Cargando…

Epidemiology and Management of Chronic Thromboembolic Pulmonary Hypertension in Greece. Real-World Data from the Hellenic Pulmonary Hypertension Registry (HOPE)

Chronic Thromboembolic Pulmonary Hypertension (CTEPH) is a rare disease with poor prognosis if left untreated, characterized by pulmonary vascular bed obstruction due to unresolving thromboembolic material. The Hellenic pulmonary hypertension registry (HOPE) was launched in Greece in early 2015 and...

Descripción completa

Detalles Bibliográficos
Autores principales: Demerouti, Eftychia, Karyofyllis, Panagiotis, Voudris, Vassilios, Boutsikou, Maria, Anastasiadis, George, Anthi, Anastasia, Arvanitaki, Alexandra, Athanassopoulos, George, Avgeropoulou, Aikaterini, Brili, Styliani, Feloukidis, Christos, Frantzeskaki, Frantzeska, Karatasakis, George, Karvounis, Haralambos, Konstantonis, Dimitrios, Mitrouska, Ioanna, Mouratoglou, Sophia, Naka, Katerina K., Orfanos, Stylianos E., Panagiotidou, Evangelia, Pitsiou, Georgia, Pitsis, Antonios, Stamatopoulou, Vagia, Stanopoulos, Ioannis, Thomaidis, Adina, Tsangaris, Iraklis, Tsiapras, Dimitrios, Giannakoulas, George, Manginas, Athanassios
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8509504/
https://www.ncbi.nlm.nih.gov/pubmed/34640577
http://dx.doi.org/10.3390/jcm10194547
_version_ 1784582357689303040
author Demerouti, Eftychia
Karyofyllis, Panagiotis
Voudris, Vassilios
Boutsikou, Maria
Anastasiadis, George
Anthi, Anastasia
Arvanitaki, Alexandra
Athanassopoulos, George
Avgeropoulou, Aikaterini
Brili, Styliani
Feloukidis, Christos
Frantzeskaki, Frantzeska
Karatasakis, George
Karvounis, Haralambos
Konstantonis, Dimitrios
Mitrouska, Ioanna
Mouratoglou, Sophia
Naka, Katerina K.
Orfanos, Stylianos E.
Panagiotidou, Evangelia
Pitsiou, Georgia
Pitsis, Antonios
Stamatopoulou, Vagia
Stanopoulos, Ioannis
Thomaidis, Adina
Tsangaris, Iraklis
Tsiapras, Dimitrios
Giannakoulas, George
Manginas, Athanassios
author_facet Demerouti, Eftychia
Karyofyllis, Panagiotis
Voudris, Vassilios
Boutsikou, Maria
Anastasiadis, George
Anthi, Anastasia
Arvanitaki, Alexandra
Athanassopoulos, George
Avgeropoulou, Aikaterini
Brili, Styliani
Feloukidis, Christos
Frantzeskaki, Frantzeska
Karatasakis, George
Karvounis, Haralambos
Konstantonis, Dimitrios
Mitrouska, Ioanna
Mouratoglou, Sophia
Naka, Katerina K.
Orfanos, Stylianos E.
Panagiotidou, Evangelia
Pitsiou, Georgia
Pitsis, Antonios
Stamatopoulou, Vagia
Stanopoulos, Ioannis
Thomaidis, Adina
Tsangaris, Iraklis
Tsiapras, Dimitrios
Giannakoulas, George
Manginas, Athanassios
author_sort Demerouti, Eftychia
collection PubMed
description Chronic Thromboembolic Pulmonary Hypertension (CTEPH) is a rare disease with poor prognosis if left untreated, characterized by pulmonary vascular bed obstruction due to unresolving thromboembolic material. The Hellenic pulmonary hypertension registry (HOPE) was launched in Greece in early 2015 and enrolls patients from all pulmonary hypertension subgroups in Greece. In total, 98 patients with CTEPH were enrolled from January 2015 until November 2019. Of these patients, 55.1% represented incident population, 50% were classified in the World Health Organization functional class II and 49% had a history of acute pulmonary embolism. The median values of pulmonary vascular resistance (PVR) and cardiac index were 7.4 (4.8) WU and 2.4 (1.0) L/min/m(2), respectively, the mean diffusing capacity for carbon monoxide was 74.8 ± 20.6%, the median 6-minute walk distance was 347 (220) meters and the median value of N Terminal-pro brain natriuretic peptide was 506.0 (1450.0) pg/mL. In total, 60.2% of the patients were under pulmonary arterial hypertension-targeted therapy at the time of enrolment; specifically, riociguat was received by 35.7% of the patients and combination therapy was the preferred strategy for 16% of the patients. In total, 74 patients were evaluated for pulmonary endarterectomy (PEA), 34 (45.9%) were assessed as operable but only 23 of those (31.1%) finally underwent PEA. The remaining 40 patients were ineligible for PEA according to the operability assessment and 13 (17.6%) of them underwent balloon pulmonary angioplasty. The age of the non-operable patients was significantly higher than the operable patients (p < 0.001), while there was no significant difference with regard to the history of coagulopathies between the operable and non-operable patients (p = 0.33).
format Online
Article
Text
id pubmed-8509504
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-85095042021-10-13 Epidemiology and Management of Chronic Thromboembolic Pulmonary Hypertension in Greece. Real-World Data from the Hellenic Pulmonary Hypertension Registry (HOPE) Demerouti, Eftychia Karyofyllis, Panagiotis Voudris, Vassilios Boutsikou, Maria Anastasiadis, George Anthi, Anastasia Arvanitaki, Alexandra Athanassopoulos, George Avgeropoulou, Aikaterini Brili, Styliani Feloukidis, Christos Frantzeskaki, Frantzeska Karatasakis, George Karvounis, Haralambos Konstantonis, Dimitrios Mitrouska, Ioanna Mouratoglou, Sophia Naka, Katerina K. Orfanos, Stylianos E. Panagiotidou, Evangelia Pitsiou, Georgia Pitsis, Antonios Stamatopoulou, Vagia Stanopoulos, Ioannis Thomaidis, Adina Tsangaris, Iraklis Tsiapras, Dimitrios Giannakoulas, George Manginas, Athanassios J Clin Med Article Chronic Thromboembolic Pulmonary Hypertension (CTEPH) is a rare disease with poor prognosis if left untreated, characterized by pulmonary vascular bed obstruction due to unresolving thromboembolic material. The Hellenic pulmonary hypertension registry (HOPE) was launched in Greece in early 2015 and enrolls patients from all pulmonary hypertension subgroups in Greece. In total, 98 patients with CTEPH were enrolled from January 2015 until November 2019. Of these patients, 55.1% represented incident population, 50% were classified in the World Health Organization functional class II and 49% had a history of acute pulmonary embolism. The median values of pulmonary vascular resistance (PVR) and cardiac index were 7.4 (4.8) WU and 2.4 (1.0) L/min/m(2), respectively, the mean diffusing capacity for carbon monoxide was 74.8 ± 20.6%, the median 6-minute walk distance was 347 (220) meters and the median value of N Terminal-pro brain natriuretic peptide was 506.0 (1450.0) pg/mL. In total, 60.2% of the patients were under pulmonary arterial hypertension-targeted therapy at the time of enrolment; specifically, riociguat was received by 35.7% of the patients and combination therapy was the preferred strategy for 16% of the patients. In total, 74 patients were evaluated for pulmonary endarterectomy (PEA), 34 (45.9%) were assessed as operable but only 23 of those (31.1%) finally underwent PEA. The remaining 40 patients were ineligible for PEA according to the operability assessment and 13 (17.6%) of them underwent balloon pulmonary angioplasty. The age of the non-operable patients was significantly higher than the operable patients (p < 0.001), while there was no significant difference with regard to the history of coagulopathies between the operable and non-operable patients (p = 0.33). MDPI 2021-09-30 /pmc/articles/PMC8509504/ /pubmed/34640577 http://dx.doi.org/10.3390/jcm10194547 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Demerouti, Eftychia
Karyofyllis, Panagiotis
Voudris, Vassilios
Boutsikou, Maria
Anastasiadis, George
Anthi, Anastasia
Arvanitaki, Alexandra
Athanassopoulos, George
Avgeropoulou, Aikaterini
Brili, Styliani
Feloukidis, Christos
Frantzeskaki, Frantzeska
Karatasakis, George
Karvounis, Haralambos
Konstantonis, Dimitrios
Mitrouska, Ioanna
Mouratoglou, Sophia
Naka, Katerina K.
Orfanos, Stylianos E.
Panagiotidou, Evangelia
Pitsiou, Georgia
Pitsis, Antonios
Stamatopoulou, Vagia
Stanopoulos, Ioannis
Thomaidis, Adina
Tsangaris, Iraklis
Tsiapras, Dimitrios
Giannakoulas, George
Manginas, Athanassios
Epidemiology and Management of Chronic Thromboembolic Pulmonary Hypertension in Greece. Real-World Data from the Hellenic Pulmonary Hypertension Registry (HOPE)
title Epidemiology and Management of Chronic Thromboembolic Pulmonary Hypertension in Greece. Real-World Data from the Hellenic Pulmonary Hypertension Registry (HOPE)
title_full Epidemiology and Management of Chronic Thromboembolic Pulmonary Hypertension in Greece. Real-World Data from the Hellenic Pulmonary Hypertension Registry (HOPE)
title_fullStr Epidemiology and Management of Chronic Thromboembolic Pulmonary Hypertension in Greece. Real-World Data from the Hellenic Pulmonary Hypertension Registry (HOPE)
title_full_unstemmed Epidemiology and Management of Chronic Thromboembolic Pulmonary Hypertension in Greece. Real-World Data from the Hellenic Pulmonary Hypertension Registry (HOPE)
title_short Epidemiology and Management of Chronic Thromboembolic Pulmonary Hypertension in Greece. Real-World Data from the Hellenic Pulmonary Hypertension Registry (HOPE)
title_sort epidemiology and management of chronic thromboembolic pulmonary hypertension in greece. real-world data from the hellenic pulmonary hypertension registry (hope)
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8509504/
https://www.ncbi.nlm.nih.gov/pubmed/34640577
http://dx.doi.org/10.3390/jcm10194547
work_keys_str_mv AT demeroutieftychia epidemiologyandmanagementofchronicthromboembolicpulmonaryhypertensioningreecerealworlddatafromthehellenicpulmonaryhypertensionregistryhope
AT karyofyllispanagiotis epidemiologyandmanagementofchronicthromboembolicpulmonaryhypertensioningreecerealworlddatafromthehellenicpulmonaryhypertensionregistryhope
AT voudrisvassilios epidemiologyandmanagementofchronicthromboembolicpulmonaryhypertensioningreecerealworlddatafromthehellenicpulmonaryhypertensionregistryhope
AT boutsikoumaria epidemiologyandmanagementofchronicthromboembolicpulmonaryhypertensioningreecerealworlddatafromthehellenicpulmonaryhypertensionregistryhope
AT anastasiadisgeorge epidemiologyandmanagementofchronicthromboembolicpulmonaryhypertensioningreecerealworlddatafromthehellenicpulmonaryhypertensionregistryhope
AT anthianastasia epidemiologyandmanagementofchronicthromboembolicpulmonaryhypertensioningreecerealworlddatafromthehellenicpulmonaryhypertensionregistryhope
AT arvanitakialexandra epidemiologyandmanagementofchronicthromboembolicpulmonaryhypertensioningreecerealworlddatafromthehellenicpulmonaryhypertensionregistryhope
AT athanassopoulosgeorge epidemiologyandmanagementofchronicthromboembolicpulmonaryhypertensioningreecerealworlddatafromthehellenicpulmonaryhypertensionregistryhope
AT avgeropoulouaikaterini epidemiologyandmanagementofchronicthromboembolicpulmonaryhypertensioningreecerealworlddatafromthehellenicpulmonaryhypertensionregistryhope
AT brilistyliani epidemiologyandmanagementofchronicthromboembolicpulmonaryhypertensioningreecerealworlddatafromthehellenicpulmonaryhypertensionregistryhope
AT feloukidischristos epidemiologyandmanagementofchronicthromboembolicpulmonaryhypertensioningreecerealworlddatafromthehellenicpulmonaryhypertensionregistryhope
AT frantzeskakifrantzeska epidemiologyandmanagementofchronicthromboembolicpulmonaryhypertensioningreecerealworlddatafromthehellenicpulmonaryhypertensionregistryhope
AT karatasakisgeorge epidemiologyandmanagementofchronicthromboembolicpulmonaryhypertensioningreecerealworlddatafromthehellenicpulmonaryhypertensionregistryhope
AT karvounisharalambos epidemiologyandmanagementofchronicthromboembolicpulmonaryhypertensioningreecerealworlddatafromthehellenicpulmonaryhypertensionregistryhope
AT konstantonisdimitrios epidemiologyandmanagementofchronicthromboembolicpulmonaryhypertensioningreecerealworlddatafromthehellenicpulmonaryhypertensionregistryhope
AT mitrouskaioanna epidemiologyandmanagementofchronicthromboembolicpulmonaryhypertensioningreecerealworlddatafromthehellenicpulmonaryhypertensionregistryhope
AT mouratoglousophia epidemiologyandmanagementofchronicthromboembolicpulmonaryhypertensioningreecerealworlddatafromthehellenicpulmonaryhypertensionregistryhope
AT nakakaterinak epidemiologyandmanagementofchronicthromboembolicpulmonaryhypertensioningreecerealworlddatafromthehellenicpulmonaryhypertensionregistryhope
AT orfanosstylianose epidemiologyandmanagementofchronicthromboembolicpulmonaryhypertensioningreecerealworlddatafromthehellenicpulmonaryhypertensionregistryhope
AT panagiotidouevangelia epidemiologyandmanagementofchronicthromboembolicpulmonaryhypertensioningreecerealworlddatafromthehellenicpulmonaryhypertensionregistryhope
AT pitsiougeorgia epidemiologyandmanagementofchronicthromboembolicpulmonaryhypertensioningreecerealworlddatafromthehellenicpulmonaryhypertensionregistryhope
AT pitsisantonios epidemiologyandmanagementofchronicthromboembolicpulmonaryhypertensioningreecerealworlddatafromthehellenicpulmonaryhypertensionregistryhope
AT stamatopoulouvagia epidemiologyandmanagementofchronicthromboembolicpulmonaryhypertensioningreecerealworlddatafromthehellenicpulmonaryhypertensionregistryhope
AT stanopoulosioannis epidemiologyandmanagementofchronicthromboembolicpulmonaryhypertensioningreecerealworlddatafromthehellenicpulmonaryhypertensionregistryhope
AT thomaidisadina epidemiologyandmanagementofchronicthromboembolicpulmonaryhypertensioningreecerealworlddatafromthehellenicpulmonaryhypertensionregistryhope
AT tsangarisiraklis epidemiologyandmanagementofchronicthromboembolicpulmonaryhypertensioningreecerealworlddatafromthehellenicpulmonaryhypertensionregistryhope
AT tsiaprasdimitrios epidemiologyandmanagementofchronicthromboembolicpulmonaryhypertensioningreecerealworlddatafromthehellenicpulmonaryhypertensionregistryhope
AT giannakoulasgeorge epidemiologyandmanagementofchronicthromboembolicpulmonaryhypertensioningreecerealworlddatafromthehellenicpulmonaryhypertensionregistryhope
AT manginasathanassios epidemiologyandmanagementofchronicthromboembolicpulmonaryhypertensioningreecerealworlddatafromthehellenicpulmonaryhypertensionregistryhope