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Physicochemical Characteristics of Chitosan-Based Hydrogels Containing Albumin Particles and Aloe vera Juice as Transdermal Systems Functionalized in the Viewpoint of Potential Biomedical Applications

In recent years, many investigations on the development of innovative dressing materials with potential applications, e.g., for cytostatics delivery, have been performed. One of the most promising carriers is albumin, which tends to accumulate near cancer cells. Here, chitosan-based hydrogels contai...

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Autores principales: Kudłacik-Kramarczyk, Sonia, Głąb, Magdalena, Drabczyk, Anna, Kordyka, Aleksandra, Godzierz, Marcin, Wróbel, Paweł S., Krzan, Marcel, Uthayakumar, Marimuthu, Kędzierska, Magdalena, Tyliszczak, Bożena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8510356/
https://www.ncbi.nlm.nih.gov/pubmed/34640229
http://dx.doi.org/10.3390/ma14195832
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author Kudłacik-Kramarczyk, Sonia
Głąb, Magdalena
Drabczyk, Anna
Kordyka, Aleksandra
Godzierz, Marcin
Wróbel, Paweł S.
Krzan, Marcel
Uthayakumar, Marimuthu
Kędzierska, Magdalena
Tyliszczak, Bożena
author_facet Kudłacik-Kramarczyk, Sonia
Głąb, Magdalena
Drabczyk, Anna
Kordyka, Aleksandra
Godzierz, Marcin
Wróbel, Paweł S.
Krzan, Marcel
Uthayakumar, Marimuthu
Kędzierska, Magdalena
Tyliszczak, Bożena
author_sort Kudłacik-Kramarczyk, Sonia
collection PubMed
description In recent years, many investigations on the development of innovative dressing materials with potential applications, e.g., for cytostatics delivery, have been performed. One of the most promising carriers is albumin, which tends to accumulate near cancer cells. Here, chitosan-based hydrogels containing albumin spheres and Aloe vera juice, designed for the treatment of skin cancers or burn wounds resulting from radiotherapy, were developed. The presence of albumin in hydrogel matrices was confirmed via Fourier transform infrared (FT-IR) and Raman spectroscopy. Albumin spheres were clearly visible in microscopic images. It was proved that the introduction of albumin into hydrogels resulted in their increased resistance to the tensile load, i.e., approximately 30% more force was needed to break such materials. Modified hydrogels showed approximately 10% more swelling ability. All hydrogels were characterized by hydrophilicity (contact angles were <90°) which may support the regeneration of epithelial cells and non-cytotoxicity towards murine fibroblasts L929 and released Aloe vera juice more effectively in an acidic environment than in a neutral one wherein spheres introduced into the hydrogel matrix extended the release time. Thus, the developed materials, due to their chemical composition and physicochemical properties, constitute promising materials with great application potential for biomedical purposes.
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spelling pubmed-85103562021-10-13 Physicochemical Characteristics of Chitosan-Based Hydrogels Containing Albumin Particles and Aloe vera Juice as Transdermal Systems Functionalized in the Viewpoint of Potential Biomedical Applications Kudłacik-Kramarczyk, Sonia Głąb, Magdalena Drabczyk, Anna Kordyka, Aleksandra Godzierz, Marcin Wróbel, Paweł S. Krzan, Marcel Uthayakumar, Marimuthu Kędzierska, Magdalena Tyliszczak, Bożena Materials (Basel) Article In recent years, many investigations on the development of innovative dressing materials with potential applications, e.g., for cytostatics delivery, have been performed. One of the most promising carriers is albumin, which tends to accumulate near cancer cells. Here, chitosan-based hydrogels containing albumin spheres and Aloe vera juice, designed for the treatment of skin cancers or burn wounds resulting from radiotherapy, were developed. The presence of albumin in hydrogel matrices was confirmed via Fourier transform infrared (FT-IR) and Raman spectroscopy. Albumin spheres were clearly visible in microscopic images. It was proved that the introduction of albumin into hydrogels resulted in their increased resistance to the tensile load, i.e., approximately 30% more force was needed to break such materials. Modified hydrogels showed approximately 10% more swelling ability. All hydrogels were characterized by hydrophilicity (contact angles were <90°) which may support the regeneration of epithelial cells and non-cytotoxicity towards murine fibroblasts L929 and released Aloe vera juice more effectively in an acidic environment than in a neutral one wherein spheres introduced into the hydrogel matrix extended the release time. Thus, the developed materials, due to their chemical composition and physicochemical properties, constitute promising materials with great application potential for biomedical purposes. MDPI 2021-10-06 /pmc/articles/PMC8510356/ /pubmed/34640229 http://dx.doi.org/10.3390/ma14195832 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kudłacik-Kramarczyk, Sonia
Głąb, Magdalena
Drabczyk, Anna
Kordyka, Aleksandra
Godzierz, Marcin
Wróbel, Paweł S.
Krzan, Marcel
Uthayakumar, Marimuthu
Kędzierska, Magdalena
Tyliszczak, Bożena
Physicochemical Characteristics of Chitosan-Based Hydrogels Containing Albumin Particles and Aloe vera Juice as Transdermal Systems Functionalized in the Viewpoint of Potential Biomedical Applications
title Physicochemical Characteristics of Chitosan-Based Hydrogels Containing Albumin Particles and Aloe vera Juice as Transdermal Systems Functionalized in the Viewpoint of Potential Biomedical Applications
title_full Physicochemical Characteristics of Chitosan-Based Hydrogels Containing Albumin Particles and Aloe vera Juice as Transdermal Systems Functionalized in the Viewpoint of Potential Biomedical Applications
title_fullStr Physicochemical Characteristics of Chitosan-Based Hydrogels Containing Albumin Particles and Aloe vera Juice as Transdermal Systems Functionalized in the Viewpoint of Potential Biomedical Applications
title_full_unstemmed Physicochemical Characteristics of Chitosan-Based Hydrogels Containing Albumin Particles and Aloe vera Juice as Transdermal Systems Functionalized in the Viewpoint of Potential Biomedical Applications
title_short Physicochemical Characteristics of Chitosan-Based Hydrogels Containing Albumin Particles and Aloe vera Juice as Transdermal Systems Functionalized in the Viewpoint of Potential Biomedical Applications
title_sort physicochemical characteristics of chitosan-based hydrogels containing albumin particles and aloe vera juice as transdermal systems functionalized in the viewpoint of potential biomedical applications
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8510356/
https://www.ncbi.nlm.nih.gov/pubmed/34640229
http://dx.doi.org/10.3390/ma14195832
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