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Clinical and Epidemiological Features of Tuberculous Pleural Effusion in Alicante, Spain

We aimed to (1) evaluate the incidence of tuberculous pleural effusion (TPE) over 25 years in our centre; (2) measure the yield of different diagnostic techniques; (3) compare TPE features between immigrant and native patients. Retrospective study of patients who underwent diagnostic thoracentesis a...

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Autores principales: Chiner, Eusebi, Nomdedeu, Miriam, Vañes, Sandra, Pastor, Esther, Esteban, Violeta, Castelló, Carmen, Boira, Ignacio, Molina, Virginia, Arriero, Juan M., Sancho-Chust, Jose N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8509524/
https://www.ncbi.nlm.nih.gov/pubmed/34640410
http://dx.doi.org/10.3390/jcm10194392
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author Chiner, Eusebi
Nomdedeu, Miriam
Vañes, Sandra
Pastor, Esther
Esteban, Violeta
Castelló, Carmen
Boira, Ignacio
Molina, Virginia
Arriero, Juan M.
Sancho-Chust, Jose N.
author_facet Chiner, Eusebi
Nomdedeu, Miriam
Vañes, Sandra
Pastor, Esther
Esteban, Violeta
Castelló, Carmen
Boira, Ignacio
Molina, Virginia
Arriero, Juan M.
Sancho-Chust, Jose N.
author_sort Chiner, Eusebi
collection PubMed
description We aimed to (1) evaluate the incidence of tuberculous pleural effusion (TPE) over 25 years in our centre; (2) measure the yield of different diagnostic techniques; (3) compare TPE features between immigrant and native patients. Retrospective study of patients who underwent diagnostic thoracentesis and pleural biopsy in our hospital between 1995 and 2020. TPE was diagnosed in 71 patients (65% natives, 35% immigrants). Onset was acute in 35%, subacute in 26% and prolonged in 39%. Radiological features were atypical in 42%. Thoracentesis specimens were lymphocyte-predominant in 84.5% of patients, with elevated adenosine deaminase in 75% of patients. Diagnostic yield of pleural biopsy was 78%. Compared with native patients, more immigrants had previous contact with TB (54% vs. 17%, p = 0.001), prior TB (21% vs. 4%, p < 0.02) and atypical radiological features (58% vs. 34%, p < 0.03). TPE incidence was six times higher in the immigrant population (6.7 vs. 1.1 per 100,000 person-years, p < 0.001). TPE has an acute onset and sometimes atypical radiological features. Pleural biopsy has the highest diagnostic yield. Reactivation, prior contact with TB, atypical radiological features, complications, and positive microbiology results are more common in immigrant patients.
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spelling pubmed-85095242021-10-13 Clinical and Epidemiological Features of Tuberculous Pleural Effusion in Alicante, Spain Chiner, Eusebi Nomdedeu, Miriam Vañes, Sandra Pastor, Esther Esteban, Violeta Castelló, Carmen Boira, Ignacio Molina, Virginia Arriero, Juan M. Sancho-Chust, Jose N. J Clin Med Article We aimed to (1) evaluate the incidence of tuberculous pleural effusion (TPE) over 25 years in our centre; (2) measure the yield of different diagnostic techniques; (3) compare TPE features between immigrant and native patients. Retrospective study of patients who underwent diagnostic thoracentesis and pleural biopsy in our hospital between 1995 and 2020. TPE was diagnosed in 71 patients (65% natives, 35% immigrants). Onset was acute in 35%, subacute in 26% and prolonged in 39%. Radiological features were atypical in 42%. Thoracentesis specimens were lymphocyte-predominant in 84.5% of patients, with elevated adenosine deaminase in 75% of patients. Diagnostic yield of pleural biopsy was 78%. Compared with native patients, more immigrants had previous contact with TB (54% vs. 17%, p = 0.001), prior TB (21% vs. 4%, p < 0.02) and atypical radiological features (58% vs. 34%, p < 0.03). TPE incidence was six times higher in the immigrant population (6.7 vs. 1.1 per 100,000 person-years, p < 0.001). TPE has an acute onset and sometimes atypical radiological features. Pleural biopsy has the highest diagnostic yield. Reactivation, prior contact with TB, atypical radiological features, complications, and positive microbiology results are more common in immigrant patients. MDPI 2021-09-26 /pmc/articles/PMC8509524/ /pubmed/34640410 http://dx.doi.org/10.3390/jcm10194392 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Chiner, Eusebi
Nomdedeu, Miriam
Vañes, Sandra
Pastor, Esther
Esteban, Violeta
Castelló, Carmen
Boira, Ignacio
Molina, Virginia
Arriero, Juan M.
Sancho-Chust, Jose N.
Clinical and Epidemiological Features of Tuberculous Pleural Effusion in Alicante, Spain
title Clinical and Epidemiological Features of Tuberculous Pleural Effusion in Alicante, Spain
title_full Clinical and Epidemiological Features of Tuberculous Pleural Effusion in Alicante, Spain
title_fullStr Clinical and Epidemiological Features of Tuberculous Pleural Effusion in Alicante, Spain
title_full_unstemmed Clinical and Epidemiological Features of Tuberculous Pleural Effusion in Alicante, Spain
title_short Clinical and Epidemiological Features of Tuberculous Pleural Effusion in Alicante, Spain
title_sort clinical and epidemiological features of tuberculous pleural effusion in alicante, spain
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8509524/
https://www.ncbi.nlm.nih.gov/pubmed/34640410
http://dx.doi.org/10.3390/jcm10194392
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