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The Netherlands Is on Track to Meet the World Health Organization Hepatitis C Elimination Targets by 2030
Background: The Netherlands strives for hepatitis C virus (HCV) elimination, in accordance with the World Health Organization targets. An accurate estimate when HCV elimination will be reached is elusive. We have embarked on a nationwide HCV elimination project (CELINE) that allowed us to harvest de...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8509638/ https://www.ncbi.nlm.nih.gov/pubmed/34640576 http://dx.doi.org/10.3390/jcm10194562 |
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author | van Dijk, Marleen Brakenhoff, Sylvia M. Isfordink, Cas J. Cheng, Wei-Han Blokzijl, Hans Boland, Greet Dofferhoff, Anthonius S. M. van Hoek, Bart van Nieuwkoop, Cees Sonneveld, Milan J. van der Valk, Marc Drenth, Joost P. H. de Knegt, Robert J. |
author_facet | van Dijk, Marleen Brakenhoff, Sylvia M. Isfordink, Cas J. Cheng, Wei-Han Blokzijl, Hans Boland, Greet Dofferhoff, Anthonius S. M. van Hoek, Bart van Nieuwkoop, Cees Sonneveld, Milan J. van der Valk, Marc Drenth, Joost P. H. de Knegt, Robert J. |
author_sort | van Dijk, Marleen |
collection | PubMed |
description | Background: The Netherlands strives for hepatitis C virus (HCV) elimination, in accordance with the World Health Organization targets. An accurate estimate when HCV elimination will be reached is elusive. We have embarked on a nationwide HCV elimination project (CELINE) that allowed us to harvest detailed data on the Dutch HCV epidemic. This study aims to provide a well-supported timeline towards HCV elimination in The Netherlands. Methods: A previously published Markov model was used, adopting published data and unpublished CELINE project data. Two main scenarios were devised. In the Status Quo scenario, 2020 diagnosis and treatment levels remained constant in subsequent years. In the Gradual Decline scenario, an annual decrease of 10% in both diagnoses and treatments was implemented, starting in 2020. WHO incidence target was disregarded, due to low HCV incidence in The Netherlands (≤5 per 100,000). Results: Following the Status Quo and Gradual Decline scenarios, The Netherlands would meet WHO’s elimination targets by 2027 and 2032, respectively. From 2015 to 2030, liver-related mortality would be reduced by 97% in the Status Quo and 93% in the Gradual Decline scenario. Compared to the Status Quo scenario, the Gradual Decline scenario would result in 12 excess cases of decompensated cirrhosis, 18 excess cases of hepatocellular carcinoma, and 20 excess cases of liver-related death from 2020–2030. Conclusions: The Netherlands is on track to reach HCV elimination by 2030. However, it is vital that HCV elimination remains high on the agenda to ensure adequate numbers of patients are being diagnosed and treated. |
format | Online Article Text |
id | pubmed-8509638 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-85096382021-10-13 The Netherlands Is on Track to Meet the World Health Organization Hepatitis C Elimination Targets by 2030 van Dijk, Marleen Brakenhoff, Sylvia M. Isfordink, Cas J. Cheng, Wei-Han Blokzijl, Hans Boland, Greet Dofferhoff, Anthonius S. M. van Hoek, Bart van Nieuwkoop, Cees Sonneveld, Milan J. van der Valk, Marc Drenth, Joost P. H. de Knegt, Robert J. J Clin Med Article Background: The Netherlands strives for hepatitis C virus (HCV) elimination, in accordance with the World Health Organization targets. An accurate estimate when HCV elimination will be reached is elusive. We have embarked on a nationwide HCV elimination project (CELINE) that allowed us to harvest detailed data on the Dutch HCV epidemic. This study aims to provide a well-supported timeline towards HCV elimination in The Netherlands. Methods: A previously published Markov model was used, adopting published data and unpublished CELINE project data. Two main scenarios were devised. In the Status Quo scenario, 2020 diagnosis and treatment levels remained constant in subsequent years. In the Gradual Decline scenario, an annual decrease of 10% in both diagnoses and treatments was implemented, starting in 2020. WHO incidence target was disregarded, due to low HCV incidence in The Netherlands (≤5 per 100,000). Results: Following the Status Quo and Gradual Decline scenarios, The Netherlands would meet WHO’s elimination targets by 2027 and 2032, respectively. From 2015 to 2030, liver-related mortality would be reduced by 97% in the Status Quo and 93% in the Gradual Decline scenario. Compared to the Status Quo scenario, the Gradual Decline scenario would result in 12 excess cases of decompensated cirrhosis, 18 excess cases of hepatocellular carcinoma, and 20 excess cases of liver-related death from 2020–2030. Conclusions: The Netherlands is on track to reach HCV elimination by 2030. However, it is vital that HCV elimination remains high on the agenda to ensure adequate numbers of patients are being diagnosed and treated. MDPI 2021-09-30 /pmc/articles/PMC8509638/ /pubmed/34640576 http://dx.doi.org/10.3390/jcm10194562 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article van Dijk, Marleen Brakenhoff, Sylvia M. Isfordink, Cas J. Cheng, Wei-Han Blokzijl, Hans Boland, Greet Dofferhoff, Anthonius S. M. van Hoek, Bart van Nieuwkoop, Cees Sonneveld, Milan J. van der Valk, Marc Drenth, Joost P. H. de Knegt, Robert J. The Netherlands Is on Track to Meet the World Health Organization Hepatitis C Elimination Targets by 2030 |
title | The Netherlands Is on Track to Meet the World Health Organization Hepatitis C Elimination Targets by 2030 |
title_full | The Netherlands Is on Track to Meet the World Health Organization Hepatitis C Elimination Targets by 2030 |
title_fullStr | The Netherlands Is on Track to Meet the World Health Organization Hepatitis C Elimination Targets by 2030 |
title_full_unstemmed | The Netherlands Is on Track to Meet the World Health Organization Hepatitis C Elimination Targets by 2030 |
title_short | The Netherlands Is on Track to Meet the World Health Organization Hepatitis C Elimination Targets by 2030 |
title_sort | netherlands is on track to meet the world health organization hepatitis c elimination targets by 2030 |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8509638/ https://www.ncbi.nlm.nih.gov/pubmed/34640576 http://dx.doi.org/10.3390/jcm10194562 |
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