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Involvement of Cutaneous Sensory Corpuscles in Non-Painful and Painful Diabetic Neuropathy

Distal diabetic sensorimotor polyneuropathy (DDSP) is the most prevalent form of diabetic neuropathy, and some of the patients develop gradual pain. Specialized sensory structures present in the skin encode different modalities of somatosensitivity such as temperature, touch, and pain. The cutaneous...

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Autores principales: García-Mesa, Yolanda, Feito, Jorge, González-Gay, Mario, Martínez, Irene, García-Piqueras, Jorge, Martín-Cruces, José, Viña, Eliseo, Cobo, Teresa, García-Suárez, Olivia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8509589/
https://www.ncbi.nlm.nih.gov/pubmed/34640627
http://dx.doi.org/10.3390/jcm10194609
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author García-Mesa, Yolanda
Feito, Jorge
González-Gay, Mario
Martínez, Irene
García-Piqueras, Jorge
Martín-Cruces, José
Viña, Eliseo
Cobo, Teresa
García-Suárez, Olivia
author_facet García-Mesa, Yolanda
Feito, Jorge
González-Gay, Mario
Martínez, Irene
García-Piqueras, Jorge
Martín-Cruces, José
Viña, Eliseo
Cobo, Teresa
García-Suárez, Olivia
author_sort García-Mesa, Yolanda
collection PubMed
description Distal diabetic sensorimotor polyneuropathy (DDSP) is the most prevalent form of diabetic neuropathy, and some of the patients develop gradual pain. Specialized sensory structures present in the skin encode different modalities of somatosensitivity such as temperature, touch, and pain. The cutaneous sensory structures responsible for the qualities of mechanosensitivity (fine touch, vibration) are collectively known as cutaneous mechanoreceptors (Meissner corpuscles, Pacinian corpuscles, and Merkel cell–axonal complexes), which results are altered during diabetes. Here, we used immunohistochemistry to analyze the density, localization within the dermis, arrangement of corpuscular components (axons and Schwann-like cells), and expression of putative mechanoproteins (PIEZO2, ASIC2, and TRPV4) in cutaneous mechanoreceptors of subjects suffering clinically diagnosed non-painful and painful distal diabetic sensorimotor polyneuropathy. The number of Meissner corpuscles, Pacinian corpuscles, and Merkel cells was found to be severely decreased in the non-painful presentation of the disease, and almost disappeared in the painful presentation. Furthermore, there was a marked reduction in the expression of axonal and Schwann-like cell markers (with are characteristics of corpuscular denervation) as well as of all investigated mechanoproteins in the non-painful distal diabetic sensorimotor polyneuropathy, and these were absent in the painful form. Taken together, these alterations might explain, at least partly, the impairment of mechanosensitivity system associated with distal diabetic sensorimotor polyneuropathy. Furthermore, our results support that an increasing severity of DDSP may increase the risk of developing painful neuropathic symptoms. However, why the absence of cutaneous mechanoreceptors is associated with pain remains to be elucidated.
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spelling pubmed-85095892021-10-13 Involvement of Cutaneous Sensory Corpuscles in Non-Painful and Painful Diabetic Neuropathy García-Mesa, Yolanda Feito, Jorge González-Gay, Mario Martínez, Irene García-Piqueras, Jorge Martín-Cruces, José Viña, Eliseo Cobo, Teresa García-Suárez, Olivia J Clin Med Article Distal diabetic sensorimotor polyneuropathy (DDSP) is the most prevalent form of diabetic neuropathy, and some of the patients develop gradual pain. Specialized sensory structures present in the skin encode different modalities of somatosensitivity such as temperature, touch, and pain. The cutaneous sensory structures responsible for the qualities of mechanosensitivity (fine touch, vibration) are collectively known as cutaneous mechanoreceptors (Meissner corpuscles, Pacinian corpuscles, and Merkel cell–axonal complexes), which results are altered during diabetes. Here, we used immunohistochemistry to analyze the density, localization within the dermis, arrangement of corpuscular components (axons and Schwann-like cells), and expression of putative mechanoproteins (PIEZO2, ASIC2, and TRPV4) in cutaneous mechanoreceptors of subjects suffering clinically diagnosed non-painful and painful distal diabetic sensorimotor polyneuropathy. The number of Meissner corpuscles, Pacinian corpuscles, and Merkel cells was found to be severely decreased in the non-painful presentation of the disease, and almost disappeared in the painful presentation. Furthermore, there was a marked reduction in the expression of axonal and Schwann-like cell markers (with are characteristics of corpuscular denervation) as well as of all investigated mechanoproteins in the non-painful distal diabetic sensorimotor polyneuropathy, and these were absent in the painful form. Taken together, these alterations might explain, at least partly, the impairment of mechanosensitivity system associated with distal diabetic sensorimotor polyneuropathy. Furthermore, our results support that an increasing severity of DDSP may increase the risk of developing painful neuropathic symptoms. However, why the absence of cutaneous mechanoreceptors is associated with pain remains to be elucidated. MDPI 2021-10-08 /pmc/articles/PMC8509589/ /pubmed/34640627 http://dx.doi.org/10.3390/jcm10194609 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
García-Mesa, Yolanda
Feito, Jorge
González-Gay, Mario
Martínez, Irene
García-Piqueras, Jorge
Martín-Cruces, José
Viña, Eliseo
Cobo, Teresa
García-Suárez, Olivia
Involvement of Cutaneous Sensory Corpuscles in Non-Painful and Painful Diabetic Neuropathy
title Involvement of Cutaneous Sensory Corpuscles in Non-Painful and Painful Diabetic Neuropathy
title_full Involvement of Cutaneous Sensory Corpuscles in Non-Painful and Painful Diabetic Neuropathy
title_fullStr Involvement of Cutaneous Sensory Corpuscles in Non-Painful and Painful Diabetic Neuropathy
title_full_unstemmed Involvement of Cutaneous Sensory Corpuscles in Non-Painful and Painful Diabetic Neuropathy
title_short Involvement of Cutaneous Sensory Corpuscles in Non-Painful and Painful Diabetic Neuropathy
title_sort involvement of cutaneous sensory corpuscles in non-painful and painful diabetic neuropathy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8509589/
https://www.ncbi.nlm.nih.gov/pubmed/34640627
http://dx.doi.org/10.3390/jcm10194609
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