Cargando…

Radiological Evaluation of Cervical Spine Involvement in Rheumatoid Arthritis: A Cross-Sectional Retrospective Study

Background: Cervical spine lesions are a common manifestation of rheumatoid arthritis (RA). The purpose of this study was to conduct a retrospective analysis of radiological lesions in cervical spine in patients with RA and to correlate findings with clinical and laboratory parameters. Methods: Over...

Descripción completa

Detalles Bibliográficos
Autores principales: Kotecki, Mateusz, Gasik, Robert, Głuszko, Piotr, Sudoł-Szopińska, Iwona
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8509796/
https://www.ncbi.nlm.nih.gov/pubmed/34640605
http://dx.doi.org/10.3390/jcm10194587
_version_ 1784582431094865920
author Kotecki, Mateusz
Gasik, Robert
Głuszko, Piotr
Sudoł-Szopińska, Iwona
author_facet Kotecki, Mateusz
Gasik, Robert
Głuszko, Piotr
Sudoł-Szopińska, Iwona
author_sort Kotecki, Mateusz
collection PubMed
description Background: Cervical spine lesions are a common manifestation of rheumatoid arthritis (RA). The purpose of this study was to conduct a retrospective analysis of radiological lesions in cervical spine in patients with RA and to correlate findings with clinical and laboratory parameters. Methods: Overall, 240 consecutive patients with RA were referred for imaging by clinicians based on symptoms suggesting cervical spine involvement and/or long disease duration. In each patient, lateral radiographs and MRI of the cervical spine were performed. The imaging data were correlated with clinical records and laboratory data. Results: The cervical spine was affected in 179 patients (75%). The most common lesions were anterior atlanto-axial subluxation (AAS; 58%), subaxial subluxation (58%), and demineralization (48%). Cervical spine involvement was linked to longer disease duration (p = 0.007), the presence of rheumatoid factor (RF; p = 0.010), elevated C-reactive protein (CRP) levels (p = 0.016), and accelerated erythrocyte sedimentation rate (ESR; p = 0.025). Longer disease duration was associated with anterior AAS (p = 0.005), subaxial subluxation (p = 0.005), and basilar settling (p = 0.003). Conclusions: As many as 75% of RA patients develop lesions that can be observed on radiographs and through MRI. The most frequent radiological findings include anterior AAS and subaxial subluxation. Long disease duration, RF seropositivity, and elevated inflammatory markers were risk factors for cervical spine involvement.
format Online
Article
Text
id pubmed-8509796
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-85097962021-10-13 Radiological Evaluation of Cervical Spine Involvement in Rheumatoid Arthritis: A Cross-Sectional Retrospective Study Kotecki, Mateusz Gasik, Robert Głuszko, Piotr Sudoł-Szopińska, Iwona J Clin Med Article Background: Cervical spine lesions are a common manifestation of rheumatoid arthritis (RA). The purpose of this study was to conduct a retrospective analysis of radiological lesions in cervical spine in patients with RA and to correlate findings with clinical and laboratory parameters. Methods: Overall, 240 consecutive patients with RA were referred for imaging by clinicians based on symptoms suggesting cervical spine involvement and/or long disease duration. In each patient, lateral radiographs and MRI of the cervical spine were performed. The imaging data were correlated with clinical records and laboratory data. Results: The cervical spine was affected in 179 patients (75%). The most common lesions were anterior atlanto-axial subluxation (AAS; 58%), subaxial subluxation (58%), and demineralization (48%). Cervical spine involvement was linked to longer disease duration (p = 0.007), the presence of rheumatoid factor (RF; p = 0.010), elevated C-reactive protein (CRP) levels (p = 0.016), and accelerated erythrocyte sedimentation rate (ESR; p = 0.025). Longer disease duration was associated with anterior AAS (p = 0.005), subaxial subluxation (p = 0.005), and basilar settling (p = 0.003). Conclusions: As many as 75% of RA patients develop lesions that can be observed on radiographs and through MRI. The most frequent radiological findings include anterior AAS and subaxial subluxation. Long disease duration, RF seropositivity, and elevated inflammatory markers were risk factors for cervical spine involvement. MDPI 2021-10-05 /pmc/articles/PMC8509796/ /pubmed/34640605 http://dx.doi.org/10.3390/jcm10194587 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kotecki, Mateusz
Gasik, Robert
Głuszko, Piotr
Sudoł-Szopińska, Iwona
Radiological Evaluation of Cervical Spine Involvement in Rheumatoid Arthritis: A Cross-Sectional Retrospective Study
title Radiological Evaluation of Cervical Spine Involvement in Rheumatoid Arthritis: A Cross-Sectional Retrospective Study
title_full Radiological Evaluation of Cervical Spine Involvement in Rheumatoid Arthritis: A Cross-Sectional Retrospective Study
title_fullStr Radiological Evaluation of Cervical Spine Involvement in Rheumatoid Arthritis: A Cross-Sectional Retrospective Study
title_full_unstemmed Radiological Evaluation of Cervical Spine Involvement in Rheumatoid Arthritis: A Cross-Sectional Retrospective Study
title_short Radiological Evaluation of Cervical Spine Involvement in Rheumatoid Arthritis: A Cross-Sectional Retrospective Study
title_sort radiological evaluation of cervical spine involvement in rheumatoid arthritis: a cross-sectional retrospective study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8509796/
https://www.ncbi.nlm.nih.gov/pubmed/34640605
http://dx.doi.org/10.3390/jcm10194587
work_keys_str_mv AT koteckimateusz radiologicalevaluationofcervicalspineinvolvementinrheumatoidarthritisacrosssectionalretrospectivestudy
AT gasikrobert radiologicalevaluationofcervicalspineinvolvementinrheumatoidarthritisacrosssectionalretrospectivestudy
AT głuszkopiotr radiologicalevaluationofcervicalspineinvolvementinrheumatoidarthritisacrosssectionalretrospectivestudy
AT sudołszopinskaiwona radiologicalevaluationofcervicalspineinvolvementinrheumatoidarthritisacrosssectionalretrospectivestudy