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Host–Viral Interactions in the Pathogenesis of Ulcerative Colitis

Ulcerative colitis is characterized by relapsing and remitting colonic mucosal inflammation. During the early stages of viral infection, innate immune defenses are activated, leading to the rapid release of cytokines and the subsequent initiation of downstream responses including inflammation. Previ...

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Detalles Bibliográficos
Autores principales: Bruland, Torunn, Østvik, Ann Elisabet, Sandvik, Arne Kristian, Hansen, Marianne Doré
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8509287/
https://www.ncbi.nlm.nih.gov/pubmed/34639191
http://dx.doi.org/10.3390/ijms221910851
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author Bruland, Torunn
Østvik, Ann Elisabet
Sandvik, Arne Kristian
Hansen, Marianne Doré
author_facet Bruland, Torunn
Østvik, Ann Elisabet
Sandvik, Arne Kristian
Hansen, Marianne Doré
author_sort Bruland, Torunn
collection PubMed
description Ulcerative colitis is characterized by relapsing and remitting colonic mucosal inflammation. During the early stages of viral infection, innate immune defenses are activated, leading to the rapid release of cytokines and the subsequent initiation of downstream responses including inflammation. Previously, intestinal viruses were thought to be either detrimental or neutral to the host. However, persisting viruses may have a role as resident commensals and confer protective immunity during inflammation. On the other hand, the dysregulation of gut mucosal immune responses to viruses can trigger excessive, pathogenic inflammation. The purpose of this review is to discuss virus-induced innate immune responses that are at play in ulcerative colitis.
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spelling pubmed-85092872021-10-13 Host–Viral Interactions in the Pathogenesis of Ulcerative Colitis Bruland, Torunn Østvik, Ann Elisabet Sandvik, Arne Kristian Hansen, Marianne Doré Int J Mol Sci Review Ulcerative colitis is characterized by relapsing and remitting colonic mucosal inflammation. During the early stages of viral infection, innate immune defenses are activated, leading to the rapid release of cytokines and the subsequent initiation of downstream responses including inflammation. Previously, intestinal viruses were thought to be either detrimental or neutral to the host. However, persisting viruses may have a role as resident commensals and confer protective immunity during inflammation. On the other hand, the dysregulation of gut mucosal immune responses to viruses can trigger excessive, pathogenic inflammation. The purpose of this review is to discuss virus-induced innate immune responses that are at play in ulcerative colitis. MDPI 2021-10-07 /pmc/articles/PMC8509287/ /pubmed/34639191 http://dx.doi.org/10.3390/ijms221910851 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Bruland, Torunn
Østvik, Ann Elisabet
Sandvik, Arne Kristian
Hansen, Marianne Doré
Host–Viral Interactions in the Pathogenesis of Ulcerative Colitis
title Host–Viral Interactions in the Pathogenesis of Ulcerative Colitis
title_full Host–Viral Interactions in the Pathogenesis of Ulcerative Colitis
title_fullStr Host–Viral Interactions in the Pathogenesis of Ulcerative Colitis
title_full_unstemmed Host–Viral Interactions in the Pathogenesis of Ulcerative Colitis
title_short Host–Viral Interactions in the Pathogenesis of Ulcerative Colitis
title_sort host–viral interactions in the pathogenesis of ulcerative colitis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8509287/
https://www.ncbi.nlm.nih.gov/pubmed/34639191
http://dx.doi.org/10.3390/ijms221910851
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