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CRISPR/Cas9-Induced Mutagenesis Corroborates the Role of Transportin-SR2 in HIV-1 Nuclear Import

To infect nondividing cells, HIV-1 needs to cross the nuclear membrane. The importin transportin-SR2 (TRN-SR2 or transportin-3) has been proposed to mediate HIV-1 nuclear import, but the detailed mechanism remains unresolved. The direct interaction of TRN-SR2 with HIV-1 integrase (IN) has been propo...

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Detalles Bibliográficos
Autores principales:	Janssens, Julie, Blokken, Jolien, Lampi, Yulia, De Wit, Flore, Zurnic Bonisch, Irena, Nombela, Ivan, Van de Velde, Paulien, Van Remoortel, Barbara, Gijsbers, Rik, Christ, Frauke, Debyser, Zeger
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8510174/ https://www.ncbi.nlm.nih.gov/pubmed/34612665 http://dx.doi.org/10.1128/Spectrum.01336-21

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