/10.3390/jcm10194450 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Taub, Renen
Horesh, Danny
Rubin, Noa
Glick, Ittai
Reem, Orit
Shriqui, Gitit
Agmon-Levin, Nancy
Mindfulness-Based Stress Reduction for Systemic Lupus Erythematosus: A Mixed-Methods Pilot Randomized Controlled Trial of an Adapted Protocol
title Mindfulness-Based Stress Reduction for Systemic Lupus Erythematosus: A Mixed-Methods Pilot Randomized Controlled Trial of an Adapted Protocol
title_full Mindfulness-Based Stress Reduction for Systemic Lupus Erythematosus: A Mixed-Methods Pilot Randomized Controlled Trial of an Adapted Protocol
title_fullStr Mindfulness-Based Stress Reduction for Systemic Lupus Erythematosus: A Mixed-Methods Pilot Randomized Controlled Trial of an Adapted Protocol
title_full_unstemmed Mindfulness-Based Stress Reduction for Systemic Lupus Erythematosus: A Mixed-Methods Pilot Randomized Controlled Trial of an Adapted Protocol
title_short Mindfulness-Based Stress Reduction for Systemic Lupus Erythematosus: A Mixed-Methods Pilot Randomized Controlled Trial of an Adapted Protocol
title_sort mindfulness-based stress reduction for systemic lupus erythematosus: a mixed-methods pilot randomized controlled trial of an adapted protocol
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8509215/
https://www.ncbi.nlm.nih.gov/pubmed/34640468
http://dx.doi.org/10.3390/jcm10194450
work_keys_str_mv AT taubrenen mindfulnessbasedstressreductionforsystemiclupuserythematosusamixedmethodspilotrandomizedcontrolledtrialofanadaptedprotocol
AT horeshdanny mindfulnessbasedstressreductionforsystemiclupuserythematosusamixedmethodspilotrandomizedcontrolledtrialofanadaptedprotocol
AT rubinnoa mindfulnessbasedstressreductionforsystemiclupuserythematosusamixedmethodspilotrandomizedcontrolledtrialofanadaptedprotocol
AT glickittai mindfulnessbasedstressreductionforsystemiclupuserythematosusamixedmethodspilotrandomizedcontrolledtrialofanadaptedprotocol
AT reemorit mindfulnessbasedstressreductionforsystemiclupuserythematosusamixedmethodspilotrandomizedcontrolledtrialofanadaptedprotocol
AT shriquigitit mindfulnessbasedstressreductionforsystemiclupuserythematosusamixedmethodspilotrandomizedcontrolledtrialofanadaptedprotocol
AT agmonlevinnancy mindfulnessbasedstressreductionforsystemiclupuserythematosusamixedmethodspilotrandomizedcontrolledtrialofanadaptedprotocol