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Serum Uric Acid Is a Weak Independent Predictor of Overall Survival in Older Adults

Hyperuricemia accompanies many pathologies that contribute to overall death rate. The population-based multifaceted study of older adults in Poland made it possible to assess the effect of serum uric acid (SUA) on overall mortality. The PolSenior study performed between 2007–2011 included 3926 parti...

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Autores principales: Winder, Mateusz, Owczarek, Aleksander J., Mossakowska, Małgorzata, Holecki, Michał, Broczek, Katarzyna, Grodzicki, Tomasz, Zdrojewski, Tomasz, Chudek, Jerzy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8509603/
https://www.ncbi.nlm.nih.gov/pubmed/34640521
http://dx.doi.org/10.3390/jcm10194505
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author Winder, Mateusz
Owczarek, Aleksander J.
Mossakowska, Małgorzata
Holecki, Michał
Broczek, Katarzyna
Grodzicki, Tomasz
Zdrojewski, Tomasz
Chudek, Jerzy
author_facet Winder, Mateusz
Owczarek, Aleksander J.
Mossakowska, Małgorzata
Holecki, Michał
Broczek, Katarzyna
Grodzicki, Tomasz
Zdrojewski, Tomasz
Chudek, Jerzy
author_sort Winder, Mateusz
collection PubMed
description Hyperuricemia accompanies many pathologies that contribute to overall death rate. The population-based multifaceted study of older adults in Poland made it possible to assess the effect of serum uric acid (SUA) on overall mortality. The PolSenior study performed between 2007–2011 included 3926 participants aged 65 years or above (mean age 79 ± 9 years) not treated with xanthin oxidase inhibitors (XOI) who were stratified by sex and SUA concentration into six subgroups increasing by 1 mg/dL. In 2019, survival data were retrieved from the population register. The crude risk of death was significantly higher in men and women with SUA ≥ 7 mg/dL. After adjustment to statistically significant factors, SUA remained a risk factor of death in men with SUA ≥ 8 mg/dL only, potentially due to the limited number of women with high SUA levels. Furthermore, age, heart failure, diabetes, and activities of daily living ≤ 4 pts were identified as factors increasing mortality risk regardless of sex. The risk of death increased also with smoking, past stroke, COPD/asthma, and hs-CRP > 3 mg/dL for men; and eGFR < 45 mL/min/1.73 m(2), mini nutritional assessment ≤ 7 pts, and loop diuretics use for women. Mild hyperuricemia is a significant health status marker and an independent risk factor for overall mortality in older Caucasians not receiving XOI. Increased mortality is mostly limited to subjects with SUA levels ≥ 8 mg/dL.
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spelling pubmed-85096032021-10-13 Serum Uric Acid Is a Weak Independent Predictor of Overall Survival in Older Adults Winder, Mateusz Owczarek, Aleksander J. Mossakowska, Małgorzata Holecki, Michał Broczek, Katarzyna Grodzicki, Tomasz Zdrojewski, Tomasz Chudek, Jerzy J Clin Med Article Hyperuricemia accompanies many pathologies that contribute to overall death rate. The population-based multifaceted study of older adults in Poland made it possible to assess the effect of serum uric acid (SUA) on overall mortality. The PolSenior study performed between 2007–2011 included 3926 participants aged 65 years or above (mean age 79 ± 9 years) not treated with xanthin oxidase inhibitors (XOI) who were stratified by sex and SUA concentration into six subgroups increasing by 1 mg/dL. In 2019, survival data were retrieved from the population register. The crude risk of death was significantly higher in men and women with SUA ≥ 7 mg/dL. After adjustment to statistically significant factors, SUA remained a risk factor of death in men with SUA ≥ 8 mg/dL only, potentially due to the limited number of women with high SUA levels. Furthermore, age, heart failure, diabetes, and activities of daily living ≤ 4 pts were identified as factors increasing mortality risk regardless of sex. The risk of death increased also with smoking, past stroke, COPD/asthma, and hs-CRP > 3 mg/dL for men; and eGFR < 45 mL/min/1.73 m(2), mini nutritional assessment ≤ 7 pts, and loop diuretics use for women. Mild hyperuricemia is a significant health status marker and an independent risk factor for overall mortality in older Caucasians not receiving XOI. Increased mortality is mostly limited to subjects with SUA levels ≥ 8 mg/dL. MDPI 2021-09-29 /pmc/articles/PMC8509603/ /pubmed/34640521 http://dx.doi.org/10.3390/jcm10194505 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Winder, Mateusz
Owczarek, Aleksander J.
Mossakowska, Małgorzata
Holecki, Michał
Broczek, Katarzyna
Grodzicki, Tomasz
Zdrojewski, Tomasz
Chudek, Jerzy
Serum Uric Acid Is a Weak Independent Predictor of Overall Survival in Older Adults
title Serum Uric Acid Is a Weak Independent Predictor of Overall Survival in Older Adults
title_full Serum Uric Acid Is a Weak Independent Predictor of Overall Survival in Older Adults
title_fullStr Serum Uric Acid Is a Weak Independent Predictor of Overall Survival in Older Adults
title_full_unstemmed Serum Uric Acid Is a Weak Independent Predictor of Overall Survival in Older Adults
title_short Serum Uric Acid Is a Weak Independent Predictor of Overall Survival in Older Adults
title_sort serum uric acid is a weak independent predictor of overall survival in older adults
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8509603/
https://www.ncbi.nlm.nih.gov/pubmed/34640521
http://dx.doi.org/10.3390/jcm10194505
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