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Clinical and Epidemiological Features of Tuberculous Pleural Effusion in Alicante, Spain
We aimed to (1) evaluate the incidence of tuberculous pleural effusion (TPE) over 25 years in our centre; (2) measure the yield of different diagnostic techniques; (3) compare TPE features between immigrant and native patients. Retrospective study of patients who underwent diagnostic thoracentesis a...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8509524/ https://www.ncbi.nlm.nih.gov/pubmed/34640410 http://dx.doi.org/10.3390/jcm10194392 |
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author | Chiner, Eusebi Nomdedeu, Miriam Vañes, Sandra Pastor, Esther Esteban, Violeta Castelló, Carmen Boira, Ignacio Molina, Virginia Arriero, Juan M. Sancho-Chust, Jose N. |
author_facet | Chiner, Eusebi Nomdedeu, Miriam Vañes, Sandra Pastor, Esther Esteban, Violeta Castelló, Carmen Boira, Ignacio Molina, Virginia Arriero, Juan M. Sancho-Chust, Jose N. |
author_sort | Chiner, Eusebi |
collection | PubMed |
description | We aimed to (1) evaluate the incidence of tuberculous pleural effusion (TPE) over 25 years in our centre; (2) measure the yield of different diagnostic techniques; (3) compare TPE features between immigrant and native patients. Retrospective study of patients who underwent diagnostic thoracentesis and pleural biopsy in our hospital between 1995 and 2020. TPE was diagnosed in 71 patients (65% natives, 35% immigrants). Onset was acute in 35%, subacute in 26% and prolonged in 39%. Radiological features were atypical in 42%. Thoracentesis specimens were lymphocyte-predominant in 84.5% of patients, with elevated adenosine deaminase in 75% of patients. Diagnostic yield of pleural biopsy was 78%. Compared with native patients, more immigrants had previous contact with TB (54% vs. 17%, p = 0.001), prior TB (21% vs. 4%, p < 0.02) and atypical radiological features (58% vs. 34%, p < 0.03). TPE incidence was six times higher in the immigrant population (6.7 vs. 1.1 per 100,000 person-years, p < 0.001). TPE has an acute onset and sometimes atypical radiological features. Pleural biopsy has the highest diagnostic yield. Reactivation, prior contact with TB, atypical radiological features, complications, and positive microbiology results are more common in immigrant patients. |
format | Online Article Text |
id | pubmed-8509524 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-85095242021-10-13 Clinical and Epidemiological Features of Tuberculous Pleural Effusion in Alicante, Spain Chiner, Eusebi Nomdedeu, Miriam Vañes, Sandra Pastor, Esther Esteban, Violeta Castelló, Carmen Boira, Ignacio Molina, Virginia Arriero, Juan M. Sancho-Chust, Jose N. J Clin Med Article We aimed to (1) evaluate the incidence of tuberculous pleural effusion (TPE) over 25 years in our centre; (2) measure the yield of different diagnostic techniques; (3) compare TPE features between immigrant and native patients. Retrospective study of patients who underwent diagnostic thoracentesis and pleural biopsy in our hospital between 1995 and 2020. TPE was diagnosed in 71 patients (65% natives, 35% immigrants). Onset was acute in 35%, subacute in 26% and prolonged in 39%. Radiological features were atypical in 42%. Thoracentesis specimens were lymphocyte-predominant in 84.5% of patients, with elevated adenosine deaminase in 75% of patients. Diagnostic yield of pleural biopsy was 78%. Compared with native patients, more immigrants had previous contact with TB (54% vs. 17%, p = 0.001), prior TB (21% vs. 4%, p < 0.02) and atypical radiological features (58% vs. 34%, p < 0.03). TPE incidence was six times higher in the immigrant population (6.7 vs. 1.1 per 100,000 person-years, p < 0.001). TPE has an acute onset and sometimes atypical radiological features. Pleural biopsy has the highest diagnostic yield. Reactivation, prior contact with TB, atypical radiological features, complications, and positive microbiology results are more common in immigrant patients. MDPI 2021-09-26 /pmc/articles/PMC8509524/ /pubmed/34640410 http://dx.doi.org/10.3390/jcm10194392 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Chiner, Eusebi Nomdedeu, Miriam Vañes, Sandra Pastor, Esther Esteban, Violeta Castelló, Carmen Boira, Ignacio Molina, Virginia Arriero, Juan M. Sancho-Chust, Jose N. Clinical and Epidemiological Features of Tuberculous Pleural Effusion in Alicante, Spain |
title | Clinical and Epidemiological Features of Tuberculous Pleural Effusion in Alicante, Spain |
title_full | Clinical and Epidemiological Features of Tuberculous Pleural Effusion in Alicante, Spain |
title_fullStr | Clinical and Epidemiological Features of Tuberculous Pleural Effusion in Alicante, Spain |
title_full_unstemmed | Clinical and Epidemiological Features of Tuberculous Pleural Effusion in Alicante, Spain |
title_short | Clinical and Epidemiological Features of Tuberculous Pleural Effusion in Alicante, Spain |
title_sort | clinical and epidemiological features of tuberculous pleural effusion in alicante, spain |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8509524/ https://www.ncbi.nlm.nih.gov/pubmed/34640410 http://dx.doi.org/10.3390/jcm10194392 |
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