Cargando…

Biomarker Value in the Diagnosis of Community-Acquired Pneumonia with Concomitant Chronic Heart Failure

The diagnosis of community-acquired pneumonia (CAP) with chronic heart failure (CHF) is associated with objective difficulties. Our case–control study aims to establish whether established serum inflammatory biomarkers are relevant to the diagnosis of CAP in patients with CHF. Seventy inpatients wit...

Descripción completa

Detalles Bibliográficos
Autores principales: Rachina, Svetlana, Bobylev, Andrey, Lazarev, Pavel, Mladov, Vladimir, Carrouel, Florence, Avdeev, Sergey, Kozlov, Roman, Bourgeois, Denis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8509775/
https://www.ncbi.nlm.nih.gov/pubmed/34640587
http://dx.doi.org/10.3390/jcm10194570
_version_ 1784582426107838464
author Rachina, Svetlana
Bobylev, Andrey
Lazarev, Pavel
Mladov, Vladimir
Carrouel, Florence
Avdeev, Sergey
Kozlov, Roman
Bourgeois, Denis
author_facet Rachina, Svetlana
Bobylev, Andrey
Lazarev, Pavel
Mladov, Vladimir
Carrouel, Florence
Avdeev, Sergey
Kozlov, Roman
Bourgeois, Denis
author_sort Rachina, Svetlana
collection PubMed
description The diagnosis of community-acquired pneumonia (CAP) with chronic heart failure (CHF) is associated with objective difficulties. Our case–control study aims to establish whether established serum inflammatory biomarkers are relevant to the diagnosis of CAP in patients with CHF. Seventy inpatients with previously diagnosed CHF and suspected non-severe CAP were recruited and then stratified into two subgroups with confirmed and rejected diagnosis of CAP. C-reactive protein (CRP), procalcitonin (PCT), tumor necrosis factor α (TNFα), interleukin-6 (IL-6) and brain natriuretic peptide (BNP) were measured. The value of biomarkers was determined using logistic regression, and their discriminatory efficacy was assessed by analyzing receiver operating characteristic (ROC) curves. Significantly higher levels of CRP 50.0 (35.5–98.5) mg/L, PCT 0.10 (0.05–0.54) ng/mL and IL-6 46.1(21.4–150.3) pg/mL in cases were identified as compared to the control group—15.0 (9.5–25.0) mg/L, 0.05 (0.05–0.05) ng/mL and 13.6 (9.5; 25.0) pg/mL, respectively. The Area Under the ROC Curve (95% CI) was the highest for CRP—0.91 (0.83–0.98), followed by PCT—0.81 (0.72–0.90) and IL-6—0.81 (0.71–0.91). A CRP value of >28.5 mg/L had an optimal sensitivity and specificity ratio (85.7/91.4%). In conclusion, the measurement of serum CRP, PCT and IL-6 levels can be useful for the diagnosis of CAP in patients with CHF. CRP showed optimal diagnostic utility in this population.
format Online
Article
Text
id pubmed-8509775
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-85097752021-10-13 Biomarker Value in the Diagnosis of Community-Acquired Pneumonia with Concomitant Chronic Heart Failure Rachina, Svetlana Bobylev, Andrey Lazarev, Pavel Mladov, Vladimir Carrouel, Florence Avdeev, Sergey Kozlov, Roman Bourgeois, Denis J Clin Med Article The diagnosis of community-acquired pneumonia (CAP) with chronic heart failure (CHF) is associated with objective difficulties. Our case–control study aims to establish whether established serum inflammatory biomarkers are relevant to the diagnosis of CAP in patients with CHF. Seventy inpatients with previously diagnosed CHF and suspected non-severe CAP were recruited and then stratified into two subgroups with confirmed and rejected diagnosis of CAP. C-reactive protein (CRP), procalcitonin (PCT), tumor necrosis factor α (TNFα), interleukin-6 (IL-6) and brain natriuretic peptide (BNP) were measured. The value of biomarkers was determined using logistic regression, and their discriminatory efficacy was assessed by analyzing receiver operating characteristic (ROC) curves. Significantly higher levels of CRP 50.0 (35.5–98.5) mg/L, PCT 0.10 (0.05–0.54) ng/mL and IL-6 46.1(21.4–150.3) pg/mL in cases were identified as compared to the control group—15.0 (9.5–25.0) mg/L, 0.05 (0.05–0.05) ng/mL and 13.6 (9.5; 25.0) pg/mL, respectively. The Area Under the ROC Curve (95% CI) was the highest for CRP—0.91 (0.83–0.98), followed by PCT—0.81 (0.72–0.90) and IL-6—0.81 (0.71–0.91). A CRP value of >28.5 mg/L had an optimal sensitivity and specificity ratio (85.7/91.4%). In conclusion, the measurement of serum CRP, PCT and IL-6 levels can be useful for the diagnosis of CAP in patients with CHF. CRP showed optimal diagnostic utility in this population. MDPI 2021-10-01 /pmc/articles/PMC8509775/ /pubmed/34640587 http://dx.doi.org/10.3390/jcm10194570 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Rachina, Svetlana
Bobylev, Andrey
Lazarev, Pavel
Mladov, Vladimir
Carrouel, Florence
Avdeev, Sergey
Kozlov, Roman
Bourgeois, Denis
Biomarker Value in the Diagnosis of Community-Acquired Pneumonia with Concomitant Chronic Heart Failure
title Biomarker Value in the Diagnosis of Community-Acquired Pneumonia with Concomitant Chronic Heart Failure
title_full Biomarker Value in the Diagnosis of Community-Acquired Pneumonia with Concomitant Chronic Heart Failure
title_fullStr Biomarker Value in the Diagnosis of Community-Acquired Pneumonia with Concomitant Chronic Heart Failure
title_full_unstemmed Biomarker Value in the Diagnosis of Community-Acquired Pneumonia with Concomitant Chronic Heart Failure
title_short Biomarker Value in the Diagnosis of Community-Acquired Pneumonia with Concomitant Chronic Heart Failure
title_sort biomarker value in the diagnosis of community-acquired pneumonia with concomitant chronic heart failure
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8509775/
https://www.ncbi.nlm.nih.gov/pubmed/34640587
http://dx.doi.org/10.3390/jcm10194570
work_keys_str_mv AT rachinasvetlana biomarkervalueinthediagnosisofcommunityacquiredpneumoniawithconcomitantchronicheartfailure
AT bobylevandrey biomarkervalueinthediagnosisofcommunityacquiredpneumoniawithconcomitantchronicheartfailure
AT lazarevpavel biomarkervalueinthediagnosisofcommunityacquiredpneumoniawithconcomitantchronicheartfailure
AT mladovvladimir biomarkervalueinthediagnosisofcommunityacquiredpneumoniawithconcomitantchronicheartfailure
AT carrouelflorence biomarkervalueinthediagnosisofcommunityacquiredpneumoniawithconcomitantchronicheartfailure
AT avdeevsergey biomarkervalueinthediagnosisofcommunityacquiredpneumoniawithconcomitantchronicheartfailure
AT kozlovroman biomarkervalueinthediagnosisofcommunityacquiredpneumoniawithconcomitantchronicheartfailure
AT bourgeoisdenis biomarkervalueinthediagnosisofcommunityacquiredpneumoniawithconcomitantchronicheartfailure