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Dosimetry and radioprotection evaluations of very high energy electron beams

Very high energy electrons (VHEEs) represent a promising alternative for the treatment of deep-seated tumors over conventional radiotherapy (RT), owing to their favourable dosimetric characteristics. Given the high energy of the electrons, one of the concerns has been the production of photoneutrons...

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Autores principales: Masilela, Thongchai A. M., Delorme, Rachel, Prezado, Yolanda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8511248/
https://www.ncbi.nlm.nih.gov/pubmed/34642417
http://dx.doi.org/10.1038/s41598-021-99645-7
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author Masilela, Thongchai A. M.
Delorme, Rachel
Prezado, Yolanda
author_facet Masilela, Thongchai A. M.
Delorme, Rachel
Prezado, Yolanda
author_sort Masilela, Thongchai A. M.
collection PubMed
description Very high energy electrons (VHEEs) represent a promising alternative for the treatment of deep-seated tumors over conventional radiotherapy (RT), owing to their favourable dosimetric characteristics. Given the high energy of the electrons, one of the concerns has been the production of photoneutrons. In this article we explore the consequence, in terms of neutron yield in a water phantom, of using a typical electron applicator in conjunction with a 2 GeV and 200 MeV VHEE beam. Additionally, we evaluate the resulting ambient neutron dose equivalent at various locations between the phantom and a concrete wall. Through Monte Carlo (MC) simulations it was found that an applicator acts to reduce the depth of the dose build-up region, giving rise to lower exit doses but higher entrance doses. Furthermore, neutrons are injected into the entrance region of the phantom. The highest dose equivalent found was approximately 1.7 mSv/Gy in the vicinity of the concrete wall. Nevertheless, we concluded that configurations of VHEEs studied in this article are similar to conventional proton therapy treatments in terms of their neutron yield and ambient dose equivalent. Therefore, a clinical implementation of VHEEs would likely not warrant additional radioprotection safeguards compared to conventional RT treatments.
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spelling pubmed-85112482021-10-14 Dosimetry and radioprotection evaluations of very high energy electron beams Masilela, Thongchai A. M. Delorme, Rachel Prezado, Yolanda Sci Rep Article Very high energy electrons (VHEEs) represent a promising alternative for the treatment of deep-seated tumors over conventional radiotherapy (RT), owing to their favourable dosimetric characteristics. Given the high energy of the electrons, one of the concerns has been the production of photoneutrons. In this article we explore the consequence, in terms of neutron yield in a water phantom, of using a typical electron applicator in conjunction with a 2 GeV and 200 MeV VHEE beam. Additionally, we evaluate the resulting ambient neutron dose equivalent at various locations between the phantom and a concrete wall. Through Monte Carlo (MC) simulations it was found that an applicator acts to reduce the depth of the dose build-up region, giving rise to lower exit doses but higher entrance doses. Furthermore, neutrons are injected into the entrance region of the phantom. The highest dose equivalent found was approximately 1.7 mSv/Gy in the vicinity of the concrete wall. Nevertheless, we concluded that configurations of VHEEs studied in this article are similar to conventional proton therapy treatments in terms of their neutron yield and ambient dose equivalent. Therefore, a clinical implementation of VHEEs would likely not warrant additional radioprotection safeguards compared to conventional RT treatments. Nature Publishing Group UK 2021-10-12 /pmc/articles/PMC8511248/ /pubmed/34642417 http://dx.doi.org/10.1038/s41598-021-99645-7 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Masilela, Thongchai A. M.
Delorme, Rachel
Prezado, Yolanda
Dosimetry and radioprotection evaluations of very high energy electron beams
title Dosimetry and radioprotection evaluations of very high energy electron beams
title_full Dosimetry and radioprotection evaluations of very high energy electron beams
title_fullStr Dosimetry and radioprotection evaluations of very high energy electron beams
title_full_unstemmed Dosimetry and radioprotection evaluations of very high energy electron beams
title_short Dosimetry and radioprotection evaluations of very high energy electron beams
title_sort dosimetry and radioprotection evaluations of very high energy electron beams
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8511248/
https://www.ncbi.nlm.nih.gov/pubmed/34642417
http://dx.doi.org/10.1038/s41598-021-99645-7
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