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Involvement of Cutaneous Sensory Corpuscles in Non-Painful and Painful Diabetic Neuropathy
Distal diabetic sensorimotor polyneuropathy (DDSP) is the most prevalent form of diabetic neuropathy, and some of the patients develop gradual pain. Specialized sensory structures present in the skin encode different modalities of somatosensitivity such as temperature, touch, and pain. The cutaneous...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8509589/ https://www.ncbi.nlm.nih.gov/pubmed/34640627 http://dx.doi.org/10.3390/jcm10194609 |
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author | García-Mesa, Yolanda Feito, Jorge González-Gay, Mario Martínez, Irene García-Piqueras, Jorge Martín-Cruces, José Viña, Eliseo Cobo, Teresa García-Suárez, Olivia |
author_facet | García-Mesa, Yolanda Feito, Jorge González-Gay, Mario Martínez, Irene García-Piqueras, Jorge Martín-Cruces, José Viña, Eliseo Cobo, Teresa García-Suárez, Olivia |
author_sort | García-Mesa, Yolanda |
collection | PubMed |
description | Distal diabetic sensorimotor polyneuropathy (DDSP) is the most prevalent form of diabetic neuropathy, and some of the patients develop gradual pain. Specialized sensory structures present in the skin encode different modalities of somatosensitivity such as temperature, touch, and pain. The cutaneous sensory structures responsible for the qualities of mechanosensitivity (fine touch, vibration) are collectively known as cutaneous mechanoreceptors (Meissner corpuscles, Pacinian corpuscles, and Merkel cell–axonal complexes), which results are altered during diabetes. Here, we used immunohistochemistry to analyze the density, localization within the dermis, arrangement of corpuscular components (axons and Schwann-like cells), and expression of putative mechanoproteins (PIEZO2, ASIC2, and TRPV4) in cutaneous mechanoreceptors of subjects suffering clinically diagnosed non-painful and painful distal diabetic sensorimotor polyneuropathy. The number of Meissner corpuscles, Pacinian corpuscles, and Merkel cells was found to be severely decreased in the non-painful presentation of the disease, and almost disappeared in the painful presentation. Furthermore, there was a marked reduction in the expression of axonal and Schwann-like cell markers (with are characteristics of corpuscular denervation) as well as of all investigated mechanoproteins in the non-painful distal diabetic sensorimotor polyneuropathy, and these were absent in the painful form. Taken together, these alterations might explain, at least partly, the impairment of mechanosensitivity system associated with distal diabetic sensorimotor polyneuropathy. Furthermore, our results support that an increasing severity of DDSP may increase the risk of developing painful neuropathic symptoms. However, why the absence of cutaneous mechanoreceptors is associated with pain remains to be elucidated. |
format | Online Article Text |
id | pubmed-8509589 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-85095892021-10-13 Involvement of Cutaneous Sensory Corpuscles in Non-Painful and Painful Diabetic Neuropathy García-Mesa, Yolanda Feito, Jorge González-Gay, Mario Martínez, Irene García-Piqueras, Jorge Martín-Cruces, José Viña, Eliseo Cobo, Teresa García-Suárez, Olivia J Clin Med Article Distal diabetic sensorimotor polyneuropathy (DDSP) is the most prevalent form of diabetic neuropathy, and some of the patients develop gradual pain. Specialized sensory structures present in the skin encode different modalities of somatosensitivity such as temperature, touch, and pain. The cutaneous sensory structures responsible for the qualities of mechanosensitivity (fine touch, vibration) are collectively known as cutaneous mechanoreceptors (Meissner corpuscles, Pacinian corpuscles, and Merkel cell–axonal complexes), which results are altered during diabetes. Here, we used immunohistochemistry to analyze the density, localization within the dermis, arrangement of corpuscular components (axons and Schwann-like cells), and expression of putative mechanoproteins (PIEZO2, ASIC2, and TRPV4) in cutaneous mechanoreceptors of subjects suffering clinically diagnosed non-painful and painful distal diabetic sensorimotor polyneuropathy. The number of Meissner corpuscles, Pacinian corpuscles, and Merkel cells was found to be severely decreased in the non-painful presentation of the disease, and almost disappeared in the painful presentation. Furthermore, there was a marked reduction in the expression of axonal and Schwann-like cell markers (with are characteristics of corpuscular denervation) as well as of all investigated mechanoproteins in the non-painful distal diabetic sensorimotor polyneuropathy, and these were absent in the painful form. Taken together, these alterations might explain, at least partly, the impairment of mechanosensitivity system associated with distal diabetic sensorimotor polyneuropathy. Furthermore, our results support that an increasing severity of DDSP may increase the risk of developing painful neuropathic symptoms. However, why the absence of cutaneous mechanoreceptors is associated with pain remains to be elucidated. MDPI 2021-10-08 /pmc/articles/PMC8509589/ /pubmed/34640627 http://dx.doi.org/10.3390/jcm10194609 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article García-Mesa, Yolanda Feito, Jorge González-Gay, Mario Martínez, Irene García-Piqueras, Jorge Martín-Cruces, José Viña, Eliseo Cobo, Teresa García-Suárez, Olivia Involvement of Cutaneous Sensory Corpuscles in Non-Painful and Painful Diabetic Neuropathy |
title | Involvement of Cutaneous Sensory Corpuscles in Non-Painful and Painful Diabetic Neuropathy |
title_full | Involvement of Cutaneous Sensory Corpuscles in Non-Painful and Painful Diabetic Neuropathy |
title_fullStr | Involvement of Cutaneous Sensory Corpuscles in Non-Painful and Painful Diabetic Neuropathy |
title_full_unstemmed | Involvement of Cutaneous Sensory Corpuscles in Non-Painful and Painful Diabetic Neuropathy |
title_short | Involvement of Cutaneous Sensory Corpuscles in Non-Painful and Painful Diabetic Neuropathy |
title_sort | involvement of cutaneous sensory corpuscles in non-painful and painful diabetic neuropathy |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8509589/ https://www.ncbi.nlm.nih.gov/pubmed/34640627 http://dx.doi.org/10.3390/jcm10194609 |
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