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Quality of Life in Electrochemotherapy for Cutaneous and Mucosal Head and Neck Tumors
Background: Primary or recurrent head and neck cancer of skin or mucosa represents a challenge for clinicians and could be debilitating for the patient. Electrochemotherapy (ECT) emerged as a local ablative procedure for cutaneous and mucosal head and neck tumors. The aim of this observational study...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8509577/ https://www.ncbi.nlm.nih.gov/pubmed/34640382 http://dx.doi.org/10.3390/jcm10194366 |
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author | Riva, Giuseppe Salonia, Laura Fassone, Elisabetta Sapino, Silvia Piano, Fabrizio Pecorari, Giancarlo |
author_facet | Riva, Giuseppe Salonia, Laura Fassone, Elisabetta Sapino, Silvia Piano, Fabrizio Pecorari, Giancarlo |
author_sort | Riva, Giuseppe |
collection | PubMed |
description | Background: Primary or recurrent head and neck cancer of skin or mucosa represents a challenge for clinicians and could be debilitating for the patient. Electrochemotherapy (ECT) emerged as a local ablative procedure for cutaneous and mucosal head and neck tumors. The aim of this observational study was the evaluation of quality of life (QoL) after ECT in patients without other surgical or radiation options as curative treatment. Materials and methods: The procedure was performed according the ESOPE (European Standard Operating procedure of Electrochemotherapy) protocol. Twenty-seven patients were evaluated before ECT (T0) and 1 (T1), 3 (T2), and 6 (T3) months after the procedure. QoL was assessed by means of the EORTC QLQ-C30 and EORTC QLQ-H&N35 questionnaires. Results: The objective tumor response rate was 48% (11% CR, 37% PR). Bleeding control was achieved in 7/7 patients who experienced bleeding prior to ECT. QoL improvement was observed after the procedure. In particular, global health status and social functioning were higher after ECT (p 0.026 and 0.043), while pain, pain-killers use and appetite loss decreased (p 0.045, 0.025 and 0.002). Conclusion: ECT represents a safe and effective treatment for skin and mucosal head and neck tumors without other curative options. It ensures a good pain and bleeding control without worsening of QoL. |
format | Online Article Text |
id | pubmed-8509577 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-85095772021-10-13 Quality of Life in Electrochemotherapy for Cutaneous and Mucosal Head and Neck Tumors Riva, Giuseppe Salonia, Laura Fassone, Elisabetta Sapino, Silvia Piano, Fabrizio Pecorari, Giancarlo J Clin Med Article Background: Primary or recurrent head and neck cancer of skin or mucosa represents a challenge for clinicians and could be debilitating for the patient. Electrochemotherapy (ECT) emerged as a local ablative procedure for cutaneous and mucosal head and neck tumors. The aim of this observational study was the evaluation of quality of life (QoL) after ECT in patients without other surgical or radiation options as curative treatment. Materials and methods: The procedure was performed according the ESOPE (European Standard Operating procedure of Electrochemotherapy) protocol. Twenty-seven patients were evaluated before ECT (T0) and 1 (T1), 3 (T2), and 6 (T3) months after the procedure. QoL was assessed by means of the EORTC QLQ-C30 and EORTC QLQ-H&N35 questionnaires. Results: The objective tumor response rate was 48% (11% CR, 37% PR). Bleeding control was achieved in 7/7 patients who experienced bleeding prior to ECT. QoL improvement was observed after the procedure. In particular, global health status and social functioning were higher after ECT (p 0.026 and 0.043), while pain, pain-killers use and appetite loss decreased (p 0.045, 0.025 and 0.002). Conclusion: ECT represents a safe and effective treatment for skin and mucosal head and neck tumors without other curative options. It ensures a good pain and bleeding control without worsening of QoL. MDPI 2021-09-24 /pmc/articles/PMC8509577/ /pubmed/34640382 http://dx.doi.org/10.3390/jcm10194366 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Riva, Giuseppe Salonia, Laura Fassone, Elisabetta Sapino, Silvia Piano, Fabrizio Pecorari, Giancarlo Quality of Life in Electrochemotherapy for Cutaneous and Mucosal Head and Neck Tumors |
title | Quality of Life in Electrochemotherapy for Cutaneous and Mucosal Head and Neck Tumors |
title_full | Quality of Life in Electrochemotherapy for Cutaneous and Mucosal Head and Neck Tumors |
title_fullStr | Quality of Life in Electrochemotherapy for Cutaneous and Mucosal Head and Neck Tumors |
title_full_unstemmed | Quality of Life in Electrochemotherapy for Cutaneous and Mucosal Head and Neck Tumors |
title_short | Quality of Life in Electrochemotherapy for Cutaneous and Mucosal Head and Neck Tumors |
title_sort | quality of life in electrochemotherapy for cutaneous and mucosal head and neck tumors |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8509577/ https://www.ncbi.nlm.nih.gov/pubmed/34640382 http://dx.doi.org/10.3390/jcm10194366 |
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