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Still’s Disease Mortality Trends in France, 1979–2016: A Multiple-Cause-of-Death Study

Still’s disease (SD) is often considered a benign disease, with low mortality rates. However, few studies have investigated SD mortality and its causes and most of these have been single-center cohort studies. We sought to examine mortality rates and causes of death among French decedents with SD. W...

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Autores principales: Borciuch, Caroline, Fauvernier, Mathieu, Gerfaud-Valentin, Mathieu, Sève, Pascal, Jamilloux, Yvan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8509657/
https://www.ncbi.nlm.nih.gov/pubmed/34640563
http://dx.doi.org/10.3390/jcm10194544
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author Borciuch, Caroline
Fauvernier, Mathieu
Gerfaud-Valentin, Mathieu
Sève, Pascal
Jamilloux, Yvan
author_facet Borciuch, Caroline
Fauvernier, Mathieu
Gerfaud-Valentin, Mathieu
Sève, Pascal
Jamilloux, Yvan
author_sort Borciuch, Caroline
collection PubMed
description Still’s disease (SD) is often considered a benign disease, with low mortality rates. However, few studies have investigated SD mortality and its causes and most of these have been single-center cohort studies. We sought to examine mortality rates and causes of death among French decedents with SD. We performed a multiple-cause-of-death analysis on data collected between 1979 and 2016 by the French Epidemiological Center for the Medical Causes of Death. SD-related mortality rates were calculated and compared with the general population (observed/expected ratios, O/E). A total of 289 death certificates mentioned SD as the underlying cause of death (UCD) (n = 154) or as a non-underlying causes of death (NUCD) (n = 135). Over the study period, the mean age at death was 55.3 years (vs. 75.5 years in the general population), with differences depending on the period analyzed. The age-standardized mortality rate was 0.13/million person-years and was not different between men and women. When SD was the UCD, the most frequent associated causes were cardiovascular diseases (n = 29, 18.8%), infections (n = 25, 16.2%), and blood disorders (n = 11, 7.1%), including six cases (54%) with macrophage activation syndrome. As compared to the general population, SD decedents aged <45 years were more likely to die from a cardiovascular event (O/E = 3.41, p < 0.01); decedents at all ages were more likely to die from infection (O/E = 7.96–13.02, p < 0.001).
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spelling pubmed-85096572021-10-13 Still’s Disease Mortality Trends in France, 1979–2016: A Multiple-Cause-of-Death Study Borciuch, Caroline Fauvernier, Mathieu Gerfaud-Valentin, Mathieu Sève, Pascal Jamilloux, Yvan J Clin Med Article Still’s disease (SD) is often considered a benign disease, with low mortality rates. However, few studies have investigated SD mortality and its causes and most of these have been single-center cohort studies. We sought to examine mortality rates and causes of death among French decedents with SD. We performed a multiple-cause-of-death analysis on data collected between 1979 and 2016 by the French Epidemiological Center for the Medical Causes of Death. SD-related mortality rates were calculated and compared with the general population (observed/expected ratios, O/E). A total of 289 death certificates mentioned SD as the underlying cause of death (UCD) (n = 154) or as a non-underlying causes of death (NUCD) (n = 135). Over the study period, the mean age at death was 55.3 years (vs. 75.5 years in the general population), with differences depending on the period analyzed. The age-standardized mortality rate was 0.13/million person-years and was not different between men and women. When SD was the UCD, the most frequent associated causes were cardiovascular diseases (n = 29, 18.8%), infections (n = 25, 16.2%), and blood disorders (n = 11, 7.1%), including six cases (54%) with macrophage activation syndrome. As compared to the general population, SD decedents aged <45 years were more likely to die from a cardiovascular event (O/E = 3.41, p < 0.01); decedents at all ages were more likely to die from infection (O/E = 7.96–13.02, p < 0.001). MDPI 2021-09-30 /pmc/articles/PMC8509657/ /pubmed/34640563 http://dx.doi.org/10.3390/jcm10194544 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Borciuch, Caroline
Fauvernier, Mathieu
Gerfaud-Valentin, Mathieu
Sève, Pascal
Jamilloux, Yvan
Still’s Disease Mortality Trends in France, 1979–2016: A Multiple-Cause-of-Death Study
title Still’s Disease Mortality Trends in France, 1979–2016: A Multiple-Cause-of-Death Study
title_full Still’s Disease Mortality Trends in France, 1979–2016: A Multiple-Cause-of-Death Study
title_fullStr Still’s Disease Mortality Trends in France, 1979–2016: A Multiple-Cause-of-Death Study
title_full_unstemmed Still’s Disease Mortality Trends in France, 1979–2016: A Multiple-Cause-of-Death Study
title_short Still’s Disease Mortality Trends in France, 1979–2016: A Multiple-Cause-of-Death Study
title_sort still’s disease mortality trends in france, 1979–2016: a multiple-cause-of-death study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8509657/
https://www.ncbi.nlm.nih.gov/pubmed/34640563
http://dx.doi.org/10.3390/jcm10194544
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