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The Role of Complement Component C3 Activation in the Clinical Presentation and Prognosis of IgA Nephropathy—A National Study in Children
The aim of the study was to evaluate the influence of the intensity of mesangial C3 deposits in kidney biopsy and the serum C3 level on the clinical course and outcomes of IgAN in children. The study included 148 children from the Polish Pediatric IgAN Registry, diagnosed based on kidney biopsy. Pro...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8509710/ https://www.ncbi.nlm.nih.gov/pubmed/34640422 http://dx.doi.org/10.3390/jcm10194405 |
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| author | Mizerska-Wasiak, Małgorzata Such-Gruchot, Agnieszka Cichoń-Kawa, Karolina Turczyn, Agnieszka Małdyk, Jadwiga Miklaszewska, Monika Drożdż, Dorota Firszt-Adamczyk, Agnieszka Stankiewicz, Roman Rybi-Szumińska, Agnieszka Wasilewska, Anna Szczepańska, Maria Bieniaś, Beata Sikora, Przemysław Pukajło-Marczyk, Agnieszka Zwolińska, Danuta Pawlak-Bratkowska, Monika Tkaczyk, Marcin Zachwieja, Jacek Drożyńska-Duklas, Magdalena Żurowska, Aleksandra Gadomska-Prokop, Katarzyna Grenda, Ryszard Pańczyk-Tomaszewska, Małgorzata |
| author_facet | Mizerska-Wasiak, Małgorzata Such-Gruchot, Agnieszka Cichoń-Kawa, Karolina Turczyn, Agnieszka Małdyk, Jadwiga Miklaszewska, Monika Drożdż, Dorota Firszt-Adamczyk, Agnieszka Stankiewicz, Roman Rybi-Szumińska, Agnieszka Wasilewska, Anna Szczepańska, Maria Bieniaś, Beata Sikora, Przemysław Pukajło-Marczyk, Agnieszka Zwolińska, Danuta Pawlak-Bratkowska, Monika Tkaczyk, Marcin Zachwieja, Jacek Drożyńska-Duklas, Magdalena Żurowska, Aleksandra Gadomska-Prokop, Katarzyna Grenda, Ryszard Pańczyk-Tomaszewska, Małgorzata |
| author_sort | Mizerska-Wasiak, Małgorzata |
| collection | PubMed |
| description | The aim of the study was to evaluate the influence of the intensity of mesangial C3 deposits in kidney biopsy and the serum C3 level on the clinical course and outcomes of IgAN in children. The study included 148 children from the Polish Pediatric IgAN Registry, diagnosed based on kidney biopsy. Proteinuria, creatinine, IgA, C3 were evaluated twice in the study group, at baseline and the end of follow-up. Kidney biopsy was categorized using the Oxford classification, with a calculation of the MEST-C score. The intensity of IgA and C3 deposits were rated from 0 to +4 in immunofluorescence microscopy. The intensity of mesangial C3 > +1 deposits in kidney biopsy has an effect on renal survival with normal GFR in children with IgAN. A reduced serum C3 level has not been a prognostic factor in children but perhaps this finding should be confirmed in a larger group of children. |
| format | Online Article Text |
| id | pubmed-8509710 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2021 |
| publisher | MDPI |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-85097102021-10-13 The Role of Complement Component C3 Activation in the Clinical Presentation and Prognosis of IgA Nephropathy—A National Study in Children Mizerska-Wasiak, Małgorzata Such-Gruchot, Agnieszka Cichoń-Kawa, Karolina Turczyn, Agnieszka Małdyk, Jadwiga Miklaszewska, Monika Drożdż, Dorota Firszt-Adamczyk, Agnieszka Stankiewicz, Roman Rybi-Szumińska, Agnieszka Wasilewska, Anna Szczepańska, Maria Bieniaś, Beata Sikora, Przemysław Pukajło-Marczyk, Agnieszka Zwolińska, Danuta Pawlak-Bratkowska, Monika Tkaczyk, Marcin Zachwieja, Jacek Drożyńska-Duklas, Magdalena Żurowska, Aleksandra Gadomska-Prokop, Katarzyna Grenda, Ryszard Pańczyk-Tomaszewska, Małgorzata J Clin Med Article The aim of the study was to evaluate the influence of the intensity of mesangial C3 deposits in kidney biopsy and the serum C3 level on the clinical course and outcomes of IgAN in children. The study included 148 children from the Polish Pediatric IgAN Registry, diagnosed based on kidney biopsy. Proteinuria, creatinine, IgA, C3 were evaluated twice in the study group, at baseline and the end of follow-up. Kidney biopsy was categorized using the Oxford classification, with a calculation of the MEST-C score. The intensity of IgA and C3 deposits were rated from 0 to +4 in immunofluorescence microscopy. The intensity of mesangial C3 > +1 deposits in kidney biopsy has an effect on renal survival with normal GFR in children with IgAN. A reduced serum C3 level has not been a prognostic factor in children but perhaps this finding should be confirmed in a larger group of children. MDPI 2021-09-26 /pmc/articles/PMC8509710/ /pubmed/34640422 http://dx.doi.org/10.3390/jcm10194405 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
| spellingShingle | Article Mizerska-Wasiak, Małgorzata Such-Gruchot, Agnieszka Cichoń-Kawa, Karolina Turczyn, Agnieszka Małdyk, Jadwiga Miklaszewska, Monika Drożdż, Dorota Firszt-Adamczyk, Agnieszka Stankiewicz, Roman Rybi-Szumińska, Agnieszka Wasilewska, Anna Szczepańska, Maria Bieniaś, Beata Sikora, Przemysław Pukajło-Marczyk, Agnieszka Zwolińska, Danuta Pawlak-Bratkowska, Monika Tkaczyk, Marcin Zachwieja, Jacek Drożyńska-Duklas, Magdalena Żurowska, Aleksandra Gadomska-Prokop, Katarzyna Grenda, Ryszard Pańczyk-Tomaszewska, Małgorzata The Role of Complement Component C3 Activation in the Clinical Presentation and Prognosis of IgA Nephropathy—A National Study in Children |
| title | The Role of Complement Component C3 Activation in the Clinical Presentation and Prognosis of IgA Nephropathy—A National Study in Children |
| title_full | The Role of Complement Component C3 Activation in the Clinical Presentation and Prognosis of IgA Nephropathy—A National Study in Children |
| title_fullStr | The Role of Complement Component C3 Activation in the Clinical Presentation and Prognosis of IgA Nephropathy—A National Study in Children |
| title_full_unstemmed | The Role of Complement Component C3 Activation in the Clinical Presentation and Prognosis of IgA Nephropathy—A National Study in Children |
| title_short | The Role of Complement Component C3 Activation in the Clinical Presentation and Prognosis of IgA Nephropathy—A National Study in Children |
| title_sort | role of complement component c3 activation in the clinical presentation and prognosis of iga nephropathy—a national study in children |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8509710/ https://www.ncbi.nlm.nih.gov/pubmed/34640422 http://dx.doi.org/10.3390/jcm10194405 |
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