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Why Did All Patients with Atrial Fibrillation and High Risk of Stroke Not Receive Oral Anticoagulants? Results of the Polish Atrial Fibrillation (POL-AF) Registry

Background: Most atrial fibrillation (AF) patients are at high risk of thromboembolic, and the use of oral anticoagulants (OACs) is advised in such cases. The aim of the study was to evaluate the frequency at which OACs were used in patients with AF and high risk thromboembolic complications, and id...

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Autores principales: Szpotowicz, Anna, Gorczyca, Iwona, Jelonek, Olga, Uziębło-Życzkowska, Beata, Maciorowska, Małgorzata, Wójcik, Maciej, Błaszczyk, Robert, Kapłon-Cieślicka, Agnieszka, Gawałko, Monika, Budnik, Monika, Tokarek, Tomasz, Rajtar-Salwa, Renata, Bil, Jacek, Wojewódzki, Michał, Bednarski, Janusz, Bakuła-Ostalska, Elwira, Tomaszuk-Kazberuk, Anna, Szyszkowska, Anna, Wełnicki, Marcin, Mamcarz, Artur, Krzciuk, Małgorzata, Wożakowska-Kapłon, Beata
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8509343/
https://www.ncbi.nlm.nih.gov/pubmed/34640629
http://dx.doi.org/10.3390/jcm10194611
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author Szpotowicz, Anna
Gorczyca, Iwona
Jelonek, Olga
Uziębło-Życzkowska, Beata
Maciorowska, Małgorzata
Wójcik, Maciej
Błaszczyk, Robert
Kapłon-Cieślicka, Agnieszka
Gawałko, Monika
Budnik, Monika
Tokarek, Tomasz
Rajtar-Salwa, Renata
Bil, Jacek
Wojewódzki, Michał
Bednarski, Janusz
Bakuła-Ostalska, Elwira
Tomaszuk-Kazberuk, Anna
Szyszkowska, Anna
Wełnicki, Marcin
Mamcarz, Artur
Krzciuk, Małgorzata
Wożakowska-Kapłon, Beata
author_facet Szpotowicz, Anna
Gorczyca, Iwona
Jelonek, Olga
Uziębło-Życzkowska, Beata
Maciorowska, Małgorzata
Wójcik, Maciej
Błaszczyk, Robert
Kapłon-Cieślicka, Agnieszka
Gawałko, Monika
Budnik, Monika
Tokarek, Tomasz
Rajtar-Salwa, Renata
Bil, Jacek
Wojewódzki, Michał
Bednarski, Janusz
Bakuła-Ostalska, Elwira
Tomaszuk-Kazberuk, Anna
Szyszkowska, Anna
Wełnicki, Marcin
Mamcarz, Artur
Krzciuk, Małgorzata
Wożakowska-Kapłon, Beata
author_sort Szpotowicz, Anna
collection PubMed
description Background: Most atrial fibrillation (AF) patients are at high risk of thromboembolic, and the use of oral anticoagulants (OACs) is advised in such cases. The aim of the study was to evaluate the frequency at which OACs were used in patients with AF and high risk thromboembolic complications, and identify factors that result in OACs not being used in the researched group of patients. Methods: The prospective, multicenter and non-interventional POL-AF registry is a study that includes AF patients from ten Polish cardiology centers. They were consecutively hospitalized between January and December of 2019. All the patients in the study were of high stroke risk. Results: A total of 3614 patients with AF and high stroke risk were included. Among the total study population, 91.5% received OAC therapy; antiplatelet therapy was prescribed for 3.7% of patients, heparin for 2.7%, and 2.1% of patients did not receive any stroke prevention therapy. Independent predictors of no OAC prescription were intracranial bleeding (OR 0.15, 95%CI 0.07–0.35, p < 0.001), gastrointestinal bleeding (OR 0.25, 95%CI 0.17–0.37, p < 0.001), cancer (OR 0.37, 95%CI 0.25–0.55, p < 0.001), hospitalization due to acute coronary syndrome (OR 0.48, 95%CI 0.33–0.69, p < 0.001), and anemia (OR 0.62, 95%CI 0.48–0.81, p < 0.001). Conclusions: Most AF patients with a high thromboembolic risk received OACs. The factors predisposing a lack of OAC use in these patients were conditions that significantly increased the risk of bleeding complications.
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spelling pubmed-85093432021-10-13 Why Did All Patients with Atrial Fibrillation and High Risk of Stroke Not Receive Oral Anticoagulants? Results of the Polish Atrial Fibrillation (POL-AF) Registry Szpotowicz, Anna Gorczyca, Iwona Jelonek, Olga Uziębło-Życzkowska, Beata Maciorowska, Małgorzata Wójcik, Maciej Błaszczyk, Robert Kapłon-Cieślicka, Agnieszka Gawałko, Monika Budnik, Monika Tokarek, Tomasz Rajtar-Salwa, Renata Bil, Jacek Wojewódzki, Michał Bednarski, Janusz Bakuła-Ostalska, Elwira Tomaszuk-Kazberuk, Anna Szyszkowska, Anna Wełnicki, Marcin Mamcarz, Artur Krzciuk, Małgorzata Wożakowska-Kapłon, Beata J Clin Med Article Background: Most atrial fibrillation (AF) patients are at high risk of thromboembolic, and the use of oral anticoagulants (OACs) is advised in such cases. The aim of the study was to evaluate the frequency at which OACs were used in patients with AF and high risk thromboembolic complications, and identify factors that result in OACs not being used in the researched group of patients. Methods: The prospective, multicenter and non-interventional POL-AF registry is a study that includes AF patients from ten Polish cardiology centers. They were consecutively hospitalized between January and December of 2019. All the patients in the study were of high stroke risk. Results: A total of 3614 patients with AF and high stroke risk were included. Among the total study population, 91.5% received OAC therapy; antiplatelet therapy was prescribed for 3.7% of patients, heparin for 2.7%, and 2.1% of patients did not receive any stroke prevention therapy. Independent predictors of no OAC prescription were intracranial bleeding (OR 0.15, 95%CI 0.07–0.35, p < 0.001), gastrointestinal bleeding (OR 0.25, 95%CI 0.17–0.37, p < 0.001), cancer (OR 0.37, 95%CI 0.25–0.55, p < 0.001), hospitalization due to acute coronary syndrome (OR 0.48, 95%CI 0.33–0.69, p < 0.001), and anemia (OR 0.62, 95%CI 0.48–0.81, p < 0.001). Conclusions: Most AF patients with a high thromboembolic risk received OACs. The factors predisposing a lack of OAC use in these patients were conditions that significantly increased the risk of bleeding complications. MDPI 2021-10-08 /pmc/articles/PMC8509343/ /pubmed/34640629 http://dx.doi.org/10.3390/jcm10194611 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Szpotowicz, Anna
Gorczyca, Iwona
Jelonek, Olga
Uziębło-Życzkowska, Beata
Maciorowska, Małgorzata
Wójcik, Maciej
Błaszczyk, Robert
Kapłon-Cieślicka, Agnieszka
Gawałko, Monika
Budnik, Monika
Tokarek, Tomasz
Rajtar-Salwa, Renata
Bil, Jacek
Wojewódzki, Michał
Bednarski, Janusz
Bakuła-Ostalska, Elwira
Tomaszuk-Kazberuk, Anna
Szyszkowska, Anna
Wełnicki, Marcin
Mamcarz, Artur
Krzciuk, Małgorzata
Wożakowska-Kapłon, Beata
Why Did All Patients with Atrial Fibrillation and High Risk of Stroke Not Receive Oral Anticoagulants? Results of the Polish Atrial Fibrillation (POL-AF) Registry
title Why Did All Patients with Atrial Fibrillation and High Risk of Stroke Not Receive Oral Anticoagulants? Results of the Polish Atrial Fibrillation (POL-AF) Registry
title_full Why Did All Patients with Atrial Fibrillation and High Risk of Stroke Not Receive Oral Anticoagulants? Results of the Polish Atrial Fibrillation (POL-AF) Registry
title_fullStr Why Did All Patients with Atrial Fibrillation and High Risk of Stroke Not Receive Oral Anticoagulants? Results of the Polish Atrial Fibrillation (POL-AF) Registry
title_full_unstemmed Why Did All Patients with Atrial Fibrillation and High Risk of Stroke Not Receive Oral Anticoagulants? Results of the Polish Atrial Fibrillation (POL-AF) Registry
title_short Why Did All Patients with Atrial Fibrillation and High Risk of Stroke Not Receive Oral Anticoagulants? Results of the Polish Atrial Fibrillation (POL-AF) Registry
title_sort why did all patients with atrial fibrillation and high risk of stroke not receive oral anticoagulants? results of the polish atrial fibrillation (pol-af) registry
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8509343/
https://www.ncbi.nlm.nih.gov/pubmed/34640629
http://dx.doi.org/10.3390/jcm10194611
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