Cargando…

Utilization of Pharmacological Ascorbate to Enhance Hydrogen Peroxide-Mediated Radiosensitivity in Cancer Therapy

Interest in the use of pharmacological ascorbate as a treatment for cancer has increased considerably since it was introduced by Cameron and Pauling in the 1970s. Recently, pharmacological ascorbate has been used in preclinical and early-phase clinical trials as a selective radiation sensitizer in c...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mehdi, Zain, Petronek, Michael S., Stolwijk, Jeffrey M., Mapuskar, Kranti A., Kalen, Amanda L., Buettner, Garry R., Cullen, Joseph J., Spitz, Douglas R., Buatti, John M., Allen, Bryan G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8509557/ https://www.ncbi.nlm.nih.gov/pubmed/34639220 http://dx.doi.org/10.3390/ijms221910880

Ejemplares similares

BIMG-07. PHARMACOLOGICAL ASCORBATE ENHANCES RADIATION AND TEMOZOLOMIDE EFFECTIVENESS IN GLIOBLASTOMA BY A MECHANISM MEDIATED BY REDOX ACTIVE IRON
por: Allen, Bryan, et al.
Publicado: (2021)

Redox active metals and H(2)O(2) mediate the increased efficacy of pharmacological ascorbate in combination with gemcitabine or radiation in pre-clinical sarcoma models()
por: Schoenfeld, Joshua D., et al.
Publicado: (2017)

Magnetic resonance imaging (MRI) of pharmacological ascorbate-induced iron redox state as a biomarker in subjects undergoing radio-chemotherapy
por: Cushing, Cameron M., et al.
Publicado: (2020)

Magnetite nanoparticles as a kinetically favorable source of iron to enhance GBM response to chemoradiosensitization with pharmacological ascorbate
por: Petronek, M.S., et al.
Publicado: (2023)

Pharmacological ascorbate as a novel therapeutic strategy to enhance cancer immunotherapy
por: Zaher, Amira, et al.
Publicado: (2022)

Linking Cancer Metabolic Dysfunction and Genetic Instability through the Lens of Iron Metabolism
por: Petronek, Michael S., et al.
Publicado: (2019)

Oxidation of ferumoxytol by ionizing radiation releases iron. An electron paramagnetic resonance study
por: Petronek, Michael S, et al.
Publicado: (2022)

Pharmacologic Ascorbate and DNMT Inhibitors Increase DUOX Expression and Peroxide-Mediated Toxicity in Pancreatic Cancer
por: Steers, Garett J., et al.
Publicado: (2023)

The role of mitochondria in pharmacological ascorbate-induced toxicity
por: Du, Juan, et al.
Publicado: (2022)

Pharmacological ascorbate improves the response to platinum-based chemotherapy in advanced stage non-small cell lung cancer
por: Furqan, Muhammad, et al.
Publicado: (2022)

Depletion of Labile Iron Induces Replication Stress and Enhances Responses to Chemoradiation in Non-Small-Cell Lung Cancer
por: Bayanbold, Khaliunaa, et al.
Publicado: (2023)

Augmentation of intracellular iron using iron sucrose enhances the toxicity of pharmacological ascorbate in colon cancer cells
por: Brandt, Kristin E., et al.
Publicado: (2017)

Pharmacological ascorbate and ionizing radiation (IR) increase labile iron in pancreatic cancer()
por: Moser, Justin C., et al.
Publicado: (2013)

Catalase Modulates the Radio-Sensitization of Pancreatic Cancer Cells by Pharmacological Ascorbate
por: Du, Juan, et al.
Publicado: (2021)

Ascorbic acid and tetrahydrobiopterin potentiate the EDHF phenomenon by generating hydrogen peroxide
por: Garry, Ambroise, et al.
Publicado: (2009)

Pharmacological ascorbate inhibits pancreatic cancer metastases via a peroxide-mediated mechanism
por: O’Leary, Brianne R., et al.
Publicado: (2020)

Radioresistance in Glioblastoma and the Development of Radiosensitizers
por: Ali, Md Yousuf, et al.
Publicado: (2020)

Utilization of redox modulating small molecules that selectively act as pro-oxidants in cancer cells to open a therapeutic window for improving cancer therapy
por: Petronek, M.S., et al.
Publicado: (2021)

Superoxide Dismutase Mimetic GC4419 Enhances the Oxidation of Pharmacological Ascorbate and Its Anticancer Effects in an H(2)O(2)-Dependent Manner
por: Heer, Collin D., et al.
Publicado: (2018)

An assay for the rate of removal of extracellular hydrogen peroxide by cells()
por: Wagner, Brett A., et al.
Publicado: (2013)

Triethylenetetramine Synergizes with Pharmacologic Ascorbic Acid in Hydrogen Peroxide Mediated Selective Toxicity to Breast Cancer Cell
por: Wang, Lianlian, et al.
Publicado: (2017)

Tumor cells have decreased ability to metabolize H(2)O(2): Implications for pharmacological ascorbate in cancer therapy
por: Doskey, Claire M., et al.
Publicado: (2016)

In vitro Cytotoxicity and Pharmacokinetic Evaluation of Pharmacological Ascorbate in Dogs
por: Musser, Margaret L., et al.
Publicado: (2019)

Epigenetic effects of pharmacologic ascorbate
por: Steers, Garett J., et al.
Publicado: (2021)

Hydrogen Peroxide Mediates Artemisinin-Derived C-16 Carba-Dimer-Induced Toxicity of Human Cancer Cells
por: Kalen, Amanda L., et al.
Publicado: (2020)

Ketogenic diets as an adjuvant cancer therapy: History and potential mechanism
por: Allen, Bryan G., et al.
Publicado: (2014)

Iron–Sulfur Cluster Biogenesis as a Critical Target in Cancer
por: Petronek, Michael S., et al.
Publicado: (2021)

Polyoxometalate Nanoparticles as a Potential Glioblastoma Therapeutic via Lipid-Mediated Cell Death
por: Petronek, Michael S., et al.
Publicado: (2022)

Direct spectrophotometric measurement of supra-physiological levels of ascorbate in plasma
por: Witmer, Jordan R., et al.
Publicado: (2016)

Redox Regulation of Nrf2 in Cisplatin-Induced Kidney Injury
por: Mapuskar, Kranti A., et al.
Publicado: (2023)

Stability of aqueous solutions of ascorbate for basic research and for intravenous administration
por: Wagner, Brett A., et al.
Publicado: (2023)

Mitochondrial Superoxide Dismutase in Cisplatin-Induced Kidney Injury
por: Mapuskar, Kranti A., et al.
Publicado: (2021)

Peroxiporin Expression Is an Important Factor for Cancer Cell Susceptibility to Therapeutic H(2)O(2): Implications for Pharmacological Ascorbate Therapy
por: Erudaitius, Dieanira, et al.
Publicado: (2017)

Methylseleninic Acid Induces Lipid Peroxidation and Radiation Sensitivity in Head and Neck Cancer Cells
por: Lafin, John T., et al.
Publicado: (2019)

Ascorbate mediates the non-enzymatic reduction of nitrite to nitric oxide
por: Du, Juan, et al.
Publicado: (2023)

Silane- and peroxide-free hydrogen atom transfer hydrogenation using ascorbic acid and cobalt-photoredox dual catalysis
por: Kamei, Yuji, et al.
Publicado: (2021)

Neoadjuvant Radiotherapy-Related Wound Morbidity in Soft Tissue Sarcoma: Perspectives for Radioprotective Agents
por: Callaghan, Cameron M., et al.
Publicado: (2020)

The dual effect of pharmacological ascorbate on radiation: The best of both worlds
por: Cullen, Joseph J.
Publicado: (2018)

Pharmacological Ascorbate Elicits Anti-Cancer Activities against Non-Small Cell Lung Cancer through Hydrogen-Peroxide-Induced-DNA-Damage
por: Sanookpan, Kittipong, et al.
Publicado: (2023)

Auranofin and Pharmacologic Ascorbate as Radiomodulators in the Treatment of Pancreatic Cancer
por: Steers, Garett J., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_24rcanpt1d6v1fnjn30sfv0l71