Height, but not binding epitope, affects the potency of synthetic TCR agonists

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Under physiological conditions, peptide-major histocompatibility complex (pMHC) molecules can trigger T cell receptors (TCRs) as monovalent ligands that are sparsely distributed on the plasma membrane of an antigen-presenting cell. TCRs can also be triggered by artificial clustering, such as with pM...

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Detalles Bibliográficos
Autores principales: Wilhelm, Kiera B., Morita, Shumpei, McAffee, Darren B., Kim, Sungi, O’Dair, Mark K., Groves, Jay T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Biophysical Society 2021
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8511163/
https://www.ncbi.nlm.nih.gov/pubmed/34453921
http://dx.doi.org/10.1016/j.bpj.2021.08.027

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