Synthesis of Azulene Derivatives from 2H-Cyclohepta[b]furan-2-ones as Starting Materials: Their Reactivity and Properties

A variety of synthetic methods have been developed for azulene derivatives due to their potential applications in pharmaceuticals and organic materials. Particularly, 2H-cyclohepta[b]furan-2-one and its derivatives have been frequently used as promising precursors for the synthesis of azulenes. In t...

Descripción completa

Detalles Bibliográficos
Autores principales: Shoji, Taku, Ito, Shunji, Yasunami, Masafumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8509482/
https://www.ncbi.nlm.nih.gov/pubmed/34639027
http://dx.doi.org/10.3390/ijms221910686
_version_ 1784582352186376192
author Shoji, Taku
Ito, Shunji
Yasunami, Masafumi
author_facet Shoji, Taku
Ito, Shunji
Yasunami, Masafumi
author_sort Shoji, Taku
collection PubMed
description A variety of synthetic methods have been developed for azulene derivatives due to their potential applications in pharmaceuticals and organic materials. Particularly, 2H-cyclohepta[b]furan-2-one and its derivatives have been frequently used as promising precursors for the synthesis of azulenes. In this review, we describe the development of the synthesis of azulenes by the reaction of 2H-cyclohepta[b]furan-2-ones with olefins, active methylenes, enamines, and silyl enol ethers as well as their reactivity and properties.
format Online
Article
Text
id pubmed-8509482
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-85094822021-10-13 Synthesis of Azulene Derivatives from 2H-Cyclohepta[b]furan-2-ones as Starting Materials: Their Reactivity and Properties Shoji, Taku Ito, Shunji Yasunami, Masafumi Int J Mol Sci Review A variety of synthetic methods have been developed for azulene derivatives due to their potential applications in pharmaceuticals and organic materials. Particularly, 2H-cyclohepta[b]furan-2-one and its derivatives have been frequently used as promising precursors for the synthesis of azulenes. In this review, we describe the development of the synthesis of azulenes by the reaction of 2H-cyclohepta[b]furan-2-ones with olefins, active methylenes, enamines, and silyl enol ethers as well as their reactivity and properties. MDPI 2021-10-01 /pmc/articles/PMC8509482/ /pubmed/34639027 http://dx.doi.org/10.3390/ijms221910686 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Shoji, Taku
Ito, Shunji
Yasunami, Masafumi
Synthesis of Azulene Derivatives from 2H-Cyclohepta[b]furan-2-ones as Starting Materials: Their Reactivity and Properties
title Synthesis of Azulene Derivatives from 2H-Cyclohepta[b]furan-2-ones as Starting Materials: Their Reactivity and Properties
title_full Synthesis of Azulene Derivatives from 2H-Cyclohepta[b]furan-2-ones as Starting Materials: Their Reactivity and Properties
title_fullStr Synthesis of Azulene Derivatives from 2H-Cyclohepta[b]furan-2-ones as Starting Materials: Their Reactivity and Properties
title_full_unstemmed Synthesis of Azulene Derivatives from 2H-Cyclohepta[b]furan-2-ones as Starting Materials: Their Reactivity and Properties
title_short Synthesis of Azulene Derivatives from 2H-Cyclohepta[b]furan-2-ones as Starting Materials: Their Reactivity and Properties
title_sort synthesis of azulene derivatives from 2h-cyclohepta[b]furan-2-ones as starting materials: their reactivity and properties
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8509482/
https://www.ncbi.nlm.nih.gov/pubmed/34639027
http://dx.doi.org/10.3390/ijms221910686
work_keys_str_mv AT shojitaku synthesisofazulenederivativesfrom2hcycloheptabfuran2onesasstartingmaterialstheirreactivityandproperties
AT itoshunji synthesisofazulenederivativesfrom2hcycloheptabfuran2onesasstartingmaterialstheirreactivityandproperties
AT yasunamimasafumi synthesisofazulenederivativesfrom2hcycloheptabfuran2onesasstartingmaterialstheirreactivityandproperties

Ejemplares similares