In Vitro Activity of Omadacycline and Five Comparators against Contemporary Ribotypes of Clostridioides difficile in Stockholm, Sweden

Clostridioides difficile infection represents a growing clinical challenge. The new compound omadacycline is a potential treatment alternative, as many antibiotics have limited activity or are rarely used due to costs and side effects. The activity of omadacycline and five comparators was assessed w...

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Autores principales: Camporeale, Angela, Tellapragada, Chaitanya, Kornijenko, Jelena, Nord, Carl Erik, Giske, Christian G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2021
Materias:
Observation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8510182/
https://www.ncbi.nlm.nih.gov/pubmed/34612686
http://dx.doi.org/10.1128/Spectrum.01440-21
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author Camporeale, Angela
Tellapragada, Chaitanya
Kornijenko, Jelena
Nord, Carl Erik
Giske, Christian G.
author_facet Camporeale, Angela
Tellapragada, Chaitanya
Kornijenko, Jelena
Nord, Carl Erik
Giske, Christian G.
author_sort Camporeale, Angela
collection PubMed
description Clostridioides difficile infection represents a growing clinical challenge. The new compound omadacycline is a potential treatment alternative, as many antibiotics have limited activity or are rarely used due to costs and side effects. The activity of omadacycline and five comparators was assessed with agar dilution on a 2015-to-2018 collection of 65 C. difficile isolates from Sweden. Omadacycline demonstrated in vitro activity against the contemporary ribotypes of C. difficile, and further clinical investigation is needed. IMPORTANCE Evaluating the activity of novel antimicrobials like omadacycline is of great interest, as a reliable and efficient antimicrobial treatment for Clostridioides difficile infections is in demand.
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spelling pubmed-85101822021-11-08 In Vitro Activity of Omadacycline and Five Comparators against Contemporary Ribotypes of Clostridioides difficile in Stockholm, Sweden Camporeale, Angela Tellapragada, Chaitanya Kornijenko, Jelena Nord, Carl Erik Giske, Christian G. Microbiol Spectr Observation Clostridioides difficile infection represents a growing clinical challenge. The new compound omadacycline is a potential treatment alternative, as many antibiotics have limited activity or are rarely used due to costs and side effects. The activity of omadacycline and five comparators was assessed with agar dilution on a 2015-to-2018 collection of 65 C. difficile isolates from Sweden. Omadacycline demonstrated in vitro activity against the contemporary ribotypes of C. difficile, and further clinical investigation is needed. IMPORTANCE Evaluating the activity of novel antimicrobials like omadacycline is of great interest, as a reliable and efficient antimicrobial treatment for Clostridioides difficile infections is in demand. American Society for Microbiology 2021-10-06 /pmc/articles/PMC8510182/ /pubmed/34612686 http://dx.doi.org/10.1128/Spectrum.01440-21 Text en Copyright © 2021 Camporeale et al. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Observation
Camporeale, Angela
Tellapragada, Chaitanya
Kornijenko, Jelena
Nord, Carl Erik
Giske, Christian G.
In Vitro Activity of Omadacycline and Five Comparators against Contemporary Ribotypes of Clostridioides difficile in Stockholm, Sweden
title In Vitro Activity of Omadacycline and Five Comparators against Contemporary Ribotypes of Clostridioides difficile in Stockholm, Sweden
title_full In Vitro Activity of Omadacycline and Five Comparators against Contemporary Ribotypes of Clostridioides difficile in Stockholm, Sweden
title_fullStr In Vitro Activity of Omadacycline and Five Comparators against Contemporary Ribotypes of Clostridioides difficile in Stockholm, Sweden
title_full_unstemmed In Vitro Activity of Omadacycline and Five Comparators against Contemporary Ribotypes of Clostridioides difficile in Stockholm, Sweden
title_short In Vitro Activity of Omadacycline and Five Comparators against Contemporary Ribotypes of Clostridioides difficile in Stockholm, Sweden
title_sort in vitro activity of omadacycline and five comparators against contemporary ribotypes of clostridioides difficile in stockholm, sweden
topic Observation
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8510182/
https://www.ncbi.nlm.nih.gov/pubmed/34612686
http://dx.doi.org/10.1128/Spectrum.01440-21
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