Preparation and in vivo/in vitro characterization of Ticagrelor PLGA sustained-release microspheres for injection

The objective of this paper was to develop a PLGA carrier Ticagrelor sustained-release microspheres preparation, which was expected to continue to release Ticagrelor for 14 days with a high encapsulation rate. Ticagrelor microspheres were prepared successfully with average diameter of 7.31 µm, drug...

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Autores principales: Hao, Linkun, Jiang, Yunying, Zhang, Ru, Zhang, Ningning, Yang, Yang, Gao, Ying, Song, Yimin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Full Length Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8510617/
https://www.ncbi.nlm.nih.gov/pubmed/34650328
http://dx.doi.org/10.1080/15685551.2021.1984008
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author Hao, Linkun
Jiang, Yunying
Zhang, Ru
Zhang, Ningning
Yang, Yang
Gao, Ying
Song, Yimin
author_facet Hao, Linkun
Jiang, Yunying
Zhang, Ru
Zhang, Ningning
Yang, Yang
Gao, Ying
Song, Yimin
author_sort Hao, Linkun
collection PubMed
description The objective of this paper was to develop a PLGA carrier Ticagrelor sustained-release microspheres preparation, which was expected to continue to release Ticagrelor for 14 days with a high encapsulation rate. Ticagrelor microspheres were prepared successfully with average diameter of 7.31 µm, drug loading of 12.49 ± 0.32% and EE up to 79.09 ± 1.69%. In the release medium of PH7.4 PBS, the microspheres showed good drug release behavior in vitro. In vivo release results also showed that the sustained-release microspheres could effectively control drug release in vivo and maintain a relatively stable blood drug concentration for about 2 weeks. The results indicate that Ticagrelor sustained-release microspheres can be used for long-term treatment of acute coronary syndrome.
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spelling pubmed-85106172021-10-13 Preparation and in vivo/in vitro characterization of Ticagrelor PLGA sustained-release microspheres for injection Hao, Linkun Jiang, Yunying Zhang, Ru Zhang, Ningning Yang, Yang Gao, Ying Song, Yimin Des Monomers Polym Full Length Article The objective of this paper was to develop a PLGA carrier Ticagrelor sustained-release microspheres preparation, which was expected to continue to release Ticagrelor for 14 days with a high encapsulation rate. Ticagrelor microspheres were prepared successfully with average diameter of 7.31 µm, drug loading of 12.49 ± 0.32% and EE up to 79.09 ± 1.69%. In the release medium of PH7.4 PBS, the microspheres showed good drug release behavior in vitro. In vivo release results also showed that the sustained-release microspheres could effectively control drug release in vivo and maintain a relatively stable blood drug concentration for about 2 weeks. The results indicate that Ticagrelor sustained-release microspheres can be used for long-term treatment of acute coronary syndrome. Taylor & Francis 2021-10-08 /pmc/articles/PMC8510617/ /pubmed/34650328 http://dx.doi.org/10.1080/15685551.2021.1984008 Text en © 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Full Length Article
Hao, Linkun
Jiang, Yunying
Zhang, Ru
Zhang, Ningning
Yang, Yang
Gao, Ying
Song, Yimin
Preparation and in vivo/in vitro characterization of Ticagrelor PLGA sustained-release microspheres for injection
title Preparation and in vivo/in vitro characterization of Ticagrelor PLGA sustained-release microspheres for injection
title_full Preparation and in vivo/in vitro characterization of Ticagrelor PLGA sustained-release microspheres for injection
title_fullStr Preparation and in vivo/in vitro characterization of Ticagrelor PLGA sustained-release microspheres for injection
title_full_unstemmed Preparation and in vivo/in vitro characterization of Ticagrelor PLGA sustained-release microspheres for injection
title_short Preparation and in vivo/in vitro characterization of Ticagrelor PLGA sustained-release microspheres for injection
title_sort preparation and in vivo/in vitro characterization of ticagrelor plga sustained-release microspheres for injection
topic Full Length Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8510617/
https://www.ncbi.nlm.nih.gov/pubmed/34650328
http://dx.doi.org/10.1080/15685551.2021.1984008
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