Inhibition of Mitochondrial Metabolism Leads to Selective Eradication of Cells Adapted to Acidic Microenvironment

Metabolic transformation of cancer cells leads to the accumulation of lactate and significant acidification in the tumor microenvironment. Both lactate and acidosis have a well-documented impact on cancer progression and negative patient prognosis. Here, we report that cancer cells adapted to acidos...

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Detalles Bibliográficos
Autores principales: Koncošová, Martina, Vrzáčková, Nikola, Křížová, Ivana, Tomášová, Petra, Rimpelová, Silvie, Dvořák, Aleš, Vítek, Libor, Rumlová, Michaela, Ruml, Tomáš, Zelenka, Jaroslav
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8509312/
https://www.ncbi.nlm.nih.gov/pubmed/34639130
http://dx.doi.org/10.3390/ijms221910790

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8509312/
https://www.ncbi.nlm.nih.gov/pubmed/34639130
http://dx.doi.org/10.3390/ijms221910790

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