Cargando…

Revisiting an IgG Fc Loss-of-Function Experiment: the Role of Complement in HIV Broadly Neutralizing Antibody b12 Activity

The role of the complement system in HIV-1 immunity and pathogenesis is multifaceted, and an improved understanding of complement activities mediated by HIV-1-specific antibodies has the potential to inform and advance clinical development efforts. A seminal nonhuman primate challenge experiment sug...

Descripción completa

Detalles Bibliográficos
Autores principales:	Goldberg, Benjamin S., Kaku, Chengzi I., Dufloo, Jérémy, Bruel, Timothée, Schwartz, Olivier, Spencer, David A., Hessell, Ann J., Ackerman, Margaret E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8510540/ https://www.ncbi.nlm.nih.gov/pubmed/34634936 http://dx.doi.org/10.1128/mBio.01743-21

Ejemplares similares

Sex and species associated differences in Complement-mediated immunity in Humans and Rhesus macaques
por: Kelkar, Natasha S., et al.
Publicado: (2023)

HIV-1 cell-to-cell transmission and broadly neutralizing antibodies
por: Dufloo, Jérémy, et al.
Publicado: (2018)

Complement contributes to antibody-mediated protection against repeated SHIV challenge
por: Goldberg, Benjamin S., et al.
Publicado: (2023)

Phagocytosis by an HIV antibody is associated with reduced viremia irrespective of enhanced complement lysis
por: Spencer, David A., et al.
Publicado: (2022)

IgG3 enhances neutralization potency and Fc effector function of an HIV V2-specific broadly neutralizing antibody
por: Richardson, Simone I., et al.
Publicado: (2019)

HIV Broadly Neutralizing Antibodies Expressed as IgG3 Preserve Neutralization Potency and Show Improved Fc Effector Function
por: Richardson, Simone I., et al.
Publicado: (2021)

Evidence for the Role of a Second Fc-Binding Receptor in Placental IgG Transfer in Nonhuman Primates
por: Rosenberg, Yvonne J., et al.
Publicado: (2023)

The role of Fc–FcγR interactions in IgG-mediated microbial neutralization
por: Bournazos, Stylianos, et al.
Publicado: (2015)

Potent human broadly SARS-CoV-2–neutralizing IgA and IgG antibodies effective against Omicron BA.1 and BA.2
por: Planchais, Cyril, et al.
Publicado: (2022)

Broadly neutralizing anti-HIV-1 antibodies tether viral particles at the surface of infected cells
por: Dufloo, Jérémy, et al.
Publicado: (2022)

Conformational Plasticity in Broadly Neutralizing HIV-1 Antibodies Triggers Polyreactivity
por: Prigent, Julie, et al.
Publicado: (2018)

Evidence of variable human Fcγ receptor-Fc affinities across differentially-complexed IgG
por: Crowley, Andrew R., et al.
Publicado: (2023)

Therapeutic Administration of Broadly Neutralizing FI6 Antibody Reveals Lack of Interaction Between Human IgG1 and Pig Fc Receptors
por: Morgan, Sophie B., et al.
Publicado: (2018)

Structural Basis for Broad HIV-1 Neutralization by the MPER-Specific Human Broadly Neutralizing Antibody LN01
por: Pinto, Dora, et al.
Publicado: (2019)

Staphylococcus pseudintermedius Sbi paralogs inhibit complement and bind IgM, IgG Fc and Fab
por: Sewid, Alaa H., et al.
Publicado: (2019)

Potential of Murine IgG1 and Human IgG4 to Inhibit the Classical Complement and Fcγ Receptor Activation Pathways
por: Lilienthal, Gina-Maria, et al.
Publicado: (2018)

Noncanonical placental Fc receptors: What is their role in modulating transplacental transfer of maternal IgG?
por: Martinez, David R., et al.
Publicado: (2018)

Advancing HIV Broadly Neutralizing Antibodies: From Discovery to the Clinic
por: Spencer, David A., et al.
Publicado: (2021)

Fc-Mediated Functions of Porcine IgG Subclasses
por: Paudyal, Basudev, et al.
Publicado: (2022)

Biophysical Evaluation of Rhesus Macaque Fc Gamma Receptors Reveals Similar IgG Fc Glycoform Preferences to Human Receptors
por: Crowley, Andrew R., et al.
Publicado: (2021)

Fc galactosylation of anti-platelet human IgG1 alloantibodies enhances complement activation on platelets
por: van Osch, Thijs L.J., et al.
Publicado: (2022)

HIV-specific Fc effector function early in infection predicts the development of broadly neutralizing antibodies
por: Richardson, Simone I., et al.
Publicado: (2018)

Epitope convergence of broadly HIV-1 neutralizing IgA and IgG antibody lineages in a viremic controller
por: Lorin, Valérie, et al.
Publicado: (2022)

IgG Suppresses Antibody Responses in Mice Lacking C1q, C3, Complement Receptors 1 and 2, or IgG Fc-Receptors
por: Bergström, Joakim J. E., et al.
Publicado: (2015)

Systemic administration of a broadly-neutralizing IgG antibody to generate HIV-neutralization responses in breast milk
por: Fouda, GG, et al.
Publicado: (2012)

A cluster of broadly neutralizing IgG against BK polyomavirus in a repertoire dominated by IgM
por: Nguyen, Ngoc-Khanh, et al.
Publicado: (2023)

Specificity of fc receptors for IgG2a, IgG1/IgG2b, and IgE on rat macrophages
Publicado: (1981)

B-lymphocytes activation by the Fc region of IgG
Publicado: (1977)

VSV-Displayed HIV-1 Envelope Identifies Broadly Neutralizing Antibodies Class-Switched to IgG and IgA
por: Jia, Manxue, et al.
Publicado: (2020)

Human IgG/FcγR Interactions Are Modulated by Streptococcal IgG Glycan Hydrolysis
por: Allhorn, Maria, et al.
Publicado: (2008)

IgG Fc-binding motif-conjugated HIV-1 fusion inhibitor exhibits improved potency and in vivo half-life: Potential application in combination with broad neutralizing antibodies
por: Bi, Wenwen, et al.
Publicado: (2019)

IgG4 antibodies from patients with asymptomatic bancroftian filariasis inhibit the binding of IgG1 and IgG2 to C1q in a Fc-Fc-dependent mechanism
por: Prodjinotho, Ulrich F., et al.
Publicado: (2019)

Biodistribution of neutralizing monoclonal antibodies IgG1 b12 and LALA in mucosal and lymphatic tissues of rhesus macaques
por: Hessell, AJ, et al.
Publicado: (2012)

Elimination of HIV-1-infected cells by broadly neutralizing antibodies
por: Bruel, Timothée, et al.
Publicado: (2016)

Pharmacokinetic Models for FcRn-Mediated IgG Disposition
por: Xiao, Jim J.
Publicado: (2012)

IgG-Fc glycoengineering in non-mammalian expression hosts
por: Loos, Andreas, et al.
Publicado: (2012)

Crystal structure of deglycosylated human IgG4-Fc
por: Davies, Anna M., et al.
Publicado: (2014)

Generation and Characterization of an IgG4 Monomeric Fc Platform
por: Shan, Lu, et al.
Publicado: (2016)

IgG Fc engineering to modulate antibody effector functions
por: Wang, Xinhua, et al.
Publicado: (2017)

IgG and Fcγ Receptors in Intestinal Immunity and Inflammation
por: Castro-Dopico, Tomas, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_j274tf0loh7a36j3pg34vgvukt