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Persistent Post-COVID-19 Syndrome in Hemodialyzed Patients—A Longitudinal Cohort Study from the North of Poland

Background: After recovery from COVID-19, patients frequently face so-called “Post-COVID-19 Syndrome” defined by clusters of persistent symptoms lasting for >12 weeks which may arise from any system in the body. The long-term health consequences of COVID-19 in maintenance hemodialyzed (HD) patien...

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Autores principales: Och, Aleksander, Tylicki, Piotr, Polewska, Karolina, Puchalska-Reglińska, Ewelina, Parczewska, Aleksandra, Szabat, Krzysztof, Biedunkiewicz, Bogdan, Dębska-Ślizień, Alicja, Tylicki, Leszek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8509624/
https://www.ncbi.nlm.nih.gov/pubmed/34640471
http://dx.doi.org/10.3390/jcm10194451
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author Och, Aleksander
Tylicki, Piotr
Polewska, Karolina
Puchalska-Reglińska, Ewelina
Parczewska, Aleksandra
Szabat, Krzysztof
Biedunkiewicz, Bogdan
Dębska-Ślizień, Alicja
Tylicki, Leszek
author_facet Och, Aleksander
Tylicki, Piotr
Polewska, Karolina
Puchalska-Reglińska, Ewelina
Parczewska, Aleksandra
Szabat, Krzysztof
Biedunkiewicz, Bogdan
Dębska-Ślizień, Alicja
Tylicki, Leszek
author_sort Och, Aleksander
collection PubMed
description Background: After recovery from COVID-19, patients frequently face so-called “Post-COVID-19 Syndrome” defined by clusters of persistent symptoms lasting for >12 weeks which may arise from any system in the body. The long-term health consequences of COVID-19 in maintenance hemodialyzed (HD) patients remain to be investigated. Methods: In this longitudinal cohort study we described the health consequences in HD patients requiring hospitalization due to COVID-19. They were interviewed three and six months (M3 and M6) after discharge with a series of standardized questionnaires. Results: Of 144 HD patients discharged from the 7th Naval Hospital in Gdansk, 79 participants were enrolled, 39 m (49.4%) and 40 f (50.6%) with a median age of 70.0 (64.0–76.5) and an HD vintage of 40 months (17.5–88). After discharge, 93.7% and 81% reported at least one persistent symptom at M3 and M6, respectively. The most common symptoms were fatigue or muscle weakness (60.76% and 47.04%) and palpitations (40.51% and 30.14%). Dyspnea with an mMRC scale grade of at least 1 was reported by 21.5% before infection, and by 43.03% and 34.25% at M3 and M6, respectively. A decrease in the quality of life was reported in all domains of the EQ-5D-5L questionnaire but mainly in the pain/discomfort and anxiety dimensions. Mean EQ-VAS scores were 69.05, 61.58 and 64.38, respectively. Conclusion: Our study showed that HD patients may still experience persistent symptoms six months after recovery from COVID-19, which can further reduce their already poor health-related quality of life. This study highlights the need for long-term follow-up on these patients for diagnostic and rehabilitation programs.
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spelling pubmed-85096242021-10-13 Persistent Post-COVID-19 Syndrome in Hemodialyzed Patients—A Longitudinal Cohort Study from the North of Poland Och, Aleksander Tylicki, Piotr Polewska, Karolina Puchalska-Reglińska, Ewelina Parczewska, Aleksandra Szabat, Krzysztof Biedunkiewicz, Bogdan Dębska-Ślizień, Alicja Tylicki, Leszek J Clin Med Article Background: After recovery from COVID-19, patients frequently face so-called “Post-COVID-19 Syndrome” defined by clusters of persistent symptoms lasting for >12 weeks which may arise from any system in the body. The long-term health consequences of COVID-19 in maintenance hemodialyzed (HD) patients remain to be investigated. Methods: In this longitudinal cohort study we described the health consequences in HD patients requiring hospitalization due to COVID-19. They were interviewed three and six months (M3 and M6) after discharge with a series of standardized questionnaires. Results: Of 144 HD patients discharged from the 7th Naval Hospital in Gdansk, 79 participants were enrolled, 39 m (49.4%) and 40 f (50.6%) with a median age of 70.0 (64.0–76.5) and an HD vintage of 40 months (17.5–88). After discharge, 93.7% and 81% reported at least one persistent symptom at M3 and M6, respectively. The most common symptoms were fatigue or muscle weakness (60.76% and 47.04%) and palpitations (40.51% and 30.14%). Dyspnea with an mMRC scale grade of at least 1 was reported by 21.5% before infection, and by 43.03% and 34.25% at M3 and M6, respectively. A decrease in the quality of life was reported in all domains of the EQ-5D-5L questionnaire but mainly in the pain/discomfort and anxiety dimensions. Mean EQ-VAS scores were 69.05, 61.58 and 64.38, respectively. Conclusion: Our study showed that HD patients may still experience persistent symptoms six months after recovery from COVID-19, which can further reduce their already poor health-related quality of life. This study highlights the need for long-term follow-up on these patients for diagnostic and rehabilitation programs. MDPI 2021-09-28 /pmc/articles/PMC8509624/ /pubmed/34640471 http://dx.doi.org/10.3390/jcm10194451 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Och, Aleksander
Tylicki, Piotr
Polewska, Karolina
Puchalska-Reglińska, Ewelina
Parczewska, Aleksandra
Szabat, Krzysztof
Biedunkiewicz, Bogdan
Dębska-Ślizień, Alicja
Tylicki, Leszek
Persistent Post-COVID-19 Syndrome in Hemodialyzed Patients—A Longitudinal Cohort Study from the North of Poland
title Persistent Post-COVID-19 Syndrome in Hemodialyzed Patients—A Longitudinal Cohort Study from the North of Poland
title_full Persistent Post-COVID-19 Syndrome in Hemodialyzed Patients—A Longitudinal Cohort Study from the North of Poland
title_fullStr Persistent Post-COVID-19 Syndrome in Hemodialyzed Patients—A Longitudinal Cohort Study from the North of Poland
title_full_unstemmed Persistent Post-COVID-19 Syndrome in Hemodialyzed Patients—A Longitudinal Cohort Study from the North of Poland
title_short Persistent Post-COVID-19 Syndrome in Hemodialyzed Patients—A Longitudinal Cohort Study from the North of Poland
title_sort persistent post-covid-19 syndrome in hemodialyzed patients—a longitudinal cohort study from the north of poland
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8509624/
https://www.ncbi.nlm.nih.gov/pubmed/34640471
http://dx.doi.org/10.3390/jcm10194451
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