Cargando…

Interaction of Thymine DNA Glycosylase with Oxidised 5-Methyl-cytosines in Their Amino- and Imino-Forms

Thymine DNA Glycosylase (TDG) is an enzyme of the base excision repair mechanism and removes damaged or mispaired bases from DNA via hydrolysis of the glycosidic bond. Specificity is of high importance for such a glycosylase, so as to avoid the damage of intact DNA. Among the substrates reported for...

Descripción completa

Detalles Bibliográficos
Autores principales:	Volkenandt, Senta, Beierlein, Frank, Imhof, Petra
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8510025/ https://www.ncbi.nlm.nih.gov/pubmed/34641273 http://dx.doi.org/10.3390/molecules26195728

Ejemplares similares

Measurement of deaminated cytosine adducts in DNA using a novel hybrid thymine DNA glycosylase
por: Hsu, Chia Wei, et al.
Publicado: (2022)

Thymine DNA glycosylase as a novel target for melanoma
por: Mancuso, Pietro, et al.
Publicado: (2019)

Thymine DNA glycosylase mediates chromatin phase separation in a DNA methylation–dependent manner
por: McGregor, Lauren A., et al.
Publicado: (2023)

Rapid excision of oxidized adenine by human thymine DNA glycosylase
por: Servius, Hardler W., et al.
Publicado: (2022)

Thymine DNA glycosylase specifically recognizes 5-carboxylcytosine-modified DNA
por: Zhang, Liang, et al.
Publicado: (2012)

Stoichiometry and affinity for thymine DNA glycosylase binding to specific and nonspecific DNA
por: Morgan, Michael T., et al.
Publicado: (2011)

The Role of Thymine DNA Glycosylase in Transcription, Active DNA Demethylation, and Cancer
por: Onabote, Oladapo, et al.
Publicado: (2022)

Association of Dnmt3a and thymine DNA glycosylase links DNA methylation with base-excision repair
por: Li, Ya-Qiang, et al.
Publicado: (2007)

Defining the impact of sumoylation on substrate binding and catalysis by thymine DNA glycosylase
por: Coey, Christopher T, et al.
Publicado: (2018)

Base Flip in DNA Studied by Molecular Dynamics Simulations of Differently-Oxidized Forms of Methyl-Cytosine
por: Helabad, Mahdi Bagherpoor, et al.
Publicado: (2014)

Thymine DNA glycosylase exhibits negligible affinity for nucleobases that it removes from DNA
por: Malik, Shuja S., et al.
Publicado: (2015)

Reversible chromatin condensation by the DNA repair and demethylation factor thymine DNA glycosylase
por: Deckard, Charles E, et al.
Publicado: (2021)

DNA methylation patterns of candidate genes regulated by thymine DNA glycosylase in patients with TP53 germline mutations
por: Fortes, F.P., et al.
Publicado: (2015)

Base Excision by Thymine DNA Glycosylase Mediates DNA-Directed Cytotoxicity of 5-Fluorouracil
por: Kunz, Christophe, et al.
Publicado: (2009)

Opposing regulatory roles of phosphorylation and acetylation in DNA mispair processing by thymine DNA glycosylase
por: Mohan, Ryan D., et al.
Publicado: (2010)

Dynamics of the excised base release in thymine DNA glycosylase during DNA repair process
por: Da, Lin-Tai, et al.
Publicado: (2018)

Lesion search and recognition by thymine DNA glycosylase revealed by single molecule imaging
por: Buechner, Claudia N., et al.
Publicado: (2015)

Effect of the thymine‐DNA glycosylase rs4135050 variant on Saudi smoker population
por: Almutairi, Mikhlid, et al.
Publicado: (2019)

Molecular Dynamics Simulations of a Chimeric Androgen Receptor Protein (SPARKI) Confirm the Importance of the Dimerization Domain on DNA Binding Specificity
por: Bagherpoor Helabad, Mahdi, et al.
Publicado: (2020)

A Germline Polymorphism of Thymine DNA Glycosylase Induces Genomic Instability and Cellular Transformation
por: Sjolund, Ashley, et al.
Publicado: (2014)

Thymine DNA Glycosylase (TDG) is involved in the pathogenesis of intestinal tumors with reduced APC expression
por: Xu, Jinfei, et al.
Publicado: (2017)

Protonation-State Dependence of Hydration and Interactions in the Two Proton-Conducting Channels of Cytochrome c Oxidase
por: Gorriz, Rene F., et al.
Publicado: (2023)

Structural basis of damage recognition by thymine DNA glycosylase: Key roles for N-terminal residues
por: Coey, Christopher T., et al.
Publicado: (2016)

Oestrogen receptor β regulates epigenetic patterns at specific genomic loci through interaction with thymine DNA glycosylase
por: Liu, Yun, et al.
Publicado: (2016)

A Mutant of Uracil DNA Glycosylase That Distinguishes between Cytosine and 5-Methylcytosine
por: Kimber, Scott T., et al.
Publicado: (2014)

Biochemical and structural characterization of the glycosylase domain of MBD4 bound to thymine and 5-hydroxymethyuracil-containing DNA
por: Moréra, Solange, et al.
Publicado: (2012)

The Hepatitis B Virus X Protein Inhibits Thymine DNA Glycosylase Initiated Base Excision Repair
por: van de Klundert, Maarten A. A., et al.
Publicado: (2012)

Thymine DNA glycosylase recognizes the geometry alteration of minor grooves induced by 5-formylcytosine and 5-carboxylcytosine
por: Fu, Tianran, et al.
Publicado: (2019)

DNA sequence homology induces cytosine-to-thymine mutation by a heterochromatin-related pathway in Neurospora
por: Gladyshev, Eugene, et al.
Publicado: (2017)

Excision of thymine and 5-hydroxymethyluracil by the MBD4 DNA glycosylase domain: structural basis and implications for active DNA demethylation
por: Hashimoto, Hideharu, et al.
Publicado: (2012)

SUMO-1 regulates the conformational dynamics of Thymine-DNA Glycosylase regulatory domain and competes with its DNA binding activity
por: Smet-Nocca, Caroline, et al.
Publicado: (2011)

Base-flipping dynamics from an intrahelical to an extrahelical state exerted by thymine DNA glycosylase during DNA repair process
por: Da, Lin-Tai, et al.
Publicado: (2018)

Atomic resolution of short-range sliding dynamics of thymine DNA glycosylase along DNA minor-groove for lesion recognition
por: Tian, Jiaqi, et al.
Publicado: (2021)

Genome-wide distribution of 5-formylcytosine in embryonic stem cells is associated with transcription and depends on thymine DNA glycosylase
por: Raiber, Eun-Ang, et al.
Publicado: (2012)

Surface-Enhanced Hyper-Raman Spectra of Adenine, Guanine, Cytosine, Thymine, and Uracil
por: Madzharova, Fani, et al.
Publicado: (2016)

Excision of 5-hydroxymethyluracil and 5-carboxylcytosine by the thymine DNA glycosylase domain: its structural basis and implications for active DNA demethylation
por: Hashimoto, Hideharu, et al.
Publicado: (2012)

Thymine DNA glycosylase‐regulated TAZ promotes radioresistance by targeting nonhomologous end joining and tumor progression in esophageal cancer
por: Zhou, Wei, et al.
Publicado: (2020)

Graphene Oxide Nanoribbons in Chitosan for Simultaneous Electrochemical Detection of Guanine, Adenine, Thymine and Cytosine
por: Zhou, Jiayun, et al.
Publicado: (2020)

Direct alkylation of calf thymus DNA by acrylonitrile. Isolation of cyanoethyl adducts of guanine and thymine and carboxyethyl adducts of adenine and cytosine.
por: Solomon, J J, et al.
Publicado: (1985)

Chimeric d/l-DNA Probes of Base Excision Repair Enable Real-Time Monitoring of Thymine DNA Glycosylase Activity in Live Cells
por: Zhong, Wenrui, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_llo8b2l26mkvmj7meaj3v79d6i