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Distinct Mechanisms Account for In Vitro Activation and Sensitization of TRPV1 by the Porphyrin Hemin

TRPV1 mediates pain occurring during sickling episodes in sickle cell disease (SCD). We examined if hemin, a porphyrin released during intravascular hemolysis modulates TRPV1. Calcium imaging and patch clamp were employed to examine effects of hemin on mouse dorsal root ganglion (DRG) neurons and HE...

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Detalles Bibliográficos
Autores principales:	Palmaers, Natalie E., Wiegand, Steffen B., Herzog, Christine, Echtermeyer, Frank G., Eberhardt, Mirjam J., Leffler, Andreas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8509749/ https://www.ncbi.nlm.nih.gov/pubmed/34639197 http://dx.doi.org/10.3390/ijms221910856

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