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Delirium in Critically Ill Patients with and without COVID-19—A Retrospective Analysis
Background: Delirium complicating the course of Intensive care unit (ICU) therapy is a known driver of morbidity and mortality. It has been speculated that infection with the neurotrophic SARS-CoV-2 might promote delirium. Methods: Retrospective registry analysis including all patients treated at le...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8509381/ https://www.ncbi.nlm.nih.gov/pubmed/34640428 http://dx.doi.org/10.3390/jcm10194412 |
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author | Jäckel, Markus Aicher, Nico Biever, Paul Marc Heine, Laura Bemtgen, Xavier Rilinger, Jonathan Zotzmann, Viviane Supady, Alexander Stachon, Peter Wengenmayer, Tobias Bode, Christoph Staudacher, Dawid Leander |
author_facet | Jäckel, Markus Aicher, Nico Biever, Paul Marc Heine, Laura Bemtgen, Xavier Rilinger, Jonathan Zotzmann, Viviane Supady, Alexander Stachon, Peter Wengenmayer, Tobias Bode, Christoph Staudacher, Dawid Leander |
author_sort | Jäckel, Markus |
collection | PubMed |
description | Background: Delirium complicating the course of Intensive care unit (ICU) therapy is a known driver of morbidity and mortality. It has been speculated that infection with the neurotrophic SARS-CoV-2 might promote delirium. Methods: Retrospective registry analysis including all patients treated at least 48 h on a medical intensive care unit. The primary endpoint was development of delirium as diagnosed by Nursing Delirium screening scale ≥2. Results were confirmed by propensity score matching. Results: 542 patients were included. The primary endpoint was reached in 352/542 (64.9%) patients, without significant differences between COVID-19 patients and non-COVID-19 patients (51.4% and 65.9%, respectively, p = 0.07) and correlated with prolonged ICU stay in both groups. In a subgroup of patients with ICU stay >10 days delirium was significantly lower in COVID-19 patients (p ≤ 0.01). After adjustment for confounders, COVID-19 correlated independently with less ICU delirium (p ≤ 0.01). In the propensity score matched cohort, patients with COVID-19 had significantly lower delirium incidence compared to the matched control patients (p ≤ 0.01). Conclusion: Delirium is frequent in critically ill patients with and without COVID-19 treated at an intensive care unit. Data suggests that COVID-19 itself is not a driver of delirium per se. |
format | Online Article Text |
id | pubmed-8509381 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-85093812021-10-13 Delirium in Critically Ill Patients with and without COVID-19—A Retrospective Analysis Jäckel, Markus Aicher, Nico Biever, Paul Marc Heine, Laura Bemtgen, Xavier Rilinger, Jonathan Zotzmann, Viviane Supady, Alexander Stachon, Peter Wengenmayer, Tobias Bode, Christoph Staudacher, Dawid Leander J Clin Med Article Background: Delirium complicating the course of Intensive care unit (ICU) therapy is a known driver of morbidity and mortality. It has been speculated that infection with the neurotrophic SARS-CoV-2 might promote delirium. Methods: Retrospective registry analysis including all patients treated at least 48 h on a medical intensive care unit. The primary endpoint was development of delirium as diagnosed by Nursing Delirium screening scale ≥2. Results were confirmed by propensity score matching. Results: 542 patients were included. The primary endpoint was reached in 352/542 (64.9%) patients, without significant differences between COVID-19 patients and non-COVID-19 patients (51.4% and 65.9%, respectively, p = 0.07) and correlated with prolonged ICU stay in both groups. In a subgroup of patients with ICU stay >10 days delirium was significantly lower in COVID-19 patients (p ≤ 0.01). After adjustment for confounders, COVID-19 correlated independently with less ICU delirium (p ≤ 0.01). In the propensity score matched cohort, patients with COVID-19 had significantly lower delirium incidence compared to the matched control patients (p ≤ 0.01). Conclusion: Delirium is frequent in critically ill patients with and without COVID-19 treated at an intensive care unit. Data suggests that COVID-19 itself is not a driver of delirium per se. MDPI 2021-09-26 /pmc/articles/PMC8509381/ /pubmed/34640428 http://dx.doi.org/10.3390/jcm10194412 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Jäckel, Markus Aicher, Nico Biever, Paul Marc Heine, Laura Bemtgen, Xavier Rilinger, Jonathan Zotzmann, Viviane Supady, Alexander Stachon, Peter Wengenmayer, Tobias Bode, Christoph Staudacher, Dawid Leander Delirium in Critically Ill Patients with and without COVID-19—A Retrospective Analysis |
title | Delirium in Critically Ill Patients with and without COVID-19—A Retrospective Analysis |
title_full | Delirium in Critically Ill Patients with and without COVID-19—A Retrospective Analysis |
title_fullStr | Delirium in Critically Ill Patients with and without COVID-19—A Retrospective Analysis |
title_full_unstemmed | Delirium in Critically Ill Patients with and without COVID-19—A Retrospective Analysis |
title_short | Delirium in Critically Ill Patients with and without COVID-19—A Retrospective Analysis |
title_sort | delirium in critically ill patients with and without covid-19—a retrospective analysis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8509381/ https://www.ncbi.nlm.nih.gov/pubmed/34640428 http://dx.doi.org/10.3390/jcm10194412 |
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