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Endothelial Activation and Stress Index (EASIX) as an Early Predictor for Mortality and Overall Survival in Hematological and Non-Hematological Patients with COVID-19: Multicenter Cohort Study

COVID-19, as a disease involving the endothelium of multiple organs, is characterized by high mortality rates among hospitalized patients. Patients with hematological malignancies are particularly at risk of an unfavorable course of COVID-19. The endothelial activation and stress index (EASIX) score...

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Autores principales: Kalicińska, Elżbieta, Biernat, Monika, Rybka, Justyna, Zińczuk, Aleksander, Janocha-Litwin, Justyna, Rosiek-Biegus, Marta, Morawska, Marta, Waszczuk-Gajda, Anna, Drozd-Sokołowska, Joanna, Szukalski, Łukasz, Rymko, Marcin, Jabłonowska, Paula, Simon, Krzysztof, Wróbel, Tomasz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8509351/
https://www.ncbi.nlm.nih.gov/pubmed/34640390
http://dx.doi.org/10.3390/jcm10194373
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author Kalicińska, Elżbieta
Biernat, Monika
Rybka, Justyna
Zińczuk, Aleksander
Janocha-Litwin, Justyna
Rosiek-Biegus, Marta
Morawska, Marta
Waszczuk-Gajda, Anna
Drozd-Sokołowska, Joanna
Szukalski, Łukasz
Rymko, Marcin
Jabłonowska, Paula
Simon, Krzysztof
Wróbel, Tomasz
author_facet Kalicińska, Elżbieta
Biernat, Monika
Rybka, Justyna
Zińczuk, Aleksander
Janocha-Litwin, Justyna
Rosiek-Biegus, Marta
Morawska, Marta
Waszczuk-Gajda, Anna
Drozd-Sokołowska, Joanna
Szukalski, Łukasz
Rymko, Marcin
Jabłonowska, Paula
Simon, Krzysztof
Wróbel, Tomasz
author_sort Kalicińska, Elżbieta
collection PubMed
description COVID-19, as a disease involving the endothelium of multiple organs, is characterized by high mortality rates among hospitalized patients. Patients with hematological malignancies are particularly at risk of an unfavorable course of COVID-19. The endothelial activation and stress index (EASIX) score has been used as a simple predictor of overall survival (OS) in specific groups of hematological cancer patients. EASIX, as a biomarker of endothelial dysfunction, might play a prognostic role in patients with COVID-19. Here, we performed a comprehensive retrospective analysis of the EASIX score in 523 hospitalized COVID-19 patients with or without coexisting hematological cancer. Hematological cancer COVID-19 patients had higher EASIX scores compared to the overall population with COVID-19. In hematological patients, EASIX was a strong predictor of the occurrence of sepsis during COVID-19. Our findings demonstrated EASIX as a strong predictor of intensive care unit admission, in-hospital mortality, the occurrence of acute renal failure and the need for hemodialysis, both in hematological and non-hematological COVID-19 patients. Patients with a high EASIX score on COVID-19 diagnosis had significantly inferior OS compared to patients with low EASIX. We showed for the first time that EASIX might serve as a simple, universal prognostic tool of OS in both hematological and non-hematological COVID-19 patients.
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spelling pubmed-85093512021-10-13 Endothelial Activation and Stress Index (EASIX) as an Early Predictor for Mortality and Overall Survival in Hematological and Non-Hematological Patients with COVID-19: Multicenter Cohort Study Kalicińska, Elżbieta Biernat, Monika Rybka, Justyna Zińczuk, Aleksander Janocha-Litwin, Justyna Rosiek-Biegus, Marta Morawska, Marta Waszczuk-Gajda, Anna Drozd-Sokołowska, Joanna Szukalski, Łukasz Rymko, Marcin Jabłonowska, Paula Simon, Krzysztof Wróbel, Tomasz J Clin Med Article COVID-19, as a disease involving the endothelium of multiple organs, is characterized by high mortality rates among hospitalized patients. Patients with hematological malignancies are particularly at risk of an unfavorable course of COVID-19. The endothelial activation and stress index (EASIX) score has been used as a simple predictor of overall survival (OS) in specific groups of hematological cancer patients. EASIX, as a biomarker of endothelial dysfunction, might play a prognostic role in patients with COVID-19. Here, we performed a comprehensive retrospective analysis of the EASIX score in 523 hospitalized COVID-19 patients with or without coexisting hematological cancer. Hematological cancer COVID-19 patients had higher EASIX scores compared to the overall population with COVID-19. In hematological patients, EASIX was a strong predictor of the occurrence of sepsis during COVID-19. Our findings demonstrated EASIX as a strong predictor of intensive care unit admission, in-hospital mortality, the occurrence of acute renal failure and the need for hemodialysis, both in hematological and non-hematological COVID-19 patients. Patients with a high EASIX score on COVID-19 diagnosis had significantly inferior OS compared to patients with low EASIX. We showed for the first time that EASIX might serve as a simple, universal prognostic tool of OS in both hematological and non-hematological COVID-19 patients. MDPI 2021-09-24 /pmc/articles/PMC8509351/ /pubmed/34640390 http://dx.doi.org/10.3390/jcm10194373 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kalicińska, Elżbieta
Biernat, Monika
Rybka, Justyna
Zińczuk, Aleksander
Janocha-Litwin, Justyna
Rosiek-Biegus, Marta
Morawska, Marta
Waszczuk-Gajda, Anna
Drozd-Sokołowska, Joanna
Szukalski, Łukasz
Rymko, Marcin
Jabłonowska, Paula
Simon, Krzysztof
Wróbel, Tomasz
Endothelial Activation and Stress Index (EASIX) as an Early Predictor for Mortality and Overall Survival in Hematological and Non-Hematological Patients with COVID-19: Multicenter Cohort Study
title Endothelial Activation and Stress Index (EASIX) as an Early Predictor for Mortality and Overall Survival in Hematological and Non-Hematological Patients with COVID-19: Multicenter Cohort Study
title_full Endothelial Activation and Stress Index (EASIX) as an Early Predictor for Mortality and Overall Survival in Hematological and Non-Hematological Patients with COVID-19: Multicenter Cohort Study
title_fullStr Endothelial Activation and Stress Index (EASIX) as an Early Predictor for Mortality and Overall Survival in Hematological and Non-Hematological Patients with COVID-19: Multicenter Cohort Study
title_full_unstemmed Endothelial Activation and Stress Index (EASIX) as an Early Predictor for Mortality and Overall Survival in Hematological and Non-Hematological Patients with COVID-19: Multicenter Cohort Study
title_short Endothelial Activation and Stress Index (EASIX) as an Early Predictor for Mortality and Overall Survival in Hematological and Non-Hematological Patients with COVID-19: Multicenter Cohort Study
title_sort endothelial activation and stress index (easix) as an early predictor for mortality and overall survival in hematological and non-hematological patients with covid-19: multicenter cohort study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8509351/
https://www.ncbi.nlm.nih.gov/pubmed/34640390
http://dx.doi.org/10.3390/jcm10194373
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