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Revisiting an IgG Fc Loss-of-Function Experiment: the Role of Complement in HIV Broadly Neutralizing Antibody b12 Activity

The role of the complement system in HIV-1 immunity and pathogenesis is multifaceted, and an improved understanding of complement activities mediated by HIV-1-specific antibodies has the potential to inform and advance clinical development efforts. A seminal nonhuman primate challenge experiment sug...

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Detalles Bibliográficos
Autores principales:	Goldberg, Benjamin S., Kaku, Chengzi I., Dufloo, Jérémy, Bruel, Timothée, Schwartz, Olivier, Spencer, David A., Hessell, Ann J., Ackerman, Margaret E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8510540/ https://www.ncbi.nlm.nih.gov/pubmed/34634936 http://dx.doi.org/10.1128/mBio.01743-21

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