NLRC4 GOF Mutations, a Challenging Diagnosis from Neonatal Age to Adulthood

The NLRC4 inflammasome is part of the human immune innate system. Its activation leads to the cleavage of pro-inflammatory cytokines IL-1β and IL-18, promoting inflammation. NLRC4 gain-of-function (GOF) mutations have been associated with early-onset recurrent fever, recurrent macrophagic activation...

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Detalles Bibliográficos
Autores principales: Bardet, Juliette, Laverdure, Noémie, Fusaro, Mathieu, Picard, Capucine, Garnier, Lorna, Viel, Sébastien, Collardeau-Frachon, Sophie, Guillebon, Jean-Marie De, Durieu, Isabelle, Casari-Thery, Clémence, Mortamet, Guillaume, Laurent, Audrey, Belot, Alexandre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8509521/
https://www.ncbi.nlm.nih.gov/pubmed/34640385
http://dx.doi.org/10.3390/jcm10194369

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