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Triglyceride and Small Dense LDL-Cholesterol in Patients with Acute Coronary Syndrome
Background: Small dense LDL-cholesterol is an established risk factor for atherosclerosis but is not routinely measured in daily practice. The association between small dense LDL-cholesterol and triglyceride, which in turn is routinely measured, in patients with acute coronary syndrome remains unkno...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8509760/ https://www.ncbi.nlm.nih.gov/pubmed/34640624 http://dx.doi.org/10.3390/jcm10194607 |
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author | Hori, Masakazu Imamura, Teruhiko Narang, Nikhil Onoda, Hiroshi Tanaka, Shuhei Ushijima, Ryuichi Sobajima, Mitsuo Fukuda, Nobuyuki Ueno, Hiroshi Kinugawa, Koichiro |
author_facet | Hori, Masakazu Imamura, Teruhiko Narang, Nikhil Onoda, Hiroshi Tanaka, Shuhei Ushijima, Ryuichi Sobajima, Mitsuo Fukuda, Nobuyuki Ueno, Hiroshi Kinugawa, Koichiro |
author_sort | Hori, Masakazu |
collection | PubMed |
description | Background: Small dense LDL-cholesterol is an established risk factor for atherosclerosis but is not routinely measured in daily practice. The association between small dense LDL-cholesterol and triglyceride, which in turn is routinely measured, in patients with acute coronary syndrome remains unknown. Methods: Consecutive patients with acute coronary syndrome who were admitted to our institute were prospectively included, and serum samples were obtained on admission. The association between small dense LDL-cholesterol and triglyceride was investigated. Results: Among 55 patients (median 71 years old, 64% men), median (interquartile range) small dense LDL-cholesterol was 23.6 (17.0, 36.0) and triglyceride was 101 (60, 134) mg/dL. Triglyceride level correlated with small dense LDL-cholesterol (r = 0.67, p < 0.001) and was an independent determinant of small dense LDL-cholesterol together with body mass index (p = 0.010 and p = 0.008, respectively). Those with high triglyceride and high body mass index had a 3-fold level of small dense LDL-cholesterol compared with those with low triglyceride and low body mass index (45.8 [35.0, 54.0] mg/dL versus 15.0 [11.6, 23.7] mg/dL, p = 0.001). Conclusions: Triglyceride level was a major determinant of small dense LDL-cholesterol in patients with acute coronary syndrome. Triglyceride level might be a useful and practical biomarker for risk stratification for patients with acute coronary syndrome together with body mass index. |
format | Online Article Text |
id | pubmed-8509760 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-85097602021-10-13 Triglyceride and Small Dense LDL-Cholesterol in Patients with Acute Coronary Syndrome Hori, Masakazu Imamura, Teruhiko Narang, Nikhil Onoda, Hiroshi Tanaka, Shuhei Ushijima, Ryuichi Sobajima, Mitsuo Fukuda, Nobuyuki Ueno, Hiroshi Kinugawa, Koichiro J Clin Med Article Background: Small dense LDL-cholesterol is an established risk factor for atherosclerosis but is not routinely measured in daily practice. The association between small dense LDL-cholesterol and triglyceride, which in turn is routinely measured, in patients with acute coronary syndrome remains unknown. Methods: Consecutive patients with acute coronary syndrome who were admitted to our institute were prospectively included, and serum samples were obtained on admission. The association between small dense LDL-cholesterol and triglyceride was investigated. Results: Among 55 patients (median 71 years old, 64% men), median (interquartile range) small dense LDL-cholesterol was 23.6 (17.0, 36.0) and triglyceride was 101 (60, 134) mg/dL. Triglyceride level correlated with small dense LDL-cholesterol (r = 0.67, p < 0.001) and was an independent determinant of small dense LDL-cholesterol together with body mass index (p = 0.010 and p = 0.008, respectively). Those with high triglyceride and high body mass index had a 3-fold level of small dense LDL-cholesterol compared with those with low triglyceride and low body mass index (45.8 [35.0, 54.0] mg/dL versus 15.0 [11.6, 23.7] mg/dL, p = 0.001). Conclusions: Triglyceride level was a major determinant of small dense LDL-cholesterol in patients with acute coronary syndrome. Triglyceride level might be a useful and practical biomarker for risk stratification for patients with acute coronary syndrome together with body mass index. MDPI 2021-10-08 /pmc/articles/PMC8509760/ /pubmed/34640624 http://dx.doi.org/10.3390/jcm10194607 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Hori, Masakazu Imamura, Teruhiko Narang, Nikhil Onoda, Hiroshi Tanaka, Shuhei Ushijima, Ryuichi Sobajima, Mitsuo Fukuda, Nobuyuki Ueno, Hiroshi Kinugawa, Koichiro Triglyceride and Small Dense LDL-Cholesterol in Patients with Acute Coronary Syndrome |
title | Triglyceride and Small Dense LDL-Cholesterol in Patients with Acute Coronary Syndrome |
title_full | Triglyceride and Small Dense LDL-Cholesterol in Patients with Acute Coronary Syndrome |
title_fullStr | Triglyceride and Small Dense LDL-Cholesterol in Patients with Acute Coronary Syndrome |
title_full_unstemmed | Triglyceride and Small Dense LDL-Cholesterol in Patients with Acute Coronary Syndrome |
title_short | Triglyceride and Small Dense LDL-Cholesterol in Patients with Acute Coronary Syndrome |
title_sort | triglyceride and small dense ldl-cholesterol in patients with acute coronary syndrome |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8509760/ https://www.ncbi.nlm.nih.gov/pubmed/34640624 http://dx.doi.org/10.3390/jcm10194607 |
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