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Host–Viral Interactions in the Pathogenesis of Ulcerative Colitis
Ulcerative colitis is characterized by relapsing and remitting colonic mucosal inflammation. During the early stages of viral infection, innate immune defenses are activated, leading to the rapid release of cytokines and the subsequent initiation of downstream responses including inflammation. Previ...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8509287/ https://www.ncbi.nlm.nih.gov/pubmed/34639191 http://dx.doi.org/10.3390/ijms221910851 |
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author | Bruland, Torunn Østvik, Ann Elisabet Sandvik, Arne Kristian Hansen, Marianne Doré |
author_facet | Bruland, Torunn Østvik, Ann Elisabet Sandvik, Arne Kristian Hansen, Marianne Doré |
author_sort | Bruland, Torunn |
collection | PubMed |
description | Ulcerative colitis is characterized by relapsing and remitting colonic mucosal inflammation. During the early stages of viral infection, innate immune defenses are activated, leading to the rapid release of cytokines and the subsequent initiation of downstream responses including inflammation. Previously, intestinal viruses were thought to be either detrimental or neutral to the host. However, persisting viruses may have a role as resident commensals and confer protective immunity during inflammation. On the other hand, the dysregulation of gut mucosal immune responses to viruses can trigger excessive, pathogenic inflammation. The purpose of this review is to discuss virus-induced innate immune responses that are at play in ulcerative colitis. |
format | Online Article Text |
id | pubmed-8509287 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-85092872021-10-13 Host–Viral Interactions in the Pathogenesis of Ulcerative Colitis Bruland, Torunn Østvik, Ann Elisabet Sandvik, Arne Kristian Hansen, Marianne Doré Int J Mol Sci Review Ulcerative colitis is characterized by relapsing and remitting colonic mucosal inflammation. During the early stages of viral infection, innate immune defenses are activated, leading to the rapid release of cytokines and the subsequent initiation of downstream responses including inflammation. Previously, intestinal viruses were thought to be either detrimental or neutral to the host. However, persisting viruses may have a role as resident commensals and confer protective immunity during inflammation. On the other hand, the dysregulation of gut mucosal immune responses to viruses can trigger excessive, pathogenic inflammation. The purpose of this review is to discuss virus-induced innate immune responses that are at play in ulcerative colitis. MDPI 2021-10-07 /pmc/articles/PMC8509287/ /pubmed/34639191 http://dx.doi.org/10.3390/ijms221910851 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Bruland, Torunn Østvik, Ann Elisabet Sandvik, Arne Kristian Hansen, Marianne Doré Host–Viral Interactions in the Pathogenesis of Ulcerative Colitis |
title | Host–Viral Interactions in the Pathogenesis of Ulcerative Colitis |
title_full | Host–Viral Interactions in the Pathogenesis of Ulcerative Colitis |
title_fullStr | Host–Viral Interactions in the Pathogenesis of Ulcerative Colitis |
title_full_unstemmed | Host–Viral Interactions in the Pathogenesis of Ulcerative Colitis |
title_short | Host–Viral Interactions in the Pathogenesis of Ulcerative Colitis |
title_sort | host–viral interactions in the pathogenesis of ulcerative colitis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8509287/ https://www.ncbi.nlm.nih.gov/pubmed/34639191 http://dx.doi.org/10.3390/ijms221910851 |
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